Kcnk6 potassium inwardly-rectifying channel, subfamily K, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk6provided by MGI
Official Full Name: potassium inwardly-rectifying channel, subfamily K, member 6provided by MGI
Primary source: MGI:MGI:1891291
See related: Ensembl:ENSMUSG00000046410 AllianceGenome:MGI:1891291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Toss; Twik2; D7Ertd764e
Summary: Predicted to enable potassium ion leak channel activity. Acts upstream of or within negative regulation of systemic arterial blood pressure and regulation of resting membrane potential. Predicted to be integral component of plasma membrane. Is expressed in heart; liver left lobe; and liver right lobe. Orthologous to human KCNK6 (potassium two pore domain channel subfamily K member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 24.4), stomach adult (RPKM 11.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.94 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28921353..28931947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (29221928..29232522, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endosomal trafficking of two-pore K[+] efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury.
Title: Endosomal trafficking of two-pore K(+) efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury.
Twik-2-/- mice have enhanced vasocontractility in the distal pulmonary vasculature.
Title: Twik-2(-/-) mouse demonstrates pulmonary vascular heterogeneity in intracellular pathways for vasocontractility.
Deletion of Kcnk6 (encoding two-pore domain K(+) channel TWIK2) prevents NLR Family, Pyrin Domain-Containing 3 Protein (NLRP3) inflammasome activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6(-/-) macrophages into mouse airways after macrophage depletion also prevents inflammatory lung injury.
Title: The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation.
mice deficient in the TWIK-2 channel develop pulmonary hypertension between 8 and 20 weeks of age through a mechanism involving Rho-kinase.
Title: TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235636

NoName (e-PCR)
- UniSTS:235637

NoName (e-PCR)
- UniSTS:235638

RH136303 (e-PCR)
- UniSTS:210295

D7Ertd764e (e-PCR), detects polymorphism
- UniSTS:167546

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of resting membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stabilization of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium channel subfamily K member 6

Names: TWIK-2 two-pore-domain K+ channel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.