SIRT7 sirtuin 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIRT7provided by HGNC
Official Full Name: sirtuin 7provided by HGNC
Primary source: HGNC:HGNC:14935
See related: Ensembl:ENSG00000187531 MIM:606212; AllianceGenome:HGNC:14935
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIR2L7
Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81911939..81918176, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82779099..82785336, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79869815..79876052, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.
Title: KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.
Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krupple-like factor 4 deacetylation.
Title: Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation.
SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23.
Title: SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23.
USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1.
Title: USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1.
SIRT7: the seventh key to unlocking the mystery of aging.
Title: SIRT7: the seventh key to unlocking the mystery of aging.
MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
Title: MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
Musclin attenuates lipid deposition in hepatocytes through SIRT7/autophagy-mediated suppression of ER stress.
Title: Musclin attenuates lipid deposition in hepatocytes through SIRT7/autophagy-mediated suppression of ER stress.
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Title: A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer.
Title: Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer.
SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation.
Title: SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH65676 (e-PCR)
- UniSTS:37993

SIRT7_1731 (e-PCR)
- UniSTS:277714

NoName (e-PCR)
- UniSTS:483294

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone H3K18 deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD-dependent histone H3K18 deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent histone H3K18 deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD-dependent protein deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-glutaryllysine deglutarylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutaryllysine deglutarylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-malonyllysine demalonylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-propionyllysine depropionylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-succinyllysine desuccinylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-succinyllysine desuccinylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in R-loop processing	IDA Inferred from Direct Assay more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous chromosome pairing at meiosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression, epigenetic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine demalonylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-lysine desuccinylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of rRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deglutarylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deglutarylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein depropionylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in retrotransposon silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus organizer region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-7

Names: NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; sir2-related protein type 7; sirtuin type 7

NP_057622.1

EC 2.3.1.286

XP_011521882.1

EC 2.3.1.286

XP_047292184.1

EC 2.3.1.286

XP_047292185.1

EC 2.3.1.286

XP_047292186.1

EC 2.3.1.286

XP_047292187.1

EC 2.3.1.286

XP_054172376.1

EC 2.3.1.286

XP_054172377.1

EC 2.3.1.286

XP_054172378.1

EC 2.3.1.286

XP_054172379.1

EC 2.3.1.286

XP_054172380.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016538.3 → NP_057622.1 NAD-dependent protein deacetylase sirtuin-7

See identical proteins and their annotated locations for NP_057622.1

Status: REVIEWED

Source sequence(s)

BC017305, BC101791, BQ890203, CD579273

Consensus CDS

CCDS11792.1

UniProtKB/Swiss-Prot

A8K2K0, B3KSU8, Q3MIK4, Q9NRC8, Q9NSZ6, Q9NUS6

Related

ENSP00000329466.6, ENST00000328666.11

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

81911939..81918176 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011523580.2 → XP_011521882.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1

See identical proteins and their annotated locations for XP_011521882.1

Conserved Domains (1) summary

cd01410
Location:78 → 279

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
XM_047436229.1 → XP_047292185.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3
XM_047436228.1 → XP_047292184.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2
XM_047436231.1 → XP_047292187.1 NAD-dependent protein deacetylase sirtuin-7 isoform X5
XM_047436230.1 → XP_047292186.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

82779099..82785336 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316401.1 → XP_054172376.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1
XM_054316403.1 → XP_054172378.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3
XM_054316402.1 → XP_054172377.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2
XM_054316405.1 → XP_054172380.1 NAD-dependent protein deacetylase sirtuin-7 isoform X5
XM_054316404.1 → XP_054172379.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4