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Rundc3a RUN domain containing 3A [ Mus musculus (house mouse) ]

Gene ID: 51799, updated on 5-Mar-2024

Summary

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Official Symbol
Rundc3aprovided by MGI
Official Full Name
RUN domain containing 3Aprovided by MGI
Primary source
MGI:MGI:1858752
See related
Ensembl:ENSMUSG00000006575 AllianceGenome:MGI:1858752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpip8; RPIP-8; Rap2ip
Summary
Predicted to be involved in positive regulation of cGMP-mediated signaling. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; gut; nervous system; nose; and retina. Orthologous to human RUNDC3A (RUN domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 61.8), frontal lobe adult (RPKM 60.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 66.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102284219..102293381)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102393394..102402555)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 (anion exchanger), member 1 Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene STARR-positive B cell enhancer ABC_E11495 Neighboring gene solute carrier family 25, member 39 Neighboring gene STARR-positive B cell enhancer ABC_E5282 Neighboring gene microRNA 6930 Neighboring gene STARR-seq mESC enhancer starr_30808 Neighboring gene STARR-positive B cell enhancers ABC_E9375 and ABC_E8457 Neighboring gene granulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a specific effector of the small GTP-binding protein Rap2. Janoueix-Lerosey I, et al. Eur J Biochem, 1998 Mar 1. PMID 9523700
  2. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. Myagmar BE, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752761
  3. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  4. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that PARG1 is a putative specific effector of Rap2 to regulate Rho.
    Title: PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RUN domain-containing protein 3A
Names
Rap2 interacting protein 8
rap2-interacting protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252347.2 → NP_001239276.1  RUN domain-containing protein 3A isoform 2

    See identical proteins and their annotated locations for NP_001239276.1

    Status: VALIDATED

    Source sequence(s)
    AL596258, BC046319, BY277835
    Consensus CDS
    CCDS56812.1
    UniProtKB/Swiss-Prot
    O08576
    Related
    ENSMUSP00000102722.3, ENSMUST00000107105.9
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 188
    RUN; RUN domain
    cl09111
    Location:255 → 315
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  2. NM_001362803.1 → NP_001349732.1  RUN domain-containing protein 3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596258
    Conserved Domains (1) summary
    pfam02759
    Location:60 → 182
    RUN; RUN domain

  3. NM_001362804.1 → NP_001349733.1  RUN domain-containing protein 3A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596258
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam11180
    Location:263 → 321
    DUF2968; Protein of unknown function (DUF2968)

  4. NM_016759.5 → NP_058039.1  RUN domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_058039.1

    Status: VALIDATED

    Source sequence(s)
    AK002856, AL596258, BC046319, BY277835
    Consensus CDS
    CCDS25497.1
    UniProtKB/Swiss-Prot
    A2A693, A2A694, O08576, Q80Y95
    Related
    ENSMUSP00000006750.8, ENSMUST00000006750.8
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 188
    RUN; RUN domain
    pfam15898
    Location:267 → 321
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102284219..102293381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533690.2 → XP_006533753.1  RUN domain-containing protein 3A isoform X3

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:255 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

  2. XM_006533693.4 → XP_006533756.1  RUN domain-containing protein 3A isoform X10

    UniProtKB/Swiss-Prot
    O08576
    Related
    ENSMUSP00000102719.2, ENSMUST00000107102.8
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 186
    RUN; RUN domain
    pfam06785
    Location:255 → 318
    UPF0242; Uncharacterized protein family (UPF0242)

  3. XM_030246121.2 → XP_030101981.1  RUN domain-containing protein 3A isoform X7

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 181
    RUN; RUN domain
    pfam06785
    Location:250 → 313
    UPF0242; Uncharacterized protein family (UPF0242)

  4. XM_006533688.2 → XP_006533751.1  RUN domain-containing protein 3A isoform X1

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 197
    RUN; RUN domain
    pfam06785
    Location:266 → 329
    UPF0242; Uncharacterized protein family (UPF0242)

  5. XM_017314648.3 → XP_017170137.1  RUN domain-containing protein 3A isoform X9

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 197
    RUN; RUN domain
    pfam06785
    Location:266 → 329
    UPF0242; Uncharacterized protein family (UPF0242)

  6. XM_006533689.3 → XP_006533752.1  RUN domain-containing protein 3A isoform X2

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 197
    RUN; RUN domain
    pfam06785
    Location:266 → 329
    UPF0242; Uncharacterized protein family (UPF0242)

  7. XM_006533691.2 → XP_006533754.1  RUN domain-containing protein 3A isoform X4

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 182
    RUN; RUN domain
    pfam06785
    Location:251 → 314
    UPF0242; Uncharacterized protein family (UPF0242)

  8. XM_017314647.3 → XP_017170136.1  RUN domain-containing protein 3A isoform X6

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 182
    RUN; RUN domain
    pfam06785
    Location:251 → 314
    UPF0242; Uncharacterized protein family (UPF0242)

  9. XM_006533692.2 → XP_006533755.1  RUN domain-containing protein 3A isoform X5

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 181
    RUN; RUN domain
    pfam06785
    Location:250 → 313
    UPF0242; Uncharacterized protein family (UPF0242)

  10. XM_006533694.4 → XP_006533757.1  RUN domain-containing protein 3A isoform X11

    UniProtKB/Swiss-Prot
    O08576
    Related
    ENSMUSP00000102720.2, ENSMUST00000107103.8
    Conserved Domains (2) summary
    pfam02759
    Location:60 → 181
    RUN; RUN domain
    pfam06785
    Location:250 → 313
    UPF0242; Uncharacterized protein family (UPF0242)

  11. XM_011249124.2 → XP_011247426.1  RUN domain-containing protein 3A isoform X8

    Conserved Domains (2) summary
    pfam02759
    Location:60 → 197
    RUN; RUN domain
    pfam06785
    Location:266 → 329
    UPF0242; Uncharacterized protein family (UPF0242)

RNA

  1. XR_003949474.2 RNA Sequence

  2. XR_003949475.2 RNA Sequence

  3. XR_001780024.2 RNA Sequence

  4. XR_003949473.2 RNA Sequence

  5. XR_004936988.1 RNA Sequence

  6. XR_003949476.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08576.1 GenPept UniProtKB/Swiss-Prot:O08576

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