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CHST15 carbohydrate sulfotransferase 15 [ Homo sapiens (human) ]

Gene ID: 51363, updated on 3-Apr-2024

Summary

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Official Symbol
CHST15provided by HGNC
Official Full Name
carbohydrate sulfotransferase 15provided by HGNC
Primary source
HGNC:HGNC:18137
See related
Ensembl:ENSG00000182022 MIM:608277; AllianceGenome:HGNC:18137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRAG; GALNAC4S-6ST
Summary
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in ovary (RPKM 9.9), spleen (RPKM 9.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q26.13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (124007668..124093598, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (124884870..124970782, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125767184..125853114, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984128 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10754 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_10761 and experimental_10770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125754121-125754683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125754684-125755246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125763289-125763856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125763857-125764422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125765089-125765590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125779847-125780352 Neighboring gene YBX2 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125780353-125780859 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125785865-125786861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125793037-125793559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125793560-125794081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125808477-125808977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125807976-125808476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125810019-125810519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125816334-125816862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125819356-125820031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125832991-125833492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125833493-125833992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4163 Neighboring gene uncharacterized LOC105378536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4165 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:125927283-125928482 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:125929584-125930147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125936098-125936598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125958373-125958874 Neighboring gene uncharacterized LOC107984184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population. Wang T, et al. Head Neck, 2023 Apr. PMID 36608057
  2. CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk. Chen Y, et al. Cell Death Dis, 2022 Jul 7. PMID 35798703, Free PMC Article
  3. CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer. Wang X, et al. Oncol Rep, 2020 Jan. PMID 31746400, Free PMC Article
  4. Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model. Takakura K, et al. PLoS One, 2015. PMID 26642349, Free PMC Article
  5. Role of GalNAc4S-6ST in astrocytic tumor progression. Kobayashi T, et al. PLoS One, 2013. PMID 23349846, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.
    Title: Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.
  2. CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.
    Title: CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.
  3. circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.
    Title: circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.
  4. Results showed that CHST15 is highly expressed in esophageal squamous cell carcinoma (ESCC) TE1 cell line and tissues. Its knockdown inhibited TE1 cell growth and proliferation, but induced cell apoptosis. These findings indicate that CHST15 may play an essential role in mediating the tumorigenicity of ESCC cells.
    Title: CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.
  5. The expression of HOTAIR closely correlated with the level of CHST15 protein.
    Title: Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.
  6. blockade CHST15 represses colonic fibrosis
    Title: Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.
  7. The direct action of CHST15 on the proliferation.
    Title: Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.
  8. Findings indicate that GalNAc4S-6ST mRNA expressed by astrocytic tumor cells is associated with poor patient prognosis.
    Title: Role of GalNAc4S-6ST in astrocytic tumor progression.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ60141, KIAA0598, MGC34346, DKFZp781H1369

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in hexose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hexose biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
carbohydrate sulfotransferase 15
Names
B cell RAG associated protein (GALNAC4S-6ST)
B-cell RAG-associated gene protein
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
hBRAG
NP_001257693.1
NP_001257694.1
NP_055678.2
NP_056976.2
XP_005269949.1
XP_005269950.1
XP_006717954.1
XP_011538159.1
XP_016871808.1
XP_016871809.1
XP_016871810.1
XP_047281280.1
XP_047281281.1
XP_047281282.1
XP_047281283.1
XP_047281284.1
XP_047281285.1
XP_047281286.1
XP_047281287.1
XP_047281288.1
XP_047281289.1
XP_047281290.1
XP_054222020.1
XP_054222021.1
XP_054222022.1
XP_054222023.1
XP_054222024.1
XP_054222025.1
XP_054222026.1
XP_054222027.1
XP_054222028.1
XP_054222029.1
XP_054222030.1
XP_054222031.1
XP_054222032.1
XP_054222033.1
XP_054222034.1
XP_054222035.1
XP_054222036.1
XP_054222037.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032891.1 RefSeqGene

    Range
    5010..90940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270764.2 → NP_001257693.1  carbohydrate sulfotransferase 15 isoform 1

    See identical proteins and their annotated locations for NP_001257693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and encodes isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AF026477, BC027908, BC075813, CR749804
    Consensus CDS
    CCDS7638.1
    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4
    UniProtKB/TrEMBL
    B4DH74
    Related
    ENSP00000402394.1, ENST00000435907.6
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  2. NM_001270765.2 → NP_001257694.1  carbohydrate sulfotransferase 15 isoform 2

    See identical proteins and their annotated locations for NP_001257694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AL683842, BC050540, BM977716
    Consensus CDS
    CCDS55731.1
    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:256 → 407
    Sulfotransfer_3; Sulfotransferase family

  3. NM_014863.4 → NP_055678.2  carbohydrate sulfotransferase 15 isoform 2

    See identical proteins and their annotated locations for NP_055678.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AK294961, AL683842, BM977716
    Consensus CDS
    CCDS55731.1
    UniProtKB/TrEMBL
    B4DH74
    Related
    ENSP00000485905.1, ENST00000628426.1
    Conserved Domains (1) summary
    cl21551
    Location:256 → 407
    Sulfotransfer_3; Sulfotransferase family

  4. NM_015892.5 → NP_056976.2  carbohydrate sulfotransferase 15 isoform 1

    See identical proteins and their annotated locations for NP_056976.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AF026477, BC027908, BC075813, BM193389
    Consensus CDS
    CCDS7638.1
    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4
    UniProtKB/TrEMBL
    B4DH74
    Related
    ENSP00000333947.6, ENST00000346248.7
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    124007668..124093598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425324.1 → XP_047281280.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  2. XM_047425327.1 → XP_047281283.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  3. XM_006717891.5 → XP_006717954.1  carbohydrate sulfotransferase 15 isoform X1

    See identical proteins and their annotated locations for XP_006717954.1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4
    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  4. XM_047425326.1 → XP_047281282.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  5. XM_047425328.1 → XP_047281284.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  6. XM_017016319.2 → XP_016871808.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4
    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:253 → 505
    Sulfotransfer_3; Sulfotransferase family

  7. XM_047425325.1 → XP_047281281.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  8. XM_005269892.5 → XP_005269949.1  carbohydrate sulfotransferase 15 isoform X2

    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:253 → 498
    Sulfotransfer_1; Sulfotransferase domain

  9. XM_005269893.4 → XP_005269950.1  carbohydrate sulfotransferase 15 isoform X3

    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:253 → 498
    Sulfotransfer_1; Sulfotransferase domain

  10. XM_047425330.1 → XP_047281286.1  carbohydrate sulfotransferase 15 isoform X2

  11. XM_017016320.2 → XP_016871809.1  carbohydrate sulfotransferase 15 isoform X2

    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:253 → 498
    Sulfotransfer_1; Sulfotransferase domain

  12. XM_017016321.2 → XP_016871810.1  carbohydrate sulfotransferase 15 isoform X3

    UniProtKB/TrEMBL
    B4DH74
    Conserved Domains (1) summary
    cl21551
    Location:253 → 498
    Sulfotransfer_1; Sulfotransferase domain

  13. XM_047425331.1 → XP_047281287.1  carbohydrate sulfotransferase 15 isoform X3

  14. XM_047425329.1 → XP_047281285.1  carbohydrate sulfotransferase 15 isoform X2

  15. XM_011539857.2 → XP_011538159.1  carbohydrate sulfotransferase 15 isoform X4

  16. XM_047425334.1 → XP_047281290.1  carbohydrate sulfotransferase 15 isoform X4

  17. XM_047425333.1 → XP_047281289.1  carbohydrate sulfotransferase 15 isoform X4

  18. XM_047425332.1 → XP_047281288.1  carbohydrate sulfotransferase 15 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    124884870..124970782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366046.1 → XP_054222021.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  2. XM_054366050.1 → XP_054222025.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  3. XM_054366045.1 → XP_054222020.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  4. XM_054366049.1 → XP_054222024.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  5. XM_054366047.1 → XP_054222022.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  6. XM_054366051.1 → XP_054222026.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  7. XM_054366048.1 → XP_054222023.1  carbohydrate sulfotransferase 15 isoform X1

    UniProtKB/Swiss-Prot
    O60338, O60474, Q7LFX5, Q86VM4

  8. XM_054366052.1 → XP_054222027.1  carbohydrate sulfotransferase 15 isoform X2

  9. XM_054366056.1 → XP_054222031.1  carbohydrate sulfotransferase 15 isoform X3

  10. XM_054366055.1 → XP_054222030.1  carbohydrate sulfotransferase 15 isoform X2

  11. XM_054366053.1 → XP_054222028.1  carbohydrate sulfotransferase 15 isoform X2

  12. XM_054366057.1 → XP_054222032.1  carbohydrate sulfotransferase 15 isoform X3

  13. XM_054366058.1 → XP_054222033.1  carbohydrate sulfotransferase 15 isoform X3

  14. XM_054366054.1 → XP_054222029.1  carbohydrate sulfotransferase 15 isoform X2

  15. XM_054366060.1 → XP_054222035.1  carbohydrate sulfotransferase 15 isoform X4

  16. XM_054366062.1 → XP_054222037.1  carbohydrate sulfotransferase 15 isoform X4

  17. XM_054366061.1 → XP_054222036.1  carbohydrate sulfotransferase 15 isoform X4

  18. XM_054366059.1 → XP_054222034.1  carbohydrate sulfotransferase 15 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7LFX5.1 GenPept UniProtKB/Swiss-Prot:Q7LFX5

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