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MRPL35 mitochondrial ribosomal protein L35 [ Homo sapiens (human) ]

Gene ID: 51318, updated on 7-Apr-2024

Summary

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Official Symbol
MRPL35provided by HGNC
Official Full Name
mitochondrial ribosomal protein L35provided by HGNC
Primary source
HGNC:HGNC:14489
See related
Ensembl:ENSG00000132313 MIM:611841; AllianceGenome:HGNC:14489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L35mt; bL35m; MRP-L35
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 19.0), colon (RPKM 15.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86199433..86213794)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86201527..86224659)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86426556..86440917)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene Sharpr-MPRA regulatory region 1812 Neighboring gene MPRA-validated peak3777 silencer Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene inner membrane mitochondrial protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16158 Neighboring gene microRNA 4779 Neighboring gene Sharpr-MPRA regulatory region 10968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:86457835-86458493 Neighboring gene Sharpr-MPRA regulatory region 10790 Neighboring gene receptor accessory protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11711 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:86487052-86487642 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:86551277-86551778 Neighboring gene U8 small nucleolar RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates Colorectal Cancer Cell Growth and Apoptosis. Zhang L, et al. Am J Pathol, 2019 May. PMID 30862482
  2. [IMAGE: molecular integration of the analysis of the human genome and its expression]. Auffray C, et al. C R Acad Sci III, 1995 Feb. PMID 7757816
  3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
  5. Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Kojima W, et al. Autophagy, 2021 Aug. PMID 33499712, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of MRPL35 promotes cell apoptosis and inhibits cell proliferation in non-small-cell lung cancer.
    Title: Knockdown of MRPL35 promotes cell apoptosis and inhibits cell proliferation in non-small-cell lung cancer.
  2. High MRPL35 expression Cooperate in Colorectal Cancer.
    Title: MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates Colorectal Cancer Cell Growth and Apoptosis.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein bL35m
Names
39S ribosomal protein L35, mitochondrial
mitochondrial large ribosomal subunit protein bL35m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363782.1 → NP_001350711.1  large ribosomal subunit protein bL35m isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct 3' coding region and 3' UTR compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus when compared to isoform a.
    Source sequence(s)
    AC009309
    Consensus CDS
    CCDS86858.1
    UniProtKB/TrEMBL
    D3YTC1
    Related
    ENSP00000386255.1, ENST00000409180.1
    Conserved Domains (1) summary
    pfam01632
    Location:102 → 161
    Ribosomal_L35p; Ribosomal protein L35

  2. NM_016622.4 → NP_057706.2  large ribosomal subunit protein bL35m isoform a

    See identical proteins and their annotated locations for NP_057706.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes isoform a.
    Source sequence(s)
    AC009309, AL832982, BG108475, BQ421154, BQ879834, BU195549, DA443416, DB245340, F11007, H11039
    Consensus CDS
    CCDS1988.1
    UniProtKB/Swiss-Prot
    A6NKV6, B2RB93, Q658U7, Q8WWA2, Q9NZE8
    Related
    ENSP00000338389.4, ENST00000337109.9
    Conserved Domains (1) summary
    pfam01632
    Location:102 → 161
    Ribosomal_L35p; Ribosomal protein L35

  3. NM_145644.3 → NP_663619.1  large ribosomal subunit protein bL35m isoform b

    See identical proteins and their annotated locations for NP_663619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1, that causes a frameshift and a shorter 3' UTR. The resulting isoform (b) has a shorter C-terminus when compared to isoform a.
    Source sequence(s)
    AK314577, AL832982, BC020651, BU195549, DA413384, F11007, H11039
    Consensus CDS
    CCDS1987.1
    UniProtKB/Swiss-Prot
    Q9NZE8
    Related
    ENSP00000254644.7, ENST00000254644.12
    Conserved Domains (1) summary
    pfam01632
    Location:102 → 161
    Ribosomal_L35p; Ribosomal protein L35

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    86199433..86213794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    86201527..86224659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342459.1 → XP_054198434.1  large ribosomal subunit protein bL35m isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZE8.3 GenPept UniProtKB/Swiss-Prot:Q9NZE8

Gene LinkOut

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