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TEX264 testis expressed 264, ER-phagy receptor [ Homo sapiens (human) ]

Gene ID: 51368, updated on 3-Apr-2024

Summary

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Official Symbol
TEX264provided by HGNC
Official Full Name
testis expressed 264, ER-phagy receptorprovided by HGNC
Primary source
HGNC:HGNC:30247
See related
Ensembl:ENSG00000164081 MIM:620608; AllianceGenome:HGNC:30247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSIG11
Summary
Enables signaling receptor activity. Involved in protein-DNA covalent cross-linking repair. Acts upstream of or within reticulophagy. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum membrane; and replication fork. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 25.1), kidney (RPKM 16.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TEX264 in Genome Data Viewer
Location:
3p21.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51671252..51704323)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51702770..51735833)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51705268..51738339)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAD54 like 2 Neighboring gene RNA, U6atac small nuclear 29, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51696703-51697203 Neighboring gene uncharacterized LOC124906237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51712641-51713399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51721007-51721622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51724855-51725678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51725679-51726501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51737956-51738824 Neighboring gene RNA, 5S ribosomal pseudogene 132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51750466-51751323 Neighboring gene glutamate metabotropic receptor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51776905-51777405 Neighboring gene uncharacterized LOC105377087 Neighboring gene IQ motif containing F6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. An H, et al. Mol Cell, 2019 Jun 6. PMID 31006537, Free PMC Article
  2. TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. Fielden J, et al. Nat Commun, 2020 Mar 9. PMID 32152270, Free PMC Article
  3. Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Wang X, et al. Dev Dyn, 2008 Oct. PMID 18816836, Free PMC Article
  4. Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration. Majumder A, et al. Mol Cancer Res, 2022 Apr 1. PMID 35022314, Free PMC Article
  5. Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model. Van Acker ZP, et al. Cells, 2019 Aug 11. PMID 31405213, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TEX264 recognises both unmodified and SUMO1-modifed TOP1 and initiates TOP1cc repair by recruiting p97 and SPRTN.
    Title: TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
  2. A long intrinsically disordered region of TEX264 is required for its ER-phagy receptor function to bridge the gap between the ER and autophagosomal membranes independently of its amino acid sequence. These results suggest that TEX264 is a major ER-phagy receptor.
    Title: Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
  3. TEX264, an endoplasmic reticulum (ER)resident protein, remodels subdomainsof the ER into ring-like structures inassociation with ATG8 proteins uponnutrient stress, which then fuse withlysosomes for ER turnover.
    Title: TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13935, DKFZp451H0417

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein-DNA covalent cross-linking repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein-DNA covalent cross-linking repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within reticulophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reticulophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in replication fork IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-expressed protein 264
Names
testis expressed gene 264
testis-expressed sequence 264 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129884.3 → NP_001123356.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001123356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AA463493, AY358972, BP252919
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Related
    ENSP00000408186.1, ENST00000457573.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  2. NM_001243725.2 → NP_001230654.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001230654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AC099050, AY358972, BC008742
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Related
    ENSP00000378497.1, ENST00000395057.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  3. NM_001243726.2 → NP_001230655.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001230655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AC099050, AY358972, BC001592, BC008742
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Related
    ENSP00000398802.1, ENST00000416589.5
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  4. NM_001243727.3 → NP_001230656.1  testis-expressed protein 264 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA463493, AY358972, BG772477, HY149215
    Consensus CDS
    CCDS74945.1
    UniProtKB/TrEMBL
    A0A087WTU3
    Related
    ENSP00000478139.1, ENST00000614067.4

  5. NM_001278195.2 → NP_001265124.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_001265124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 4, 5, and 7 encode the same isoform (1).
    Source sequence(s)
    AA463493, AY358972, BG772477, BI826172
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Related
    ENSP00000477946.1, ENST00000611400.4
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  6. NM_015926.6 → NP_057010.1  testis-expressed protein 264 isoform 1

    See identical proteins and their annotated locations for NP_057010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, 4, 5, and 7 encode the same isoform.
    Source sequence(s)
    AA463493, AY358972, BG772477
    Consensus CDS
    CCDS2833.1
    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Related
    ENSP00000340969.5, ENST00000341333.10
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

RNA

  1. NR_024012.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA463493, AY358972, BG772477

  2. NR_103462.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA463493, AY358972, CB142778

  3. NR_103463.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA463493, AY358972, CB142778

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    51671252..51704323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448276.1 → XP_047304232.1  testis-expressed protein 264 isoform X1

  2. XM_047448278.1 → XP_047304234.1  testis-expressed protein 264 isoform X3

  3. XM_047448277.1 → XP_047304233.1  testis-expressed protein 264 isoform X2

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9

  4. XM_017006574.3 → XP_016862063.2  testis-expressed protein 264 isoform X5

  5. XM_006713197.5 → XP_006713260.1  testis-expressed protein 264 isoform X2

    See identical proteins and their annotated locations for XP_006713260.1

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  6. XM_011533805.3 → XP_011532107.1  testis-expressed protein 264 isoform X2

    See identical proteins and their annotated locations for XP_011532107.1

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  7. XM_006713195.4 → XP_006713258.1  testis-expressed protein 264 isoform X2

    See identical proteins and their annotated locations for XP_006713258.1

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9
    UniProtKB/TrEMBL
    Q53GI2
    Conserved Domains (1) summary
    cl01368
    Location:41 → 112
    GyrI-like; GyrI-like small molecule binding domain

  8. XM_006713198.2 → XP_006713261.1  testis-expressed protein 264 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    51702770..51735833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346776.1 → XP_054202751.1  testis-expressed protein 264 isoform X1

  2. XM_054346781.1 → XP_054202756.1  testis-expressed protein 264 isoform X3

  3. XM_054346777.1 → XP_054202752.1  testis-expressed protein 264 isoform X2

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9

  4. XM_054346783.1 → XP_054202758.1  testis-expressed protein 264 isoform X5

  5. XM_054346778.1 → XP_054202753.1  testis-expressed protein 264 isoform X2

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9

  6. XM_054346780.1 → XP_054202755.1  testis-expressed protein 264 isoform X2

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9

  7. XM_054346779.1 → XP_054202754.1  testis-expressed protein 264 isoform X2

    UniProtKB/Swiss-Prot
    B3KN87, Q9UKD7, Q9Y6I9

  8. XM_054346782.1 → XP_054202757.1  testis-expressed protein 264 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6I9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6I9

Gene LinkOut

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