Neu3 neuraminidase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neu3provided by MGI
Official Full Name: neuraminidase 3provided by MGI
Primary source: MGI:MGI:1355305
See related: Ensembl:ENSMUSG00000035239 AllianceGenome:MGI:1355305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables exo-alpha-(2->3)-sialidase activity. Involved in ganglioside catabolic process. Located in early endosome membrane; external side of plasma membrane; and recycling endosome membrane. Is expressed in brain. Orthologous to human NEU3 (neuraminidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 13.1), ovary adult (RPKM 8.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 54.15 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99460646..99477579, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99811434..99828457, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis.
Title: Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis.
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning.
Title: Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning.
NEU3 participates in fibrosis.
Title: Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3(-/-)) mice.
de-toxification of lipopolysaccharide by circulating alkaline phosphatase (AP) isozymes was incapacitated during sepsis caused by Salmonella or E. coli through activation of host Toll-like receptor 4, which triggered Neu1 and Neu3 neuraminidase induction.
Title: Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis.
NEU1/3 activity mediates IL-6 production in lupus-prone mesangial cells possibly through an IgG-receptor complex signaling pathway.
Title: Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells.
Absence of Neu3 and Neu4 leads to defects in cell adhesion and differentiation of epithelial cells resulting in aberrant tubular offshoots that fail to remain connected with the main duct and male infertility. Hence Neu3 and Neu 4 play an essential role in the guidance of epithelial cells during early embryonic formation.
Title: Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model.
the expression of neuraminidases in induced regulatory T (iTreg) cells was investigated in comparison with that in other T-cell subsets and concluded that Neu3 contributes to the differentiation of iTreg cells by upregulation of FoxP3.
Title: Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells.
radiographs revealed abnormalities in the skeletal bones of the Hexa(-/-)Neu3(-/-) mice
Title: Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.
These results suggest that NEU3 activity on exosome glycans enhances the dynamic biological behavior of these small extracellular vesicles by modifying the negative charge and steric hindrance of their glycocalyx, and that the presence of NEU3 on the exosomal surface could represent a useful marker for the detection of these nanovesicles
Title: Exosomes Secreted by HeLa Cells Shuttle on Their Surface the Plasma Membrane-Associated Sialidase NEU3.
These results provide the first in vivo evidence that neuraminidases 3 and 4 have important roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin bodies.
Title: Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Neu3 (e-PCR), detects polymorphism
- UniSTS:508014

NoName (e-PCR)
- UniSTS:492263

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-sialidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables exo-alpha-(2->3)-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-(2->3)-sialidase activity	ISO Inferred from Sequence Orthology more info
enables exo-alpha-(2->6)-sialidase activity	IEA Inferred from Electronic Annotation more info
enables exo-alpha-(2->8)-sialidase activity	ISO Inferred from Sequence Orthology more info
enables exo-alpha-sialidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ganglioside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ganglioside catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ganglioside catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sialidase-3

Names: N-acetyl-alpha-neuraminidase 3; Sialidase 3 (Membrane sialidase) (Ganglioside sialidase) (N-acetyl-alpha-neuraminidase 3); ganglioside sialidase; membrane sialidase

NP_001405392.1

EC 3.2.1.18

NP_057929.1

EC 3.2.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.