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Cpsf2 cleavage and polyadenylation specific factor 2 [ Mus musculus (house mouse) ]

Gene ID: 51786, updated on 11-Apr-2024

Summary

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Official Symbol
Cpsf2provided by MGI
Official Full Name
cleavage and polyadenylation specific factor 2provided by MGI
Primary source
MGI:MGI:1861601
See related
Ensembl:ENSMUSG00000041781 AllianceGenome:MGI:1861601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpsf; MCPSF; 100kDa; mKIAA1367; 2610024B04Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; mRNA polyadenylation; and pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA processing. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.5), liver E14 (RPKM 8.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 51.34 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101940345..101972252)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101975759..102005993)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene predicted gene, 20036 Neighboring gene STARR-positive B cell enhancer ABC_E1452 Neighboring gene ataxin 3 Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Rift Valley Fever virus protein NSm and putative cellular protein interactions. Engdahl C, et al. Virol J, 2012 Jul 28. PMID 22838834, Free PMC Article
  2. N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. Huang YS, et al. EMBO J, 2002 May 1. PMID 11980711, Free PMC Article
  3. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
  4. Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. Collart C, et al. Genes Cells, 2005 Sep. PMID 16115198
  5. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Udagawa T, et al. Mol Cell, 2012 Jul 27. PMID 22727665, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cpsf2,Ppil2, and SNAP-25 are the most promising targets for the NSm protein of the virus during an infection.
    Title: The Rift Valley Fever virus protein NSm and putative cellular protein interactions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in glutamatergic synapse IC
Inferred by Curator
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
cleavage and polyadenylation specificity factor subunit 2
Names
CPSF 100 kDa subunit
cleavage and polyadenylation specific factor 2, 100kD subunit
cleavage and polyadenylation specificity factor 100 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016856.3 → NP_058552.1  cleavage and polyadenylation specificity factor subunit 2

    See identical proteins and their annotated locations for NP_058552.1

    Status: VALIDATED

    Source sequence(s)
    AF012822, AK078904, AK084961, AK147746, BE951303
    Consensus CDS
    CCDS26116.1
    UniProtKB/Swiss-Prot
    O35218
    Related
    ENSMUSP00000047797.9, ENSMUST00000047357.10
    Conserved Domains (4) summary
    smart01027
    Location:243 → 368
    Beta-Casp; Beta-Casp domain
    cd16293
    Location:7 → 204
    CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
    pfam13299
    Location:608 → 779
    CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
    pfam07521
    Location:528 → 591
    RMMBL; Zn-dependent metallo-hydrolase RNA specificity domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    101940345..101972252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516071.5 → XP_006516134.1  cleavage and polyadenylation specificity factor subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006516134.1

    UniProtKB/Swiss-Prot
    O35218
    Conserved Domains (4) summary
    smart01027
    Location:243 → 368
    Beta-Casp; Beta-Casp domain
    cd16293
    Location:7 → 204
    CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
    pfam13299
    Location:608 → 779
    CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
    pfam07521
    Location:528 → 591
    RMMBL; Zn-dependent metallo-hydrolase RNA specificity domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35218.1 GenPept UniProtKB/Swiss-Prot:O35218

Gene LinkOut

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