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Pibf1 progesterone immunomodulatory binding factor 1 [ Mus musculus (house mouse) ]

Gene ID: 52023, updated on 10-Mar-2024

Summary

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Official Symbol
Pibf1provided by MGI
Official Full Name
progesterone immunomodulatory binding factor 1provided by MGI
Primary source
MGI:MGI:1261910
See related
Ensembl:ENSMUSG00000022064 AllianceGenome:MGI:1261910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable interleukin-4 receptor binding activity. Predicted to be involved in several processes, including mitotic nuclear division; regulation of cytokine production; and regulation of protein phosphorylation. Predicted to be located in centrosome; extracellular space; and nucleus. Predicted to be active in centriolar satellite. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in Joubert syndrome 33. Orthologous to human PIBF1 (progesterone immunomodulatory binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.5), ovary adult (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 E2.2; 14 49.27 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99336892..99492335)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99099424..99254899)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene STARR-seq mESC enhancer starr_37436 Neighboring gene Kruppel-like transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_37437 Neighboring gene predicted gene, 22984

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells. Pallinger E, et al. Sci Rep, 2018 Mar 16. PMID 29549351, Free PMC Article
  2. Knockout mice created by TALEN-mediated gene targeting. Sung YH, et al. Nat Biotechnol, 2013 Jan. PMID 23302927
  3. Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Huang B, et al. Nat Med, 2017 Jan. PMID 27918564, Free PMC Article
  4. Tissue gene expression analysis using arrayed normalized cDNA libraries. Eickhoff H, et al. Genome Res, 2000 Aug. PMID 10958641, Free PMC Article
  5. A ciliopathy complex builds distal appendages to initiate ciliogenesis. Kumar D, et al. J Cell Biol, 2021 Sep 6. PMID 34241634, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
    Title: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
  2. Data suggest, that PIBF transported by the extracellular vesicles( EVs) from the embryo to maternal lymphocytes might induce increased IL-10 production by the latter, this way contributing to the Th2 dominant immune responses described during pregnancy.
    Title: PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells.
  3. B cell deficiency in mice resulted in a lower uterine level of active progesterone-induced blocking factor 1 (PIBF1), and susceptibility to preterm labor after inflammation. B cells are a significant producer of PIBF1 in mouse uterus in late gestation.
    Title: Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • 1700017E21Rik, 4930513H15Rik, 4933438D16Rik, 4933439E17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
progesterone-induced-blocking factor 1
Names
progesterone-induced blocking factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029320.4 → NP_083596.2  progesterone-induced-blocking factor 1

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154
    Consensus CDS
    CCDS36997.1
    UniProtKB/TrEMBL
    E9Q6K3
    Related
    ENSMUSP00000022650.8, ENSMUST00000022650.9
    Conserved Domains (1) summary
    pfam01496
    Location:475 → 558
    V_ATPase_I; V-type ATPase 116kDa subunit family

RNA

  1. NR_188872.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154

  2. NR_188873.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154

  3. NR_188874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AC165154

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    99336892..99492335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519256.5 → XP_006519319.1  progesterone-induced-blocking factor 1 isoform X5

    UniProtKB/TrEMBL
    Q8BIR5
    Conserved Domains (1) summary
    TIGR02168
    Location:125 → 406
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006519253.5 → XP_006519316.1  progesterone-induced-blocking factor 1 isoform X3

    Conserved Domains (2) summary
    TIGR02168
    Location:234 → 572
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:44 → 355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_036158751.1 → XP_036014644.1  progesterone-induced-blocking factor 1 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:21 → 684
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:234 → 538
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_003950865.2 RNA Sequence

  2. XR_383193.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029454.4: Suppressed sequence

    Description
    NM_029454.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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