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HDAC7 histone deacetylase 7 [ Homo sapiens (human) ]

Gene ID: 51564, updated on 3-Apr-2024

Summary

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Official Symbol
HDAC7provided by HGNC
Official Full Name
histone deacetylase 7provided by HGNC
Primary source
HGNC:HGNC:14067
See related
Ensembl:ENSG00000061273 MIM:606542; AllianceGenome:HGNC:14067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HD7; HD7A; HDAC7A
Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 18.9), spleen (RPKM 18.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q13.11
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (47782722..47821344, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (47744115..47782739, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48176505..48213686, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RPAP3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4395 Neighboring gene endonuclease, poly(U) specific Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:48131928-48133127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6261 Neighboring gene Rap guanine nucleotide exchange factor 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48146243-48146784 Neighboring gene Sharpr-MPRA regulatory region 8178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48151874-48152542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48152543-48153211 Neighboring gene solute carrier family 48 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48167242-48167748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48167749-48168253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4399 Neighboring gene uncharacterized LOC124902926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48211237-48211897 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48212615-48213188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4403 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48214527-48215448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6269 Neighboring gene long intergenic non-protein coding RNA 2354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48236992-48237565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48237566-48238138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48239663-48240164 Neighboring gene vitamin D receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48262276-48262776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48276324-48276836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4404

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease. Wang Y, et al. FEBS J, 2023 Jun. PMID 35303381, Free PMC Article
  2. A regulative epigenetic circuit supervised by HDAC7 represses IGFBP6 and IGFBP7 expression to sustain mammary stemness. Giorgio ED, et al. Epigenomics, 2021 May. PMID 33878891
  3. Histone Deacetylase 7 Gene Overexpression Is Associated with Poor Prognosis of Triple-Negative Breast Cancer Patients. Uzelac B, et al. Genet Test Mol Biomarkers, 2021 Mar. PMID 33734898
  4. HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia. de Barrios O, et al. Leukemia, 2021 Jul. PMID 33262526
  5. HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients. Burgess M, et al. Oncogene, 2020 Aug. PMID 32709923

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comprehensive analysis of HDAC7 expression and its prognostic value in diffuse large B cell lymphoma: A review.
    Title: Comprehensive analysis of HDAC7 expression and its prognostic value in diffuse large B cell lymphoma: A review.
  2. Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
    Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
  3. Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease.
    Title: Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease.
  4. Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/beta-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.
    Title: Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.
  5. WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
    Title: WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
  6. A regulative epigenetic circuit supervised by HDAC7 represses IGFBP6 and IGFBP7 expression to sustain mammary stemness.
    Title: A regulative epigenetic circuit supervised by HDAC7 represses IGFBP6 and IGFBP7 expression to sustain mammary stemness.
  7. Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation.
    Title: Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation.
  8. Histone Deacetylase 7 Gene Overexpression Is Associated with Poor Prognosis of Triple-Negative Breast Cancer Patients.
    Title: Histone Deacetylase 7 Gene Overexpression Is Associated with Poor Prognosis of Triple-Negative Breast Cancer Patients.
  9. HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.
    Title: HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.
  10. Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
    Title: Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA downregulates HDAC7 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ99588, DKFZp586J0917

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SUMO transferase activity TAS
Traceable Author Statement
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell junction assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deacetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in regulation of mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 7
Names
histone deacetylase 7A
NP_001091886.1
NP_001295019.1
NP_001354975.1
NP_056216.2
XP_011536782.1
XP_011536783.2
XP_011536785.1
XP_024304786.1
XP_047284934.1
XP_047284935.1
XP_047284936.1
XP_047284937.1
XP_047284938.1
XP_047284939.1
XP_047284940.1
XP_054228219.1
XP_054228220.1
XP_054228221.1
XP_054228222.1
XP_054228223.1
XP_054228224.1
XP_054228225.1
XP_054228226.1
XP_054228227.1
XP_054228228.1
XP_054228229.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098416.4 → NP_001091886.1  histone deacetylase 7 isoform d

    See identical proteins and their annotated locations for NP_001091886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter than isoform a.
    Source sequence(s)
    BC020505, BC064840, DC376749
    Consensus CDS
    CCDS41776.1
    UniProtKB/TrEMBL
    J3KPH8
    Related
    ENSP00000351326.3, ENST00000354334.7
    Conserved Domains (1) summary
    cd10008
    Location:520 → 897
    HDAC7; Histone deacetylase 7

  2. NM_001308090.2 → NP_001295019.1  histone deacetylase 7 isoform e

    See identical proteins and their annotated locations for NP_001295019.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter than isoform a.
    Source sequence(s)
    AK122588, AK299292, AK303481, BM144303, DC376749
    Consensus CDS
    CCDS81685.1
    UniProtKB/TrEMBL
    J3KPH8
    Related
    ENSP00000448532.1, ENST00000552960.5
    Conserved Domains (1) summary
    cd10008
    Location:540 → 917
    HDAC7; Histone deacetylase 7

  3. NM_001368046.1 → NP_001354975.1  histone deacetylase 7 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (f).
    Source sequence(s)
    AC004466
    UniProtKB/TrEMBL
    J3KPH8

  4. NM_015401.5 → NP_056216.2  histone deacetylase 7 isoform a

    See identical proteins and their annotated locations for NP_056216.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as variant 3) encodes isoform a (also known as isoform c).
    Source sequence(s)
    AY302468, BC020505, DC376749
    Consensus CDS
    CCDS8756.2
    UniProtKB/TrEMBL
    J3KPH8
    Related
    ENSP00000080059.7, ENST00000080059.12
    Conserved Domains (1) summary
    cd10008
    Location:557 → 934
    HDAC7; Histone deacetylase 7

RNA

  1. NR_160435.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004466
    Related
    ENST00000470668.5

  2. NR_160436.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004466

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    47782722..47821344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428980.1 → XP_047284936.1  histone deacetylase 7 isoform X6

  2. XM_047428979.1 → XP_047284935.1  histone deacetylase 7 isoform X5

  3. XM_011538481.2 → XP_011536783.2  histone deacetylase 7 isoform X1

  4. XM_047428983.1 → XP_047284939.1  histone deacetylase 7 isoform X9

  5. XM_047428978.1 → XP_047284934.1  histone deacetylase 7 isoform X2

  6. XM_024449018.2 → XP_024304786.1  histone deacetylase 7 isoform X3

    UniProtKB/TrEMBL
    J3KPH8
    Conserved Domains (1) summary
    cd10008
    Location:564 → 941
    HDAC7; Histone deacetylase 7

  7. XM_047428981.1 → XP_047284937.1  histone deacetylase 7 isoform X7

  8. XM_011538480.1 → XP_011536782.1  histone deacetylase 7 isoform X4

    UniProtKB/TrEMBL
    J3KPH8
    Conserved Domains (1) summary
    cd10008
    Location:564 → 941
    HDAC7; Histone deacetylase 7

  9. XM_047428982.1 → XP_047284938.1  histone deacetylase 7 isoform X8

    UniProtKB/Swiss-Prot
    B3KY08, B4DWI0, B4E0Q5, Q6P1W9, Q6W9G7, Q7Z4K2, Q7Z5I1, Q8WUI4, Q96K01, Q9BR73, Q9H7L0, Q9NW41, Q9NWA9, Q9NYK9, Q9UFU7
    Related
    ENSP00000404394.2, ENST00000427332.6

  10. XM_047428984.1 → XP_047284940.1  histone deacetylase 7 isoform X8

    UniProtKB/Swiss-Prot
    B3KY08, B4DWI0, B4E0Q5, Q6P1W9, Q6W9G7, Q7Z4K2, Q7Z5I1, Q8WUI4, Q96K01, Q9BR73, Q9H7L0, Q9NW41, Q9NWA9, Q9NYK9, Q9UFU7

  11. XM_011538483.1 → XP_011536785.1  histone deacetylase 7 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    47744115..47782739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372249.1 → XP_054228224.1  histone deacetylase 7 isoform X6

  2. XM_054372248.1 → XP_054228223.1  histone deacetylase 7 isoform X5

  3. XM_054372244.1 → XP_054228219.1  histone deacetylase 7 isoform X1

  4. XM_054372252.1 → XP_054228227.1  histone deacetylase 7 isoform X9

  5. XM_054372245.1 → XP_054228220.1  histone deacetylase 7 isoform X2

  6. XM_054372246.1 → XP_054228221.1  histone deacetylase 7 isoform X3

  7. XM_054372250.1 → XP_054228225.1  histone deacetylase 7 isoform X7

  8. XM_054372247.1 → XP_054228222.1  histone deacetylase 7 isoform X4

  9. XM_054372251.1 → XP_054228226.1  histone deacetylase 7 isoform X8

    UniProtKB/Swiss-Prot
    B3KY08, B4DWI0, B4E0Q5, Q6P1W9, Q6W9G7, Q7Z4K2, Q7Z5I1, Q8WUI4, Q96K01, Q9BR73, Q9H7L0, Q9NW41, Q9NWA9, Q9NYK9, Q9UFU7

  10. XM_054372253.1 → XP_054228228.1  histone deacetylase 7 isoform X8

    UniProtKB/Swiss-Prot
    B3KY08, B4DWI0, B4E0Q5, Q6P1W9, Q6W9G7, Q7Z4K2, Q7Z5I1, Q8WUI4, Q96K01, Q9BR73, Q9H7L0, Q9NW41, Q9NWA9, Q9NYK9, Q9UFU7

  11. XM_054372254.1 → XP_054228229.1  histone deacetylase 7 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016596.3: Suppressed sequence

    Description
    NM_016596.3: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUI4.2 GenPept UniProtKB/Swiss-Prot:Q8WUI4

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