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Nasp nuclear autoantigenic sperm protein (histone-binding) [ Mus musculus (house mouse) ]

Gene ID: 50927, updated on 5-Mar-2024

Summary

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Official Symbol
Naspprovided by MGI
Official Full Name
nuclear autoantigenic sperm protein (histone-binding)provided by MGI
Primary source
MGI:MGI:1355328
See related
Ensembl:ENSMUSG00000028693 AllianceGenome:MGI:1355328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epcs32; Nasp-T; D4Ertd767e; 5033430J04Rik
Summary
Enables histone binding activity. Involved in G1/S transition of mitotic cell cycle; blastocyst development; and histone exchange. Acts upstream of or within DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; extraembryonic component; lung; metanephros; and rest of cerebellum marginal layer. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 97.7), testis adult (RPKM 45.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.24 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116458249..116488894, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116601052..116628676, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11140 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene RIKEN cDNA C530005A16 gene Neighboring gene coiled-coil domain containing 17 Neighboring gene STARR-positive B cell enhancer ABC_E4648 Neighboring gene STARR-positive B cell enhancer ABC_E4649 Neighboring gene STARR-positive B cell enhancer ABC_E7980 Neighboring gene aldo-keto reductase family 1, member A1 Neighboring gene predicted gene, 25137

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A]. Zhang Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2022 Jul. PMID 35786450
  2. A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse. Zhang J, et al. Mediators Inflamm, 2021. PMID 34720750, Free PMC Article
  3. A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus. Ju J, et al. Front Immunol, 2019. PMID 31001259, Free PMC Article
  4. Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells. Richardson RT, et al. Gene, 2006 Apr 12. PMID 16423470
  5. Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei. Alekseev OM, et al. J Biol Chem, 2005 Jan 28. PMID 15533935

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway.
    Title: sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway.
  2. [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A].
    Title: [Hepatic fibrosis aggravation in nuclear autoantigenic sperm protein (NASP) mutant mice induced by concanavalin A].
  3. A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
    Title: A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
  4. A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus.
    Title: A Variant of the Histone-Binding Protein sNASP Contributes to Mouse Lupus.
  5. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
    Title: MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
  6. NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation; therefore, tNASP's role is to provide the functional link between linker histones and cell cycle progression during meiosis.
    Title: Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.
  7. in the cytoplasm linker histones are bound to a complex containing NASP and HSP90 whose ATPase activity is stimulated by binding NASP
    Title: Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei.
  8. NASP and the linker histones are key players in the assembly of chromatin after DNA replication
    Title: Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation.
  9. overexpression affects progression through cell cycle
    Title: Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle.
  10. Sp1 and Ets are the primary activators of the NASP promoter.
    Title: Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone chaperone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication-dependent chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blastocyst development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear autoantigenic sperm protein
Names
somatic histone binding protein NASP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081475.1 → NP_001074944.1  nuclear autoantigenic sperm protein isoform 1

    See identical proteins and their annotated locations for NP_001074944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
    Source sequence(s)
    AK083333, AL669953
    Consensus CDS
    CCDS38852.1
    UniProtKB/TrEMBL
    B1AU76
    Related
    ENSMUSP00000030457.6, ENSMUST00000030457.12
    Conserved Domains (3) summary
    sd00006
    Location:203 → 231
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:201 → 277
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:203 → 240
    SHNi-TPR

  2. NM_001284229.1 → NP_001271158.1  nuclear autoantigenic sperm protein isoform 3

    See identical proteins and their annotated locations for NP_001271158.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
    Source sequence(s)
    AF095722, AK083333, AL669953
    Consensus CDS
    CCDS71451.1
    UniProtKB/Swiss-Prot
    Q99MD9
    Related
    ENSMUSP00000079946.5, ENSMUST00000081182.5
    Conserved Domains (3) summary
    sd00006
    Location:176 → 204
    TPR; TPR repeat [structural motif]
    pfam10516
    Location:176 → 213
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:173 → 250
    TPR_12; Tetratricopeptide repeat

  3. NM_016777.3 → NP_058057.3  nuclear autoantigenic sperm protein isoform 2

    See identical proteins and their annotated locations for NP_058057.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AL669953, BX004835
    Consensus CDS
    CCDS18513.1
    UniProtKB/Swiss-Prot
    O35499, O88993, Q3V150, Q99KE9, Q99MD9
    UniProtKB/TrEMBL
    B1AU75
    Related
    ENSMUSP00000030456.8, ENSMUST00000030456.14
    Conserved Domains (4) summary
    TIGR00927
    Location:250 → 505
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00006
    Location:528 → 556
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:526 → 602
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:528 → 565
    SHNi-TPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116458249..116488894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253656.2 → XP_030109516.1  nuclear autoantigenic sperm protein isoform X1

    UniProtKB/Swiss-Prot
    O35499, O88993, Q3V150, Q99KE9, Q99MD9
    UniProtKB/TrEMBL
    B1AU75
    Conserved Domains (4) summary
    TIGR00927
    Location:250 → 505
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00006
    Location:528 → 556
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:526 → 602
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:528 → 565
    SHNi-TPR
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MD9.2 GenPept UniProtKB/Swiss-Prot:Q99MD9

Gene LinkOut

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