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NRN1 neuritin 1 [ Homo sapiens (human) ]

Gene ID: 51299, updated on 11-Apr-2024

Summary

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Official Symbol
NRN1provided by HGNC
Official Full Name
neuritin 1provided by HGNC
Primary source
HGNC:HGNC:17972
See related
Ensembl:ENSG00000124785 MIM:607409; AllianceGenome:HGNC:17972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRN; dJ380B8.2
Summary
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in brain (RPKM 29.3), fat (RPKM 22.7) and 14 other tissues See more
Orthologs
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Genomic context

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See NRN1 in Genome Data Viewer
Location:
6p25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (5997999..6007518, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (5866869..5876472, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (5998232..6007751, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986516 Neighboring gene RNA, 7SL, cytoplasmic 221, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:5937911-5938412 Neighboring gene uncharacterized LOC105374898 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:5998084-5999283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:5999848-6000753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:6003798-6004622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16878 Neighboring gene pyruvate kinase M1/2 pseudogene 5 Neighboring gene MPRA-validated peak5639 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:6169218-6169883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:6178115-6178614 Neighboring gene coagulation factor XIII A chain Neighboring gene microRNA 7853 Neighboring gene microRNA 5683 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:6218631-6219830 Neighboring gene uncharacterized LOC124901253

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease. Hurst C, et al. Mol Cell Proteomics, 2023 May. PMID 37024090, Free PMC Article
  2. NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches. Almodóvar-Payá C, et al. Int J Mol Sci, 2022 Jul 5. PMID 35806464, Free PMC Article
  3. Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer. Du W, et al. Cancer Sci, 2021 Jul. PMID 33931924, Free PMC Article
  4. Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment. Rahmawati E, et al. Int J Mol Sci, 2019 Sep 5. PMID 31491902, Free PMC Article
  5. Neurotrophins role in depressive symptoms and executive function performance: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample. Prats C, et al. J Affect Disord, 2017 Mar 15. PMID 28107668

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate.
    Title: Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate.
  2. Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease.
    Title: Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease.
  3. NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches.
    Title: NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches.
  4. NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss.
    Title: NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss.
  5. Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
    Title: Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
  6. The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer.
    Title: The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer.
  7. Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus.
    Title: Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus.
  8. The expression of NRN1 was significantly lower in women with ovarian endometriosis treated with GnRHa. These results suggest that NRN1 may be a biomarker response to the effect of GnRHa treatment for patients with ovarian endometriosis.
    Title: Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment.
  9. NRN1 is expressed more extensively in melanoma than in normal melanocytes and healthy tissue. Secreted NRN1 seems to play a role also in earlier phases of melanoma development as we can discover NRN1 over-expression to be associated to primary melanoma
    Title: The neurotrophin Neuritin1 (cpg15) is involved in melanoma migration, attachment independent growth, and vascular mimicry.
  10. results suggest that DTNBP1 and NRN1 genes show a joint effect on the risk for schizophrenia spectrum disorders. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate signalling suggests that our findings could be of value as a link to the schizophrenia aetiology.
    Title: Evidence of an epistatic effect between Dysbindin-1 and Neuritin-1 genes on the risk for schizophrenia spectrum disorders.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC44811

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in neuron projection extension IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuritin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278710.2 → NP_001265639.1  neuritin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001265639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC002683, BF970432, DB013243
    Consensus CDS
    CCDS4495.1
    UniProtKB/Swiss-Prot
    B2RA93, Q7Z4Y1, Q9NPD7
    Related
    ENSP00000484055.1, ENST00000616243.1
    Conserved Domains (1) summary
    pfam15056
    Location:31 → 117
    NRN1; Neuritin protein family

  2. NM_001278711.2 → NP_001265640.1  neuritin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK093824, BC002683, BX340783
    Consensus CDS
    CCDS75393.1
    UniProtKB/TrEMBL
    A0A087WWT2
    Related
    ENSP00000480483.1, ENST00000622188.4
    Conserved Domains (1) summary
    pfam15056
    Location:57 → 143
    NRN1; Neuritin protein family

  3. NM_016588.3 → NP_057672.1  neuritin isoform 1 precursor

    See identical proteins and their annotated locations for NP_057672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL136307, BC002683
    Consensus CDS
    CCDS4495.1
    UniProtKB/Swiss-Prot
    B2RA93, Q7Z4Y1, Q9NPD7
    Related
    ENSP00000244766.2, ENST00000244766.7
    Conserved Domains (1) summary
    pfam15056
    Location:31 → 117
    NRN1; Neuritin protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    5997999..6007518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715107.4 → XP_006715170.1  neuritin isoform X2

    Conserved Domains (1) summary
    pfam15056
    Location:22 → 108
    NRN1; Neuritin protein family

  2. XM_006715106.4 → XP_006715169.1  neuritin isoform X1

    Conserved Domains (1) summary
    pfam15056
    Location:92 → 178
    NRN1; Neuritin protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    5866869..5876472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355569.1 → XP_054211544.1  neuritin isoform X3

    UniProtKB/Swiss-Prot
    B2RA93, Q7Z4Y1, Q9NPD7

  2. XM_054355570.1 → XP_054211545.1  neuritin isoform X2

  3. XM_054355568.1 → XP_054211543.1  neuritin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPD7.1 GenPept UniProtKB/Swiss-Prot:Q9NPD7

Gene LinkOut

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