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PCBP2 poly(rC) binding protein 2 [ Homo sapiens (human) ]

Gene ID: 5094, updated on 11-Apr-2024

Summary

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Official Symbol
PCBP2provided by HGNC
Official Full Name
poly(rC) binding protein 2provided by HGNC
Primary source
HGNC:HGNC:8648
See related
Ensembl:ENSG00000197111 MIM:601210; AllianceGenome:HGNC:8648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPE2; HNRNPE2; hnRNP-E2
Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Expression
Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53452102..53481162)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53418139..53447209)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53845886..53874946)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53834490-53835255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4510 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4513 Neighboring gene proline rich 13 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53876139-53876652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4514 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene Sharpr-MPRA regulatory region 1043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6423 Neighboring gene ATF7-NPFF readthrough Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of a novel LncRNA AC104958.2 stabilized by PCBP2 promotes proliferation and microvascular invasion in hepatocellular carcinoma. Ma Z, et al. Exp Cell Res, 2021 Oct 1. PMID 34418457
  2. Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer. Yuan C, et al. Biomed Pharmacother, 2021 Jul. PMID 34233389
  3. PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis. Yoshimura M, et al. J Neuropathol Exp Neurol, 2021 Feb 22. PMID 33313661
  4. High expression of PCBP2 is associated with progression and poor prognosis in patients with glioblastoma. Luo K, et al. Biomed Pharmacother, 2017 Oct. PMID 28787701
  5. Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. Davidson YS, et al. Acta Neuropathol Commun, 2017 Jun 30. PMID 28666471, Free PMC Article

See all (287) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.
    Title: Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.
  2. Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
    Title: Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
  3. The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
    Title: The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
  4. MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
    Title: MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
  5. PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
    Title: PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
  6. Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.
    Title: Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.
  7. PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis.
    Title: PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis.
  8. Upregulation of a novel LncRNA AC104958.2 stabilized by PCBP2 promotes proliferation and microvascular invasion in hepatocellular carcinoma.
    Title: Upregulation of a novel LncRNA AC104958.2 stabilized by PCBP2 promotes proliferation and microvascular invasion in hepatocellular carcinoma.
  9. PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
    Title: PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
  10. Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer.
    Title: Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer.
Submit: New GeneRIF Correction See all GeneRIFs (74)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) E2 PubMed
Tat tat Poly(rC) binding protein 2 (PCBP2) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC110998

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cGAS/STING signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral RNA genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
poly(rC)-binding protein 2
Names
alpha-CP2
epididymis secretory sperm binding protein
heterogeneous nuclear ribonucleoprotein E2
heterogenous nuclear ribonucleoprotein E2
hnRNP E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098620.3 → NP_001092090.1  poly(rC)-binding protein 2 isoform c

    See identical proteins and their annotated locations for NP_001092090.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, BF509278
    Consensus CDS
    CCDS44903.1
    UniProtKB/TrEMBL
    H3BRU6
    Related
    ENSP00000352228.5, ENST00000359282.9
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:250 → 325
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  2. NM_001128911.2 → NP_001122383.1  poly(rC)-binding protein 2 isoform d

    See identical proteins and their annotated locations for NP_001122383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is one amino acid shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, BF509278, X78136
    Consensus CDS
    CCDS44901.1
    UniProtKB/Swiss-Prot
    A8K7X6, B4DXP5, F8VYL7, G3V0E8, I6L8F9, Q15366, Q32Q82, Q59HD4, Q68Y55, Q6IPF4, Q6PKG5
    UniProtKB/TrEMBL
    H3BRU6
    Related
    ENSP00000408949.2, ENST00000439930.7
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:284 → 359
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  3. NM_001128912.2 → NP_001122384.1  poly(rC)-binding protein 2 isoform e

    See identical proteins and their annotated locations for NP_001122384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is five amino acids shorter compared to isoform a.
    Source sequence(s)
    AB188306, AB208825, AC023509, AK130583, BF509278
    Consensus CDS
    CCDS55830.1
    UniProtKB/TrEMBL
    H3BRU6
    Related
    ENSP00000448927.2, ENST00000552296.6
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:280 → 355
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  4. NM_001128913.2 → NP_001122385.1  poly(rC)-binding protein 2 isoform f

    See identical proteins and their annotated locations for NP_001122385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, BC107688, BF509278
    Consensus CDS
    CCDS44902.1
    UniProtKB/TrEMBL
    H3BRU6
    Related
    ENSP00000394116.1, ENST00000447282.5
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:254 → 329
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  5. NM_001128914.2 → NP_001122386.1  poly(rC)-binding protein 2 isoform g

    See identical proteins and their annotated locations for NP_001122386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, AK225357, BF509278
    Consensus CDS
    CCDS44904.1
    UniProtKB/TrEMBL
    H3BRU6
    Related
    ENSP00000390304.1, ENST00000437231.5
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:237 → 312
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  6. NM_005016.6 → NP_005007.2  poly(rC)-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_005007.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB188306, AC023509, AK130583, BC035420, BF509278
    Consensus CDS
    CCDS44900.1
    UniProtKB/TrEMBL
    A0A384N6B9, H3BRU6
    Related
    ENSP00000352438.5, ENST00000359462.9
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:285 → 360
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

  7. NM_031989.5 → NP_114366.1  poly(rC)-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_114366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB188306, AC023509, AK130583, AK292141, BF509278
    Consensus CDS
    CCDS8859.1
    UniProtKB/TrEMBL
    H3BRU6
    Related
    ENSP00000448762.2, ENST00000546463.6
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281 → 356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    53452102..53481162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    53418139..53447209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15366.1 GenPept UniProtKB/Swiss-Prot:Q15366

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