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CXXC5 CXXC finger protein 5 [ Homo sapiens (human) ]

Gene ID: 51523, updated on 5-Mar-2024

Summary

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Official Symbol
CXXC5provided by HGNC
Official Full Name
CXXC finger protein 5provided by HGNC
Primary source
HGNC:HGNC:26943
See related
Ensembl:ENSG00000171604 MIM:612752; AllianceGenome:HGNC:26943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CF5; WID; RINF; HSPC195
Summary
The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
5q31.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139647299..139683882)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (140172362..140208961)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139026884..139063467)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D2 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 15 Neighboring gene Sharpr-MPRA regulatory region 3558 Neighboring gene CRISPRi-validated cis-regulatory element chr5.3240 Neighboring gene Sharpr-MPRA regulatory region 4362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139017982-139018548 Neighboring gene H3 histone pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139030154-139030654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139038513-139039362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139040914-139041480 Neighboring gene CXXC5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23248 Neighboring gene uncharacterized LOC124901084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139053795-139054348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139058359-139059081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139064529-139065183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16425 Neighboring gene Sharpr-MPRA regulatory region 3182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139077525-139078494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139079969-139080794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139080795-139081619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139088825-139089815 Neighboring gene uncharacterized LOC124901085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139104350-139104850 Neighboring gene RNA, U6 small nuclear 236, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139117735-139118662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139121544-139122093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139122094-139122642 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:139123561-139124154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139125678-139126325 Neighboring gene PSD2 antisense RNA 1 Neighboring gene pleckstrin and Sec7 domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2). Ryu YC, et al. Cells, 2023 Feb 9. PMID 36831222, Free PMC Article
  2. Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway. Wang W, et al. J Biol Chem, 2023 Jan. PMID 36539038, Free PMC Article
  3. Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5. Sun Y, et al. Nat Cancer, 2022 Sep. PMID 35915262
  4. A prelude to the proximity interaction mapping of CXXC5. Ayaz G, et al. Sci Rep, 2021 Sep 2. PMID 34475492, Free PMC Article
  5. Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway. Yaşar P, et al. Sci Rep, 2016 Nov 25. PMID 27886276, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
    Title: Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
  2. Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/beta-catenin signaling pathway.
    Title: Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway.
  3. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2.
    Title: CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2).
  4. Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
    Title: Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
  5. Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
    Title: Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
  6. Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
    Title: Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
  7. A prelude to the proximity interaction mapping of CXXC5.
    Title: A prelude to the proximity interaction mapping of CXXC5.
  8. The epigenetic regulator RINF (CXXC5) maintains <i>SMAD7</i> expression in human immature erythroid cells and sustains red blood cells expansion.
    Title: The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
  9. CXXC5 is direct target gene of miR-32 which binds its 3'-UTR and inhibited the expression level of CXXC5 mRNA and protein.
    Title: miR-32 promotes esophageal squamous cell carcinoma metastasis by targeting CXXC5.
  10. CXXC5 is a a novel regulator and coordinator of TGF-beta, BMP4 and Wnt3a signaling. (Review)
    Title: CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
involved_in regulation of generation of precursor metabolites and energy IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CXXC-type zinc finger protein 5
Names
CXXC finger 5 protein
WT1-induced Inhibitor of Dishevelled
putative MAPK-activating protein PM08
putative NF-kappa-B-activating protein 102
retinoid-inducible nuclear factor

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317199.2 → NP_001304128.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
    Source sequence(s)
    AK024338, BC006428, DA291558
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  2. NM_001317200.2 → NP_001304129.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AK001782, BC006428
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Related
    ENSP00000427379.1, ENST00000511048.1
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  3. NM_001317201.2 → NP_001304130.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, DA705695
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  4. NM_001317202.2 → NP_001304131.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, DA264868
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  5. NM_001317203.2 → NP_001304132.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC113361, BC006428, BI763590, DA031665
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  6. NM_001317204.2 → NP_001304133.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC113361, BC006428, DA031665
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  7. NM_001317205.2 → NP_001304134.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, DA170918
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  8. NM_001317206.2 → NP_001304135.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, CB140368, HY181287
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  9. NM_001317207.2 → NP_001304136.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, CB140368
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  10. NM_001317208.2 → NP_001304137.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, DB458723
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  11. NM_001317209.2 → NP_001304138.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BI460400, HY012710
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  12. NM_001317210.2 → NP_001304139.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BI460400, HY043636
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  13. NM_001317211.2 → NP_001304140.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BI460400, HY015270
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

  14. NM_016463.9 → NP_057547.5  CXXC-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_057547.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AK024338, BC006428
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Related
    ENSP00000302543.3, ENST00000302517.8
    Conserved Domains (1) summary
    pfam02008
    Location:255 → 296
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    139647299..139683882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417302.1 → XP_047273258.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    140172362..140208961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352807.1 → XP_054208782.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7LFL8.1 GenPept UniProtKB/Swiss-Prot:Q7LFL8

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