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Ppp1r10 protein phosphatase 1, regulatory subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 52040, updated on 3-Apr-2024

Summary

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Official Symbol
Ppp1r10provided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 10provided by MGI
Primary source
MGI:MGI:1289273
See related
Ensembl:ENSMUSG00000039220 AllianceGenome:MGI:1289273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fb19; Cat53; Pnuts; D17Ertd808e; 2610025H06Rik
Summary
Predicted to enable protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in chromatin. Part of PTW/PP1 phosphatase complex. Is expressed in central nervous system; early conceptus; oocyte; and retina. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.6), thymus adult (RPKM 16.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.77 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36227404..36243175)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35916512..35932283)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene STARR-seq mESC enhancer starr_42481 Neighboring gene microRNA 1894 Neighboring gene STARR-seq mESC enhancer starr_42482 Neighboring gene STARR-positive B cell enhancer ABC_E11644 Neighboring gene STARR-seq mESC enhancer starr_42484 Neighboring gene ring-box 1, pseudogene Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. De Leon G, et al. Int J Oncol, 2010 May. PMID 20372802, Free PMC Article
  2. PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Rose M, et al. Mol Cell Neurosci, 2008 Apr. PMID 18325784
  3. TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Kim H, et al. Nat Struct Mol Biol, 2009 Apr. PMID 19287395
  4. Identification and characterization of a novel human PP1 phosphatase complex. Lee JH, et al. J Biol Chem, 2010 Aug 6. PMID 20516061, Free PMC Article
  5. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 1 regulatory subunit 10
Names
HLA-C adjacent transcript 53
MHC class I region proline-rich protein CAT53
protein phosphatase I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163818.1 → NP_001157290.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

    See identical proteins and their annotated locations for NP_001157290.1

    Status: VALIDATED

    Source sequence(s)
    AW456628, BC052059
    Consensus CDS
    CCDS50098.1
    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
    UniProtKB/TrEMBL
    Q3ULI5
    Related
    ENSMUSP00000084460.7, ENSMUST00000087210.7
    Conserved Domains (2) summary
    pfam18044
    Location:858 → 880
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. NM_001357740.1 → NP_001344669.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

    Status: VALIDATED

    Source sequence(s)
    AJ504718, CR974451
    Consensus CDS
    CCDS50098.1
    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
    UniProtKB/TrEMBL
    Q3ULI5
    Conserved Domains (2) summary
    pfam18044
    Location:858 → 880
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  3. NM_001403564.1 → NP_001390493.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

    Status: VALIDATED

    Source sequence(s)
    CR974451
    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36227404..36243175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160685.1 → XP_036016578.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
    UniProtKB/TrEMBL
    Q3ULI5
    Conserved Domains (2) summary
    pfam18044
    Location:858 → 880
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. XM_006524617.2 → XP_006524680.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    See identical proteins and their annotated locations for XP_006524680.1

    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
    UniProtKB/TrEMBL
    Q3ULI5
    Related
    ENSMUSP00000084461.3, ENSMUST00000087211.9
    Conserved Domains (2) summary
    pfam18044
    Location:858 → 880
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  3. XM_006524619.3 → XP_006524682.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    See identical proteins and their annotated locations for XP_006524682.1

    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
    UniProtKB/TrEMBL
    Q3ULI5
    Conserved Domains (2) summary
    pfam18044
    Location:858 → 880
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  4. XM_030249898.2 → XP_030105758.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8
    UniProtKB/TrEMBL
    Q3ULI5
    Conserved Domains (2) summary
    pfam18044
    Location:858 → 880
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175934.3: Suppressed sequence

    Description
    NM_175934.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W00.1 GenPept UniProtKB/Swiss-Prot:Q80W00

Gene LinkOut

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