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Knstrn kinetochore-localized astrin/SPAG5 binding [ Mus musculus (house mouse) ]

Gene ID: 51944, updated on 5-Mar-2024

Summary

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Official Symbol
Knstrnprovided by MGI
Official Full Name
kinetochore-localized astrin/SPAG5 bindingprovided by MGI
Primary source
MGI:MGI:1289298
See related
Ensembl:ENSMUSG00000027331 AllianceGenome:MGI:1289298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SKAP; C15orf23; Traf4af1; D2Ertd750e; 1700025D04Rik
Summary
Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to act upstream of or within cell division. Predicted to be located in plasma membrane and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 18.2), CNS E11.5 (RPKM 17.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Knstrn in Genome Data Viewer
Location:
2 E5; 2 59.46 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118644470..118667691)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118813988..118837210)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 2 Neighboring gene predicted gene, 38629 Neighboring gene predicted gene, 39913 Neighboring gene STARR-positive B cell enhancer ABC_E2638 Neighboring gene isovaleryl coenzyme A dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E4491 Neighboring gene STARR-positive B cell enhancer ABC_E9528 Neighboring gene predicted gene, 32798

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of SKAP/kinastrin isoforms: the N-terminus defines tissue specificity and Pontin binding. Cindric Vranesic A, et al. Hum Mol Genet, 2016 Jul 1. PMID 27170314
  2. SKAP, an outer kinetochore protein, is required for mouse germ cell development. Grey C, et al. Reproduction, 2016 Mar. PMID 26667018, Free PMC Article
  3. DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. Lau EO, et al. Elife, 2021 Apr 26. PMID 33899739, Free PMC Article
  4. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. important role in the successful outcome of male gametogenesis
    Title: SKAP, an outer kinetochore protein, is required for mouse germ cell development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small kinetochore-associated protein
Names
TRAF4 associated factor 1 homolog
TRAF4-associated factor 1
kinastrin
kinetochore-localized astrin-binding protein
kinetochore-localized astrin/SPAG5-binding protein
putative TRAF4-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026412.3 → NP_080688.2  small kinetochore-associated protein

    See identical proteins and their annotated locations for NP_080688.2

    Status: VALIDATED

    Source sequence(s)
    AK006328, AK028590, AK036374
    Consensus CDS
    CCDS16585.1
    UniProtKB/Swiss-Prot
    Q8K2D9, Q9D9Z1
    Related
    ENSMUSP00000115860.2, ENSMUST00000134661.8
    Conserved Domains (1) summary
    PRK12704
    Location:144 → 308
    PRK12704; phosphodiesterase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118644470..118667691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319123.2 → XP_017174612.1  small kinetochore-associated protein isoform X1

    Conserved Domains (1) summary
    pfam12128
    Location:127 → 272
    DUF3584; Protein of unknown function (DUF3584)

RNA

  1. XR_374488.4 RNA Sequence

  2. XR_374487.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9Z1.2 GenPept UniProtKB/Swiss-Prot:Q9D9Z1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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