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Uba2 ubiquitin-like modifier activating enzyme 2 [ Mus musculus (house mouse) ]

Gene ID: 50995, updated on 11-Apr-2024

Summary

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Official Symbol
Uba2provided by MGI
Official Full Name
ubiquitin-like modifier activating enzyme 2provided by MGI
Primary source
MGI:MGI:1858313
See related
Ensembl:ENSMUSG00000052997 AllianceGenome:MGI:1858313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arx; Sae2; UBA1; Ubl1a2; Uble1b
Summary
Enables SUMO activating enzyme activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in branchial arch; embryo; limb; and neural fold. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 54.7), CNS E14 (RPKM 34.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uba2 in Genome Data Viewer
Location:
7 B1; 7 19.41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33840121..33868014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34140697..34168590, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene WT1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_18578 Neighboring gene STARR-seq mESC enhancer starr_18579 Neighboring gene STARR-seq mESC enhancer starr_18581 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene programmed cell death 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and regulation of the mammalian SUMO-1 E1 enzyme. Azuma Y, et al. FASEB J, 2001 Aug. PMID 11481243
  2. Biotin-ubiquitin tagging of mammalian proteins in Escherichia coli. Wang T, et al. Protein Expr Purif, 2003 Jul. PMID 12821332
  3. SUMO conjugation and deconjugation. Schwienhorst I, et al. Mol Gen Genet, 2000 Jun. PMID 10905345
  4. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Ban R, et al. Genes Cells, 2011 Jun. PMID 21554500
  5. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. Takahashi H, et al. J Biol Chem, 2005 Feb 18. PMID 15569683

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to SUMO activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SUMO activating enzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUMO-activating enzyme subunit 2
Names
SUMO1 activating enzyme subunit 2
Sumo-1 activating enzyme subunit 2
anthracycline-associated resistance ARX
ubiquitin-like 1 (sentrin) activating enzyme E1B
ubiquitin-like 1 (sentrin) activating enzyme subunit 2
ubiquitin-like 1-activating enzyme E1B
NP_001405401.1
NP_001405402.1
NP_001405403.1
NP_001405405.1
NP_057891.1
XP_017177837.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418472.1 → NP_001405401.1  SUMO-activating enzyme subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX537302

  2. NM_001418473.1 → NP_001405402.1  SUMO-activating enzyme subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX537302

  3. NM_001418474.1 → NP_001405403.1  SUMO-activating enzyme subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX537302

  4. NM_001418476.1 → NP_001405405.1  SUMO-activating enzyme subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX537302

  5. NM_016682.3 → NP_057891.1  SUMO-activating enzyme subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_057891.1

    Status: VALIDATED

    Source sequence(s)
    BX537302
    Consensus CDS
    CCDS21136.1
    UniProtKB/Swiss-Prot
    Q3TQN3, Q3U819, Q3U9J5, Q8BVX9, Q9Z1F9
    Related
    ENSMUSP00000099807.5, ENSMUST00000102746.11
    Conserved Domains (4) summary
    cd01489
    Location:19 → 442
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:9 → 175
    ThiF; ThiF family
    pfam14732
    Location:450 → 536
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:547 → 633
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

RNA

  1. NR_184752.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX537302

  2. NR_184753.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX537302

  3. NR_184754.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX537302

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    33840121..33868014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322348.3 → XP_017177837.1  SUMO-activating enzyme subunit 2 isoform X1

    Conserved Domains (3) summary
    cd01489
    Location:19 → 442
    Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam14732
    Location:450 → 536
    UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    pfam16195
    Location:549 → 578
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1F9.1 GenPept UniProtKB/Swiss-Prot:Q9Z1F9

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