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PDE1A phosphodiesterase 1A [ Homo sapiens (human) ]

Gene ID: 5136, updated on 3-Apr-2024

Summary

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Official Symbol
PDE1Aprovided by HGNC
Official Full Name
phosphodiesterase 1Aprovided by HGNC
Primary source
HGNC:HGNC:8774
See related
Ensembl:ENSG00000115252 MIM:171890; AllianceGenome:HGNC:8774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A
Summary
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
Expression
Broad expression in thyroid (RPKM 7.4), brain (RPKM 6.5) and 18 other tissues See more
Orthologs
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Genomic context

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See PDE1A in Genome Data Viewer
Location:
2q32.1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (182140041..182716797, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (182629098..183205733, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183004768..183388033, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1C Neighboring gene uncharacterized LOC102724288 Neighboring gene RNA, 5S ribosomal pseudogene 113 Neighboring gene NANOG hESC enhancer GRCh37_chr2:182975215-182975716 Neighboring gene uncharacterized LOC124907915 Neighboring gene RNA, 7SL, cytoplasmic 267, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:183364154-183364284 Neighboring gene NANOG hESC enhancer GRCh37_chr2:183364377-183364935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16835 Neighboring gene NANOG hESC enhancer GRCh37_chr2:183456476-183457108 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:183490526-183491063 Neighboring gene uncharacterized LOC124907914 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:183516578-183517777 Neighboring gene uncharacterized LOC101929976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:183581051-183581655 Neighboring gene DnaJ heat shock protein family (Hsp40) member C10 Neighboring gene MPRA-validated peak3967 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:183683314-183684194 Neighboring gene ribosomal protein L31 pseudogene 15 Neighboring gene uncharacterized LOC124907916 Neighboring gene frizzled related protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes. Tam CHT, et al. Diabetes Care, 2023 Jun 1. PMID 37125963, Free PMC Article
  2. PDE1A polymorphism contributes to the susceptibility of nephrolithiasis. Yang Z, et al. BMC Genomics, 2017 Dec 20. PMID 29262781, Free PMC Article
  3. Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques. Amin SA, et al. J Biomol Struct Dyn, 2018 Feb. PMID 28132591
  4. Phosphodiesterase 1 regulation is a key mechanism in vascular aging. Bautista Niño PK, et al. Clin Sci (Lond), 2015 Dec. PMID 26464516
  5. Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. Abusnina A, et al. Cell Signal, 2011 Jan. PMID 20807569

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.
    Title: Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.
  2. the p-substituted benzyl side chain at N2-position helps to enhance the PDE1 inhibitory profile. Depending on these observations, some new molecules are predicted that may possess better PDE1 inhibition
    Title: Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques.
  3. evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts.
    Title: PDE1A polymorphism contributes to the susceptibility of nephrolithiasis.
  4. Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness.
    Title: Phosphodiesterase 1 regulation is a key mechanism in vascular aging.
  5. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
    Title: Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
  6. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1.
    Title: Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Association of PDE11A global haplotype with major depression and antidepressant drug response.
  10. PDE1A is unlikely to play an important role in antidepressant outcome in this sample
    Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Names
61 kDa Cam-PDE
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
phosphodiesterase 1A, calmodulin-dependent
NP_001003683.1
NP_001245241.1
NP_001245242.1
NP_001245243.1
NP_001350800.1
NP_001382187.1
NP_001382188.1
NP_001382189.1
NP_001382190.1
NP_001382191.1
NP_001382192.1
NP_001382193.1
NP_001382194.1
NP_001382195.1
NP_001382196.1
NP_001382197.1
NP_001382198.1
NP_005010.2
XP_011509625.1
XP_011509626.1
XP_011509627.1
XP_011509628.1
XP_016859783.1
XP_047300644.1
XP_054198436.1
XP_054198437.1
XP_054198438.1
XP_054198439.1
XP_054198440.1
XP_054198441.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003683.3 → NP_001003683.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    See identical proteins and their annotated locations for NP_001003683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTRs, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS33344.1
    UniProtKB/Swiss-Prot
    D3DPG5, P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3
    UniProtKB/TrEMBL
    B7Z226
    Related
    ENSP00000387037.1, ENST00000410103.2
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. NM_001258312.3 → NP_001245241.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010888, AC011291, AC012500
    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:222 → 438
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:81 → 137
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. NM_001258313.3 → NP_001245242.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 4

    See identical proteins and their annotated locations for NP_001245242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and uses an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS58741.1
    UniProtKB/TrEMBL
    B7Z226
    Related
    ENSP00000309269.9, ENST00000351439.10
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  4. NM_001258314.3 → NP_001245243.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 5

    See identical proteins and their annotated locations for NP_001245243.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and uses an alternate start codon, compared to variant 1. The encoded isoform (5) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC011291
    Consensus CDS
    CCDS74612.1
    UniProtKB/TrEMBL
    B7Z7A2
    Related
    ENSP00000350858.3, ENST00000358139.6
    Conserved Domains (2) summary
    pfam00233
    Location:184 → 400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:43 → 99
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. NM_001363871.4 → NP_001350800.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has distinct N- terminus, compared to isoform 1.
    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS86900.1
    UniProtKB/TrEMBL
    B7Z226
    Related
    ENSP00000386767.1, ENST00000409365.6
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  6. NM_001395258.2 → NP_001382187.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS2285.1
    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  7. NM_001395259.2 → NP_001382188.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS2285.1
    UniProtKB/TrEMBL
    B7Z226
    Related
    ENSP00000512257.1, ENST00000482782.6
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  8. NM_001395260.2 → NP_001382189.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS2285.1
    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  9. NM_001395261.2 → NP_001382190.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS2285.1
    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  10. NM_001395262.1 → NP_001382191.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS33344.1
    UniProtKB/Swiss-Prot
    D3DPG5, P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3
    UniProtKB/TrEMBL
    B7Z226
    Related
    ENSP00000512258.1, ENST00000495511.2
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  11. NM_001395263.1 → NP_001382192.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS33344.1
    UniProtKB/Swiss-Prot
    D3DPG5, P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3
    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  12. NM_001395264.1 → NP_001382193.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (1) summary
    cd00077
    Location:202 → 373
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  13. NM_001395265.2 → NP_001382194.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    UniProtKB/TrEMBL
    B7Z226, B7Z3A7
    Conserved Domains (2) summary
    pfam00233
    Location:114 → 330
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:14 → 29
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  14. NM_001395266.1 → NP_001382195.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Conserved Domains (1) summary
    cd00077
    Location:218 → 389
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  15. NM_001395267.1 → NP_001382196.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Conserved Domains (1) summary
    cd00077
    Location:218 → 389
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  16. NM_001395268.1 → NP_001382197.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC010888, AC011291, AC012500
    Conserved Domains (1) summary
    cd00077
    Location:202 → 373
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  17. NM_001395269.1 → NP_001382198.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC011291
    Conserved Domains (1) summary
    cd00077
    Location:184 → 355
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  18. NM_005019.7 → NP_005010.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

    See identical proteins and their annotated locations for NP_005010.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC010888, AC011291, AC012500
    Consensus CDS
    CCDS2285.1
    UniProtKB/TrEMBL
    B7Z226
    Related
    ENSP00000410309.1, ENST00000435564.6
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    182140041..182716797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444688.1 → XP_047300644.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

  2. XM_011511326.3 → XP_011509628.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

    UniProtKB/TrEMBL
    B7Z7A2
    Conserved Domains (2) summary
    pfam00233
    Location:184 → 400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:43 → 99
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. XM_017004294.3 → XP_016859783.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

    UniProtKB/TrEMBL
    B7Z226

  4. XM_011511323.3 → XP_011509625.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. XM_011511325.4 → XP_011509627.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  6. XM_011511324.4 → XP_011509626.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

    UniProtKB/TrEMBL
    B7Z226
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RNA

  1. XR_007076388.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    182629098..183205733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342464.1 → XP_054198439.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

  2. XM_054342466.1 → XP_054198441.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

  3. XM_054342462.1 → XP_054198437.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

  4. XM_054342461.1 → XP_054198436.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

  5. XM_054342465.1 → XP_054198440.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

  6. XM_054342463.1 → XP_054198438.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

RNA

  1. XR_008486392.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54750.2 GenPept UniProtKB/Swiss-Prot:P54750

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