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Kctd18 potassium channel tetramerisation domain containing 18 [ Mus musculus (house mouse) ]

Gene ID: 51960, updated on 23-Mar-2024

Summary

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Official Symbol
Kctd18provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 18provided by MGI
Primary source
MGI:MGI:3603813
See related
Ensembl:ENSMUSG00000054770 AllianceGenome:MGI:3603813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932411A20Rik; 6530404F10Rik
Summary
Is expressed in central nervous system and retina. Orthologous to human KCTD18 (potassium channel tetramerization domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3; 1 28.86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57994260..58009298, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57955101..57970141, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00995 Neighboring gene STARR-seq mESC enhancer starr_00996 Neighboring gene predicted gene, 57573 Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:57896765-57896993 Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159864.2 → NP_001153336.2  BTB/POZ domain-containing protein KCTD18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110735
    Consensus CDS
    CCDS48269.1
    Related
    ENSMUSP00000110052.4, ENSMUST00000114410.10

  2. NM_001159865.2 → NP_001153337.2  BTB/POZ domain-containing protein KCTD18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110735
    Consensus CDS
    CCDS48268.1
    Related
    ENSMUSP00000130952.2, ENSMUST00000164963.8

  3. NM_001428727.1 → NP_001415656.1  BTB/POZ domain-containing protein KCTD18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110735

  4. NM_001428728.1 → NP_001415657.1  BTB/POZ domain-containing protein KCTD18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110735

  5. NM_001428729.1 → NP_001415658.1  BTB/POZ domain-containing protein KCTD18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110735

  6. NM_001428730.1 → NP_001415659.1  BTB/POZ domain-containing protein KCTD18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110735

  7. NM_001428731.1 → NP_001415660.1  BTB/POZ domain-containing protein KCTD18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110735

  8. NM_001428732.1 → NP_001415661.1  BTB/POZ domain-containing protein KCTD18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110735

  9. NM_001428733.1 → NP_001415662.1  BTB/POZ domain-containing protein KCTD18 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110735

  10. NM_001428734.1 → NP_001415663.1  BTB/POZ domain-containing protein KCTD18 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110735

  11. NM_001428735.1 → NP_001415664.1  BTB/POZ domain-containing protein KCTD18 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110735

RNA

  1. NR_027630.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110735
    Related
    ENSMUST00000161608.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    57994260..58009298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496136.5 → XP_006496199.1  BTB/POZ domain-containing protein KCTD18 isoform X1

    Conserved Domains (2) summary
    cd18372
    Location:23 → 123
    BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
    pfam17669
    Location:339 → 414
    DUF5529; Family of unknown function (DUF5529)

  2. XM_036152324.1 → XP_036008217.1  BTB/POZ domain-containing protein KCTD18 isoform X3

    Conserved Domains (1) summary
    cl38908
    Location:23 → 107
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  3. XM_006496135.4 → XP_006496198.1  BTB/POZ domain-containing protein KCTD18 isoform X1

    Conserved Domains (2) summary
    cd18372
    Location:23 → 123
    BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
    pfam17669
    Location:339 → 414
    DUF5529; Family of unknown function (DUF5529)

  4. XM_017321677.3 → XP_017177166.1  BTB/POZ domain-containing protein KCTD18 isoform X4

  5. XM_017321676.3 → XP_017177165.1  BTB/POZ domain-containing protein KCTD18 isoform X2

    Conserved Domains (1) summary
    pfam17669
    Location:218 → 293
    DUF5529; Family of unknown function (DUF5529)

  6. XM_036152329.1 → XP_036008222.1  BTB/POZ domain-containing protein KCTD18 isoform X4

    Conserved Domains (1) summary
    pfam15323
    Location:66 → 174
    Ashwin; Developmental protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030211.3: Suppressed sequence

    Description
    NM_030211.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
Nucleotide Protein Strain
Heading Accession and Version

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