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Mink1 misshapen-like kinase 1 (zebrafish) [ Mus musculus (house mouse) ]

Gene ID: 50932, updated on 11-Apr-2024

Summary

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Official Symbol
Mink1provided by MGI
Official Full Name
misshapen-like kinase 1 (zebrafish)provided by MGI
Primary source
MGI:MGI:1355329
See related
Ensembl:ENSMUSG00000020827 AllianceGenome:MGI:1355329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B55; MINK; Ysk2; Map4k6
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in positive regulation of JNK cascade; positive regulation of p38MAPK cascade; and protein phosphorylation. Acts upstream of or within negative thymic T cell selection. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 44.5), frontal lobe adult (RPKM 42.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 43.0 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70452272..70505309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70561580..70614482)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40193 Neighboring gene phospholipase D2 Neighboring gene STARR-seq mESC enhancer starr_29877 Neighboring gene predicted gene, 51905 Neighboring gene RIKEN cDNA 4930544D05 gene Neighboring gene cholinergic receptor, nicotinic, epsilon polypeptide Neighboring gene predicted gene 12315

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. Fu G, et al. J Exp Med, 2017 May 1. PMID 28400474, Free PMC Article
  2. Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation. Yue M, et al. Blood, 2016 Feb 18. PMID 26598717
  3. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. Dan I, et al. FEBS Lett, 2000 Mar 3. PMID 10708748
  4. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. Hu Y, et al. J Biol Chem, 2004 Dec 24. PMID 15469942
  5. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Nonaka H, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930710

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFbeta signaling.
    Title: Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFβ signaling.
  2. a critical regulator of Th17 cell differentiation
    Title: Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1.
  3. using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing premature SAC silencing
    Title: Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint.
  4. MINK1 may be an important signaling molecule that mediates mitogen-activated protein kinase signaling and participates in platelet activation and thrombus formation.
    Title: Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
misshapen-like kinase 1
Names
GCK family kinase MiNK
MAPK/ERK kinase kinase kinase 6
MEK kinase kinase 6
MEKKK 6
Misshapen/NIKs-related kinase
Yeast Sps1/Ste20-related kinase 2
misshapen/NIK-related kinase
NP_001039424.1
NP_001039429.1
NP_001390484.1
NP_001390485.1
NP_001390486.1
NP_057922.2
NP_795712.2
XP_006533740.1
XP_006533741.1
XP_017170134.1
XP_017170135.1
XP_030101977.1
XP_030101978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045959.2 → NP_001039424.1  misshapen-like kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS36205.1
    UniProtKB/TrEMBL
    Q5SXG1, Q5SXG3
    Related
    ENSMUSP00000072649.8, ENSMUST00000072873.14
    Conserved Domains (3) summary
    smart00036
    Location:1019 → 1317
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  2. NM_001045964.2 → NP_001039429.1  misshapen-like kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_001039429.1

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS48837.1
    UniProtKB/TrEMBL
    G3X9G2, Q5SXG1
    Related
    ENSMUSP00000072091.7, ENSMUST00000072237.13
    Conserved Domains (3) summary
    smart00036
    Location:1026 → 1324
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  3. NM_001403555.1 → NP_001390484.1  misshapen-like kinase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL592547

  4. NM_001403556.1 → NP_001390485.1  misshapen-like kinase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL592547

  5. NM_001403557.1 → NP_001390486.1  misshapen-like kinase 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL592547

  6. NM_016713.3 → NP_057922.2  misshapen-like kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_057922.2

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS24954.1
    UniProtKB/TrEMBL
    Q5SXG1
    Related
    ENSMUSP00000099618.5, ENSMUST00000102558.11
    Conserved Domains (3) summary
    smart00036
    Location:982 → 1280
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  7. NM_176893.3 → NP_795712.2  misshapen-like kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_795712.2

    Status: VALIDATED

    Source sequence(s)
    AL592547
    Consensus CDS
    CCDS24955.1
    UniProtKB/Swiss-Prot
    Q5SXG2, Q921M6, Q9JM52, Q9JM92
    UniProtKB/TrEMBL
    Q5SXG1
    Related
    ENSMUSP00000099619.5, ENSMUST00000102559.11
    Conserved Domains (3) summary
    smart00036
    Location:990 → 1288
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70452272..70505309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533677.4 → XP_006533740.1  misshapen-like kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006533740.1

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (3) summary
    smart00036
    Location:1056 → 1354
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:539 → 835
    PHA03307; transcriptional regulator ICP4; Provisional
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  2. XM_006533678.4 → XP_006533741.1  misshapen-like kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006533741.1

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (3) summary
    smart00036
    Location:1055 → 1353
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:539 → 835
    PHA03307; transcriptional regulator ICP4; Provisional
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  3. XM_017314645.3 → XP_017170134.1  misshapen-like kinase 1 isoform X6

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (2) summary
    smart00036
    Location:1018 → 1316
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  4. XM_017314646.3 → XP_017170135.1  misshapen-like kinase 1 isoform X7

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (2) summary
    smart00036
    Location:1011 → 1309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  5. XM_030246117.2 → XP_030101977.1  misshapen-like kinase 1 isoform X8

    UniProtKB/TrEMBL
    Q5SXG1
    Conserved Domains (3) summary
    smart00036
    Location:981 → 1279
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:515 → 788
    PHA03307; transcriptional regulator ICP4; Provisional
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  6. XM_030246118.1 → XP_030101978.1  misshapen-like kinase 1 isoform X9

    UniProtKB/TrEMBL
    F7AMS7
    Conserved Domains (2) summary
    smart00036
    Location:745 → 1043
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    PHA03307
    Location:228 → 524
    PHA03307; transcriptional regulator ICP4; Provisional

RNA

  1. XR_388490.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JM52.3 GenPept UniProtKB/Swiss-Prot:Q9JM52

Gene LinkOut

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