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Tmem222 transmembrane protein 222 [ Mus musculus (house mouse) ]

Gene ID: 52174, updated on 21-Apr-2024

Summary

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Official Symbol
Tmem222provided by MGI
Official Full Name
transmembrane protein 222provided by MGI
Primary source
MGI:MGI:1098568
See related
Ensembl:ENSMUSG00000028857 AllianceGenome:MGI:1098568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Ertd196e; 5730406H10Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human TMEM222 (transmembrane protein 222). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 33.8), cortex adult (RPKM 33.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 66.25 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132993356..133005101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133266045..133277791, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene ficolin C pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene synaptotagmin-like 1 Neighboring gene STARR-seq mESC enhancer starr_11620 Neighboring gene STARR-seq mESC enhancer starr_11622 Neighboring gene STARR-positive B cell enhancer mm9_chr4:132865900-132866201 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer ABC_E7995 Neighboring gene STARR-seq mESC enhancer starr_11626 Neighboring gene STARR-seq mESC enhancer starr_11627 Neighboring gene STARR-positive B cell enhancer ABC_E1657 Neighboring gene microRNA 5122 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • DKFZp564D0478

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025667.3 → NP_079943.2  transmembrane protein 222

    See identical proteins and their annotated locations for NP_079943.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AI847863, AK079189, AK160188
    Consensus CDS
    CCDS51321.1
    UniProtKB/Swiss-Prot
    A2AE96, Q8BVA2, Q8CI41, Q9CYN3
    Related
    ENSMUSP00000101527.3, ENSMUST00000105907.9
    Conserved Domains (1) summary
    pfam05608
    Location:61 → 178
    DUF778; Protein of unknown function (DUF778)

RNA

  1. NR_110978.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI834770, AK079189, AK160188

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132993356..133005101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539036.3 → XP_006539099.1  transmembrane protein 222 isoform X1

    Conserved Domains (1) summary
    pfam05608
    Location:1 → 82
    DUF778; Protein of unknown function (DUF778)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVA2.1 GenPept UniProtKB/Swiss-Prot:Q8BVA2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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