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ARL17A ADP ribosylation factor like GTPase 17A [ Homo sapiens (human) ]

Gene ID: 51326, updated on 3-Apr-2024

Summary

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Official Symbol
ARL17Aprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 17Aprovided by HGNC
Primary source
HGNC:HGNC:24096
See related
Ensembl:ENSG00000185829 AllianceGenome:HGNC:24096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARF1P2; ARL17P1
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 3.4), appendix (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
17q21.31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46500290..46579722, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47361441..47441293, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44586045..44657088, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37A Neighboring gene ADP ribosylation factor like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene RDM1 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 199, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:44704776-44705308 Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene vesicle-associated membrane protein 5-like Neighboring gene ribosomal protein S7 pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
ADP-ribosylation factor-like 17-like
Names
ADP-ribosylation factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113738.2 → NP_001107210.1  ADP-ribosylation factor-like 17-like isoform a

    See identical proteins and their annotated locations for NP_001107210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AB209344, AC138645
    Consensus CDS
    CCDS45718.1
    UniProtKB/Swiss-Prot
    B0AZR6, Q59FW5, Q8IVW1, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
    UniProtKB/TrEMBL
    A0A0G2JMH3, A8K0M5
    Related
    ENSP00000337478.6, ENST00000336125.6
    Conserved Domains (3) summary
    COG1100
    Location:13 → 88
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam15840
    Location:115 → 176
    ARL17; ADP-ribosylation factor-like protein 17
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001288811.1 → NP_001275740.1  ADP-ribosylation factor-like 17-like isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate 3' exon structure, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC138645, BX102203, DA761795, DA979569, DB065209, HY151357
    Consensus CDS
    CCDS74087.1
    UniProtKB/TrEMBL
    A0A087WVX3, A0A994J7P5
    Related
    ENSP00000331563.5, ENST00000329240.10
    Conserved Domains (3) summary
    COG1100
    Location:13 → 87
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam13900
    Location:93 → 118
    GVQW; Putative domain of unknown function
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001288812.1 → NP_001275741.1  ADP-ribosylation factor-like 17-like isoform b

    See identical proteins and their annotated locations for NP_001275741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate 3' exon structure, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 4 encode the same isoform (b).
    Source sequence(s)
    CA449330, DB027627, DB065209
    Consensus CDS
    CCDS45717.1
    UniProtKB/Swiss-Prot
    Q8IVW1
    Related
    ENSP00000516301.1, ENST00000706254.1
    Conserved Domains (1) summary
    cl21455
    Location:1 → 88
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001288813.1 → NP_001275742.1  ADP-ribosylation factor-like 17-like isoform d

    See identical proteins and their annotated locations for NP_001275742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC138645, BX102203, DB065209, DB241677
    Consensus CDS
    CCDS74086.1
    UniProtKB/TrEMBL
    A0A087WY76, I3L2E4
    Related
    ENSP00000481578.1, ENST00000622488.6
    Conserved Domains (1) summary
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001330244.1 → NP_001317173.1  ADP-ribosylation factor-like 17-like isoform e

    Status: VALIDATED

    Source sequence(s)
    AA911712, AC138645
    Consensus CDS
    CCDS82146.1
    UniProtKB/TrEMBL
    I3L1V5, I3L2E4
    Related
    ENSP00000459759.1, ENST00000573185.5
    Conserved Domains (2) summary
    COG1100
    Location:13 → 85
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cl21455
    Location:1 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. NM_001411134.1 → NP_001398063.1  ADP-ribosylation factor-like 17-like isoform f

    Status: VALIDATED

    Source sequence(s)
    AC138645
    Consensus CDS
    CCDS92351.1
    UniProtKB/TrEMBL
    I3L3L1
    Related
    ENSP00000516307.1, ENST00000706260.1

  7. NM_016632.2 → NP_057716.2  ADP-ribosylation factor-like 17-like isoform b

    See identical proteins and their annotated locations for NP_057716.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' exon structure, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 4 encode the same isoform (b).
    Source sequence(s)
    AB209344, AC138645, AF208864
    Consensus CDS
    CCDS45717.1
    UniProtKB/Swiss-Prot
    Q8IVW1
    Related
    ENSP00000416535.2, ENST00000445552.6
    Conserved Domains (1) summary
    cl21455
    Location:1 → 88
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    46500290..46579722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257439.6 → XP_005257496.1  ADP-ribosylation factor-like 17-like isoform X4

    See identical proteins and their annotated locations for XP_005257496.1

    UniProtKB/Swiss-Prot
    Q8IVW1
    Related
    ENSP00000516294.1, ENST00000706247.1
    Conserved Domains (1) summary
    cl21455
    Location:1 → 88
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_011524876.4 → XP_011523178.1  ADP-ribosylation factor-like 17-like isoform X2

    See identical proteins and their annotated locations for XP_011523178.1

    UniProtKB/TrEMBL
    A0A0G2JMH3, A0A994J5U5
    Related
    ENSP00000516303.1, ENST00000706256.1
    Conserved Domains (3) summary
    COG1100
    Location:13 → 88
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam15840
    Location:115 → 176
    ARL17; ADP-ribosylation factor-like protein 17
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_017024729.3 → XP_016880218.1  ADP-ribosylation factor-like 17-like isoform X2

    UniProtKB/TrEMBL
    A0A0G2JMH3, A0A994J5U5
    Related
    ENSP00000516305.1, ENST00000706258.1
    Conserved Domains (3) summary
    COG1100
    Location:13 → 88
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam15840
    Location:115 → 176
    ARL17; ADP-ribosylation factor-like protein 17
    cl21455
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_047436213.1 → XP_047292169.1  ADP-ribosylation factor-like 17-like isoform X1

    Related
    ENSP00000516298.1, ENST00000706251.1

  5. XM_047436214.1 → XP_047292170.1  ADP-ribosylation factor-like 17-like isoform X3

    UniProtKB/TrEMBL
    I3L1A0
    Related
    ENSP00000516304.1, ENST00000706257.1

RNA

  1. XR_934479.3 RNA Sequence

  2. XR_934475.4 RNA Sequence

  3. XR_934478.4 RNA Sequence

  4. XR_934477.4 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    976573..1099388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330125.1 → XP_054186100.1  ADP-ribosylation factor-like 17-like isoform X4

  2. XM_054330126.1 → XP_054186101.1  ADP-ribosylation factor-like 17-like isoform X4

  3. XM_054330124.1 → XP_054186099.1  ADP-ribosylation factor-like 17-like isoform X4

  4. XM_054330121.1 → XP_054186096.1  ADP-ribosylation factor-like 17-like isoform X2

    UniProtKB/TrEMBL
    A0A994J5U5

  5. XM_054330120.1 → XP_054186095.1  ADP-ribosylation factor-like 17-like isoform X2

    UniProtKB/TrEMBL
    A0A994J5U5

  6. XM_054330119.1 → XP_054186094.1  ADP-ribosylation factor-like 17-like isoform X1

  7. XM_054330122.1 → XP_054186097.1  ADP-ribosylation factor-like 17-like isoform X3

    UniProtKB/TrEMBL
    I3L1A0

  8. XM_054330123.1 → XP_054186098.1  ADP-ribosylation factor-like 17-like isoform X5

RNA

  1. XR_008485686.1 RNA Sequence

  2. XR_008485689.1 RNA Sequence

  3. XR_008485688.1 RNA Sequence

  4. XR_008485687.1 RNA Sequence

  5. XR_008485683.1 RNA Sequence

  6. XR_008485685.1 RNA Sequence

  7. XR_008485684.1 RNA Sequence

  8. XR_008485682.1 RNA Sequence

  9. XR_008485681.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47361441..47441293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316377.1 → XP_054172352.1  ADP-ribosylation factor-like 17-like isoform X4

  2. XM_054316376.1 → XP_054172351.1  ADP-ribosylation factor-like 17-like isoform X4

  3. XM_054316373.1 → XP_054172348.1  ADP-ribosylation factor-like 17-like isoform X2

    UniProtKB/TrEMBL
    A0A994J5U5

  4. XM_054316372.1 → XP_054172347.1  ADP-ribosylation factor-like 17-like isoform X1

  5. XM_054316374.1 → XP_054172349.1  ADP-ribosylation factor-like 17-like isoform X3

    UniProtKB/TrEMBL
    I3L1A0

  6. XM_054316375.1 → XP_054172350.1  ADP-ribosylation factor-like 17-like isoform X6

RNA

  1. XR_008484830.1 RNA Sequence

  2. XR_008484828.1 RNA Sequence

  3. XR_008484827.1 RNA Sequence

  4. XR_008484831.1 RNA Sequence

  5. XR_008484829.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_003653.1: Suppressed sequence

    Description
    NR_003653.1: This RefSeq was permanently suppressed because it is now thought that this gene expresses a protein.
Nucleotide Protein
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