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ANAPC11 anaphase promoting complex subunit 11 [ Homo sapiens (human) ]

Gene ID: 51529, updated on 5-Mar-2024

Summary

Official Symbol
ANAPC11provided by HGNC
Official Full Name
anaphase promoting complex subunit 11provided by HGNC
Primary source
HGNC:HGNC:14452
See related
Ensembl:ENSG00000141552 MIM:614534; AllianceGenome:HGNC:14452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC11; Apc11p; HSPC214
Summary
Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues See more
Orthologs
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Genomic context

See ANAPC11 in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81890790..81900533)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82757952..82767693)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79848666..79858409)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79813353-79813852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9154 Neighboring gene uncharacterized LOC124904086 Neighboring gene Sharpr-MPRA regulatory region 9355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79823980-79824608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79825239-79825867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79825868-79826497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79826498-79827126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12983 Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:79846281-79847480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9161 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79850899-79851114 Neighboring gene Aly/REF export factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9164 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9166 Neighboring gene neuropeptide B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene sirtuin 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NPB

Clone Names

  • MGC882

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 11
Names
APC11 anaphase promoting complex subunit 11 homolog
anaphase promoting complex subunit 11 (yeast APC11 homolog)
cyclosome subunit 11
hepatocellular carcinoma-associated RING finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002244.2NP_001002244.1  anaphase-promoting complex subunit 11 isoform 1

    See identical proteins and their annotated locations for NP_001002244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK308091, BC000607, HY067392
    Consensus CDS
    CCDS32769.1
    Related
    ENSP00000349957.3, ENST00000357385.7
    Conserved Domains (1) summary
    cl17238
    Location:151
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_001002245.2NP_001002245.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000461648.2, ENST00000571024.6
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. NM_001002246.2NP_001002246.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AF151048, AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000460064.2, ENST00000574924.6
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  4. NM_001002247.2NP_001002247.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000463640.1, ENST00000579978.5
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  5. NM_001002248.3NP_001002248.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AF151048, AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000339695.5, ENST00000344877.10
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  6. NM_001002249.2NP_001002249.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC066308, BM845909
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000376181.3, ENST00000392376.7
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  7. NM_001289414.1NP_001276343.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AA356010, AK308091, AW965775
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000458143.1, ENST00000571570.5
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  8. NM_001289415.1NP_001276344.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC171898, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000458265.2, ENST00000572851.6
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  9. NM_001289416.1NP_001276345.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC066308, BM845909, BY796995
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000463598.1, ENST00000583839.1
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  10. NM_001289417.1NP_001276346.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate splice site and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AC145207, AK308091, CA335305, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000464615.1, ENST00000578550.5
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  11. NM_001289420.1NP_001276349.1  anaphase-promoting complex subunit 11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks an exon and contains two alternate exons in the 5' UTR, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC145207, AK308091, BC066308, BM762129, BM845909
    UniProtKB/Swiss-Prot
    Q9NYG5
    Conserved Domains (2) summary
    pfam12678
    Location:237
    zf-rbx1; RING-H2 zinc finger
    cl17238
    Location:151
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  12. NM_016476.11NP_057560.8  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_057560.8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AF151048, AK308091, BC000607, BF512771, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
    Related
    ENSP00000459200.2, ENST00000571874.6
    Conserved Domains (1) summary
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81890790..81900533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82757952..82767693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001289418.1: Suppressed sequence

    Description
    NM_001289418.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_001289419.1: Suppressed sequence

    Description
    NM_001289419.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.