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Mfhas1 malignant fibrous histiocytoma amplified sequence 1 [ Mus musculus (house mouse) ]

Gene ID: 52065, updated on 5-Mar-2024

Summary

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Official Symbol
Mfhas1provided by MGI
Official Full Name
malignant fibrous histiocytoma amplified sequence 1provided by MGI
Primary source
MGI:MGI:1098644
See related
Ensembl:ENSMUSG00000070056 AllianceGenome:MGI:1098644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd91e; 2310066G09Rik
Summary
Predicted to enable GTP binding activity; protein phosphatase 2A binding activity; and ubiquitin protein ligase binding activity. Involved in inflammatory response; innate immune response; and regulation of toll-like receptor 2 signaling pathway. Predicted to be located in cytoplasm. Is expressed in central nervous system; dorsal root ganglion; neural retina; and vibrissa. Orthologous to human MFHAS1 (multifunctional ROCO family signaling regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 12.2), lung adult (RPKM 10.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 21.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (36054922..36146603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (35587789..35679449)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9725 Neighboring gene predicted gene, 51568 Neighboring gene predicted gene, 39162 Neighboring gene STARR-seq mESC enhancer starr_21187 Neighboring gene predicted gene, 16793 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36741921-36742122 Neighboring gene RIKEN cDNA 1700015I17 gene Neighboring gene STARR-positive B cell enhancer ABC_E3773 Neighboring gene predicted gene, 35021 Neighboring gene predicted gene, 40492

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway. Chen W, et al. Oncotarget, 2016 Nov 29. PMID 27783989, Free PMC Article
  2. MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-κB Signaling Pathway Following Negative Regulation. Zhong J, et al. PLoS One, 2015. PMID 26599367, Free PMC Article
  3. Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Ng AC, et al. Proc Natl Acad Sci U S A, 2011 Mar 15. PMID 20616063, Free PMC Article
  4. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Colorectal carcinoma cells induce M2 polarization of tumor-associated macrophagess through MFHAS1 induction and subsequent STAT6 and KLF4 activation to promote CRC progression.
    Title: MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malignant fibrous histiocytoma-amplified sequence 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081279.2 → NP_001074748.1  malignant fibrous histiocytoma-amplified sequence 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001074748.1

    Status: VALIDATED

    Source sequence(s)
    AC129082, AC129211
    Consensus CDS
    CCDS40319.1
    UniProtKB/Swiss-Prot
    Q3TAN2, Q3V1N1, Q8C4N5
    Related
    ENSMUSP00000044135.6, ENSMUST00000037666.6
    Conserved Domains (5) summary
    cd00116
    Location:107 → 350
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:109 → 132
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:247 → 304
    LRR_8; Leucine rich repeat
    pfam16095
    Location:656 → 902
    COR; C-terminal of Roc, COR, domain
    cl21455
    Location:405 → 561
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001364259.1 → NP_001351188.1  malignant fibrous histiocytoma-amplified sequence 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129082, AC129211
    Conserved Domains (4) summary
    COG4886
    Location:42 → 338
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:109 → 132
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:656 → 902
    COR; C-terminal of Roc, COR, domain
    cl21455
    Location:405 → 561
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_157105.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129082, AC129211

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    36054922..36146603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934862.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V1N1.2 GenPept UniProtKB/Swiss-Prot:Q3V1N1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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