Tmod3 tropomodulin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmod3provided by MGI
Official Full Name: tropomodulin 3provided by MGI
Primary source: MGI:MGI:1355315
See related: Ensembl:ENSMUSG00000058587 AllianceGenome:MGI:1355315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UTMOD; U-Tmod
Summary: Enables tropomyosin binding activity. Acts upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in striated muscle thin filament. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 9.7), placenta adult (RPKM 7.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.3 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (75405066..75466939, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (75497784..75559657, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia.
Title: Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia.
Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton.
Title: Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton.
Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
Title: Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
Tmod3 plays crucial roles in oocyte maturation
Title: Tropomodulin-3 is essential in asymmetric division during mouse oocyte maturation.
Tmod3 is a novel Akt2 effector that mediates insulin-induced cortical actin remodelling and subsequent GLUT4 membrane insertion
Title: Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.
Loss of TMOD3 is associated with hemorrhage, defect in actin polymerization, organization and platelet biogenesis.
Title: Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.
Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization.
Title: Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.
Tmod3-/- embryos are defective in definitive erythropoiesis with reduced progenitors, impaired terminal differentiation, and enucleation.
Title: Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.
Western blots of Tmod1-null RBCs confirm the absence of Tmod1 and show the presence of Tmod3, which is normally not present in RBCs.
Title: Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.
Tmod3 and -4 localize to pointed ends in Tmod1-null adult muscle
Title: Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1528 (e-PCR)
- UniSTS:15956

RH135633 (e-PCR)
- UniSTS:164701

D9Mit262 (e-PCR), detects polymorphism
- UniSTS:131831

Tmod3 (e-PCR), detects polymorphism
- UniSTS:546047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pointed-end actin filament capping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle thin filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tropomodulin-3

Names: tropomodulin 3; ubiquitous tropomodulin; ubiquitous tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357828.1 → NP_001344757.1 tropomodulin-3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC115880, AC123832

UniProtKB/TrEMBL

Q8C3Z3

Conserved Domains (1) summary

cl26161
Location:60 → 172

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_016963.2 → NP_058659.1 tropomodulin-3 isoform 1

See identical proteins and their annotated locations for NP_058659.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AF237630, AK147017, BY067594

Consensus CDS

CCDS23344.1

UniProtKB/Swiss-Prot

Q3TIT1, Q9JHJ0

UniProtKB/TrEMBL

Q3TFA9

Related

ENSMUSP00000072087.8, ENSMUST00000072232.9

Conserved Domains (2) summary

cd00116
Location:199 → 311

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam03250
Location:5 → 144

Tropomodulin; Tropomodulin