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ZNF219 zinc finger protein 219 [ Homo sapiens (human) ]

Gene ID: 51222, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF219provided by HGNC
Official Full Name
zinc finger protein 219provided by HGNC
Primary source
HGNC:HGNC:13011
See related
Ensembl:ENSG00000165804 MIM:605036; AllianceGenome:HGNC:13011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP219
Summary
This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in fat (RPKM 12.4), colon (RPKM 6.8) and 22 other tissues See more
Orthologs
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Genomic context

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See ZNF219 in Genome Data Viewer
Location:
14q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21090077..21104722, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15287493..15302135, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21558236..21572881, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NDRG family member 2 Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 8 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5579 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21539187-21539808 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:21550650-21551849 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21552808-21554007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21554944-21555488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21555489-21556031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21558438-21559283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21559284-21560128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5581 Neighboring gene Sharpr-MPRA regulatory region 8150 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21565235-21565736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21566496-21566996 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21571456-21572200 Neighboring gene transmembrane protein 253 Neighboring gene RNA, U6 small nuclear 252, pseudogene Neighboring gene cytoskeleton associated protein 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF219 protects human lens epithelial cells against H(2)O(2)-induced injury via targeting SOX9 through activating AKT/GSK3β pathway. Guo Q, et al. Hum Exp Toxicol, 2021 Dec. PMID 34167360
  2. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. Sakai T, et al. DNA Res, 2000 Apr 28. PMID 10819330
  3. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. Sakai T, et al. DNA Res, 2003 Aug 31. PMID 14621294
  4. Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219. Clough RL, et al. J Neurochem, 2009 Sep. PMID 19549071
  5. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. Takigawa Y, et al. J Cell Sci, 2010 Nov 1. PMID 20940257

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF219, a novel transcriptional repressor, inhibits transcription of the prototype foamy virus by interacting with the viral LTR promoter.
    Title: ZNF219, a novel transcriptional repressor, inhibits transcription of the prototype foamy virus by interacting with the viral LTR promoter.
  2. ZNF219 protects human lens epithelial cells against H2O2-induced injury via targeting SOX9 through activating AKT/GSK3beta pathway.
    Title: ZNF219 protects human lens epithelial cells against H(2)O(2)-induced injury via targeting SOX9 through activating AKT/GSK3β pathway.
  3. regulates chondrocyte differentiation as a transcriptional partner of Sox9
    Title: The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.
  4. By using a random oligonucleotide selection assay and the electromobility gel shift assay, we have revealed that the ZNF219 protein recognizes two copies of CCCCCA.
    Title: Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in limb bud formation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 219

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053108.1 RefSeqGene

    Range
    11068..19646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001101672.2 → NP_001095142.1  zinc finger protein 219

    See identical proteins and their annotated locations for NP_001095142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK225811, BC000694
    Consensus CDS
    CCDS9568.1
    UniProtKB/Swiss-Prot
    D3DS16, Q53Y57, Q8IYC1, Q9BW28, Q9P2Y4
    UniProtKB/TrEMBL
    A8K3T5
    Related
    ENSP00000392401.2, ENST00000421093.6
    Conserved Domains (4) summary
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500 → 520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304 → 408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512 → 534
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001102454.2 → NP_001095924.1  zinc finger protein 219

    See identical proteins and their annotated locations for NP_001095924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK225811, AL161668, BC000694, DA013397
    Consensus CDS
    CCDS9568.1
    UniProtKB/Swiss-Prot
    D3DS16, Q53Y57, Q8IYC1, Q9BW28, Q9P2Y4
    UniProtKB/TrEMBL
    A8K3T5
    Related
    ENSP00000388558.2, ENST00000451119.6
    Conserved Domains (4) summary
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500 → 520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304 → 408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512 → 534
    zf-H2C2_2; Zinc-finger double domain

  3. NM_016423.3 → NP_057507.2  zinc finger protein 219

    See identical proteins and their annotated locations for NP_057507.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB015427, AL161668, BC000694, CB152705
    Consensus CDS
    CCDS9568.1
    UniProtKB/Swiss-Prot
    D3DS16, Q53Y57, Q8IYC1, Q9BW28, Q9P2Y4
    UniProtKB/TrEMBL
    A8K3T5
    Related
    ENSP00000354206.3, ENST00000360947.8
    Conserved Domains (4) summary
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:500 → 520
    zf-C2H2; Zinc finger, C2H2 type
    pfam04959
    Location:304 → 408
    ARS2; Arsenite-resistance protein 2
    pfam13465
    Location:512 → 534
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21090077..21104722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15287493..15302135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2Y4.2 GenPept UniProtKB/Swiss-Prot:Q9P2Y4

Gene LinkOut

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