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JKAMP JNK1/MAPK8 associated membrane protein [ Homo sapiens (human) ]

Gene ID: 51528, updated on 3-Apr-2024

Summary

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Official Symbol
JKAMPprovided by HGNC
Official Full Name
JNK1/MAPK8 associated membrane proteinprovided by HGNC
Primary source
HGNC:HGNC:20184
See related
Ensembl:ENSG00000050130 MIM:611176; AllianceGenome:HGNC:20184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAMP; CDA06; HSPC213; HSPC327; C14orf100; C24orf100
Summary
Enables ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 16.2), adrenal (RPKM 14.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See JKAMP in Genome Data Viewer
Location:
14q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (59484517..59505410)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (53691449..53712359)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59951235..59972128)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5803 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59655908-59656667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8458 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34577 Neighboring gene Sharpr-MPRA regulatory region 14842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5805 Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8459 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59797736-59798544 Neighboring gene NANOG hESC enhancer GRCh37_chr14:59862330-59862839 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8461 Neighboring gene uncharacterized LOC124903326 Neighboring gene G protein-coupled receptor 135 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene coiled-coil domain containing 175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene leucine rich repeat containing 9 Neighboring gene PCNX4 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. JAMP optimizes ERAD to protect cells from unfolded proteins. Tcherpakov M, et al. Mol Biol Cell, 2008 Nov. PMID 18784250, Free PMC Article
  2. Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Cubero FJ, et al. J Hepatol, 2015 Jan. PMID 25173965
  3. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Kadoya T, et al. Mol Cell Biol, 2005 Oct. PMID 16166642, Free PMC Article
  4. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). Tcherpakov M, et al. J Biol Chem, 2009 May 1. PMID 19269966, Free PMC Article
  5. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. Behrends U, et al. Int J Cancer, 2003 Aug 20. PMID 12800201

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. synergistic function of Jnk1 in haematopoietic cells and hepatocytes might be relevant for the development of chronic liver injury
    Title: Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury.
  2. Expression of DP, a receptor largely retained in the ER, promoted proteasome recruitment by JAMP.
    Title: Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP.
    Title: Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).
  5. JAMP is an important component for coordinated clearance of misfolded proteins from the endoplasmic reticulum.
    Title: JAMP optimizes ERAD to protect cells from unfolded proteins.
  6. Identification and functional characterization of the mouse Jamp ortholog.
    Title: JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ46787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
JNK1/MAPK8-associated membrane protein
Names
JNK-associated membrane protein
Jun N-terminal kinase 1-associated membrane protein
medulloblastoma antigen MU-MB-50.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098625.3 → NP_001092095.1  JNK1/MAPK8-associated membrane protein isoform 2

    See identical proteins and their annotated locations for NP_001092095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL121694, BC005198, BX161501, HY340214
    Consensus CDS
    CCDS45117.1
    UniProtKB/TrEMBL
    B3KPC2
    Related
    ENSP00000389699.2, ENST00000425728.6
    Conserved Domains (1) summary
    pfam05571
    Location:3 → 294
    DUF766; Protein of unknown function (DUF766)

  2. NM_001284201.2 → NP_001271130.1  JNK1/MAPK8-associated membrane protein isoform 3

    See identical proteins and their annotated locations for NP_001271130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK056145, AL121694, BX161501, DC381037, HY340214
    Consensus CDS
    CCDS61462.1
    UniProtKB/TrEMBL
    B3KPC2, G3V2M4
    Related
    ENSP00000450749.1, ENST00000554271.5
    Conserved Domains (1) summary
    pfam05571
    Location:23 → 314
    DUF766; Protein of unknown function (DUF766)

  3. NM_001284202.2 → NP_001271131.1  JNK1/MAPK8-associated membrane protein isoform 4 precursor

    See identical proteins and their annotated locations for NP_001271131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL121694, BX161501, DC381037, HY340214
    Consensus CDS
    CCDS61463.1
    UniProtKB/TrEMBL
    B3KPC2
    Related
    ENSP00000348351.5, ENST00000356057.9
    Conserved Domains (1) summary
    pfam05571
    Location:17 → 308
    DUF766; Protein of unknown function (DUF766)

  4. NM_001284203.2 → NP_001271132.1  JNK1/MAPK8-associated membrane protein isoform 5

    See identical proteins and their annotated locations for NP_001271132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298209, AL121694, BX161501, DC381037, HY340214
    Related
    ENST00000602482.5
    Conserved Domains (1) summary
    pfam05571
    Location:1 → 237
    DUF766; Protein of unknown function (DUF766)

  5. NM_001284204.2 → NP_001271133.1  JNK1/MAPK8-associated membrane protein isoform 6

    See identical proteins and their annotated locations for NP_001271133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AF212245, AL121694, BU928810, BX161501, HY340214
    UniProtKB/TrEMBL
    G3V2R2
    Conserved Domains (1) summary
    pfam05571
    Location:9 → 213
    DUF766; Protein of unknown function (DUF766)

  6. NM_016475.5 → NP_057559.2  JNK1/MAPK8-associated membrane protein isoform 1

    See identical proteins and their annotated locations for NP_057559.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL121694, AL136696, BX161501, DC381037, HY340214
    Consensus CDS
    CCDS45116.1
    UniProtKB/Swiss-Prot
    B4DP67, Q6FIB6, Q6IAJ2, Q7Z5D4, Q86SY6, Q9H0Q6, Q9H2W0, Q9HAH5, Q9P055, Q9P0R3
    UniProtKB/TrEMBL
    B3KPC2
    Related
    ENSP00000479775.2, ENST00000616435.5
    Conserved Domains (1) summary
    pfam05571
    Location:9 → 300
    DUF766; Protein of unknown function (DUF766)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    59484517..59505410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449627.2 → XP_024305395.1  JNK1/MAPK8-associated membrane protein isoform X1

    UniProtKB/TrEMBL
    B3KPC2, G3V2M4
    Conserved Domains (1) summary
    pfam05571
    Location:23 → 314
    DUF766; Protein of unknown function (DUF766)

  2. XM_047431467.1 → XP_047287423.1  JNK1/MAPK8-associated membrane protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    53691449..53712359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376204.1 → XP_054232179.1  JNK1/MAPK8-associated membrane protein isoform X1

    UniProtKB/TrEMBL
    G3V2M4

  2. XM_054376205.1 → XP_054232180.1  JNK1/MAPK8-associated membrane protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P055.4 GenPept UniProtKB/Swiss-Prot:Q9P055

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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