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OSER1 oxidative stress responsive serine rich 1 [ Homo sapiens (human) ]

Gene ID: 51526, updated on 5-Mar-2024

Summary

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Official Symbol
OSER1provided by HGNC
Official Full Name
oxidative stress responsive serine rich 1provided by HGNC
Primary source
HGNC:HGNC:16105
See related
Ensembl:ENSG00000132823 AllianceGenome:HGNC:16105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Osr1; Perit1; HSPC207; C20orf111; dJ1183I21.1
Summary
Predicted to be involved in cellular response to hydrogen peroxide. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 25.7), bone marrow (RPKM 22.5) and 24 other tissues See more
Orthologs
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Genomic context

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See OSER1 in Genome Data Viewer
Location:
20q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44195939..44211810, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45930565..45949078, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42824579..42839411, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TOX high mobility group box family member 2 Neighboring gene RNA, 7SL, cytoplasmic 443, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42696545-42697061 Neighboring gene Sharpr-MPRA regulatory region 7745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42739928-42740441 Neighboring gene Sharpr-MPRA regulatory region 3924 Neighboring gene junctophilin 2 Neighboring gene uncharacterized LOC124904909 Neighboring gene JPH2 intron CAGE-defined T cell enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42795218-42795478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42806021-42806521 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:42809003-42809909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42810816-42811722 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:42832370-42833569 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42838821-42839440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12940 Neighboring gene OSER1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42860439-42861068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42875650-42876448 Neighboring gene Sharpr-MPRA regulatory region 13448 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:42900885-42901394 Neighboring gene ganglioside induced differentiation associated protein 1 like 1 Neighboring gene Sharpr-MPRA regulatory region 2613 Neighboring gene uncharacterized LOC124904910

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells. Xu Y, et al. RNA Biol, 2017 Feb. PMID 27982722, Free PMC Article
  2. Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. Clerk A, et al. Physiol Genomics, 2007 Apr 24. PMID 17148688
  3. Agrin has a pathological role in the progression of oral cancer. Rivera C, et al. Br J Cancer, 2018 Jun. PMID 29872149, Free PMC Article
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
  5. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxidative stress-responsive serine-rich protein 1
Names
oxidative stress-responsive 1
oxidative stress-responsive protein 1
peroxide-inducible transcript 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016470.8 → NP_057554.4  oxidative stress-responsive serine-rich protein 1

    See identical proteins and their annotated locations for NP_057554.4

    Status: VALIDATED

    Source sequence(s)
    AL035447, BC064973, BF109349, BI462161
    Consensus CDS
    CCDS13327.1
    UniProtKB/Swiss-Prot
    B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
    Related
    ENSP00000255174.2, ENST00000255174.3
    Conserved Domains (1) summary
    pfam05604
    Location:1 → 175
    DUF776; Protein of unknown function (DUF776)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    44195939..44211810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027873.2 → XP_016883362.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
    Conserved Domains (1) summary
    pfam05604
    Location:1 → 175
    DUF776; Protein of unknown function (DUF776)

  2. XM_011528854.4 → XP_011527156.1  oxidative stress-responsive serine-rich protein 1 isoform X2

    Conserved Domains (1) summary
    pfam05604
    Location:1 → 137
    DUF776; Protein of unknown function (DUF776)

  3. XM_047440191.1 → XP_047296147.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8

  4. XM_047440193.1 → XP_047296149.1  oxidative stress-responsive serine-rich protein 1 isoform X2

  5. XM_047440190.1 → XP_047296146.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8

  6. XM_047440192.1 → XP_047296148.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
    Related
    ENSP00000362061.1, ENST00000372970.6

  7. XM_011528853.4 → XP_011527155.1  oxidative stress-responsive serine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527155.1

    UniProtKB/Swiss-Prot
    B2RCK4, O95912, Q9NX31, Q9NZ84, Q9P0R8
    Conserved Domains (1) summary
    pfam05604
    Location:1 → 175
    DUF776; Protein of unknown function (DUF776)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    45930565..45949078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323485.1 → XP_054179460.1  oxidative stress-responsive serine-rich protein 1 isoform X1

  2. XM_054323488.1 → XP_054179463.1  oxidative stress-responsive serine-rich protein 1 isoform X2

  3. XM_054323486.1 → XP_054179461.1  oxidative stress-responsive serine-rich protein 1 isoform X1

  4. XM_054323484.1 → XP_054179459.1  oxidative stress-responsive serine-rich protein 1 isoform X1

  5. XM_054323487.1 → XP_054179462.1  oxidative stress-responsive serine-rich protein 1 isoform X1

  6. XM_054323489.1 → XP_054179464.1  oxidative stress-responsive serine-rich protein 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NX31.2 GenPept UniProtKB/Swiss-Prot:Q9NX31

Gene LinkOut

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