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CEND1 cell cycle exit and neuronal differentiation 1 [ Homo sapiens (human) ]

Gene ID: 51286, updated on 5-Mar-2024

Summary

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Official Symbol
CEND1provided by HGNC
Official Full Name
cell cycle exit and neuronal differentiation 1provided by HGNC
Primary source
HGNC:HGNC:24153
See related
Ensembl:ENSG00000184524 MIM:608213; AllianceGenome:HGNC:24153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM88
Summary
The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 37.5) and adrenal (RPKM 2.6) See more
Orthologs
mouse all
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Genomic context

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Location:
11p15.5
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (787115..790090, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (838549..841523, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (787115..790090, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3027 Neighboring gene uncharacterized LOC124900301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3028 Neighboring gene GATD1 divergent transcript Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:783107-783794 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:783795-784482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3029 Neighboring gene solute carrier family 25 member 22 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:794229-794747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:795266-795784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:796302-796820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:797857-798373 Neighboring gene proapoptotic nucleolar protein 1 Neighboring gene p53-induced death domain protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:804161-804858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4286

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students. Hou B, et al. J Affect Disord, 2021 Jan 1. PMID 33027701
  2. CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults. Park J, et al. Exp Gerontol, 2022 Apr. PMID 35045349
  3. Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons. Aravantinou-Fatorou K, et al. Int J Dev Biol, 2022. PMID 34549796
  4. BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. Katsimpardi L, et al. Stem Cells, 2008 Jul. PMID 18499894
  5. Characterization of the BM88 promoter and identification of an 88 bp fragment sufficient to drive neurone-specific expression. Papadodima O, et al. J Neurochem, 2005 Oct. PMID 16181419

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons.
    Title: Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons.
  2. CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults.
    Title: CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults.
  3. Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.
    Title: Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.
  4. BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels
    Title: BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90066, MGC34326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult walking behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cerebellar Purkinje cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebellar granular layer maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cerebellar granule cell precursor proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in radial glia guided migration of cerebellar granule cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell cycle exit and neuronal differentiation protein 1
Names
BM88 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016564.4 → NP_057648.2  cell cycle exit and neuronal differentiation protein 1

    See identical proteins and their annotated locations for NP_057648.2

    Status: REVIEWED

    Source sequence(s)
    AP006621, DA066200
    Consensus CDS
    CCDS7714.1
    UniProtKB/Swiss-Prot
    Q8N111, Q9NYM6
    UniProtKB/TrEMBL
    B2R7I3
    Related
    ENSP00000328336.4, ENST00000330106.5
    Conserved Domains (1) summary
    pfam15677
    Location:1 → 149
    CEND1; Cell cycle exit and neuronal differentiation protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    787115..790090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    838549..841523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N111.1 GenPept UniProtKB/Swiss-Prot:Q8N111

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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