Tmod4 tropomodulin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmod4provided by MGI
Official Full Name: tropomodulin 4provided by MGI
Primary source: MGI:MGI:1355285
See related: Ensembl:ENSMUSG00000005628 AllianceGenome:MGI:1355285
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTMOD; Sk-Tmod
Summary: Enables tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. Is expressed in diaphragm; lung; and vertebral axis musculature. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in mammary gland adult (RPKM 7.1), heart adult (RPKM 2.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95030110..95036520)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95122799..95129209)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNAi depletion of Tmod1 from either wild-type or Tmod4(-/-) muscle fibers leads to thin filament elongation by approximately 15%.
Title: Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.
Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle.
Title: Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle.
Tmod4 localizes to thin filament pointed ends in Tmod1-null embryonic muscle
Title: Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224784

RH135488 (e-PCR)
- UniSTS:164702

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle thin filament	IDA Inferred from Direct Assay more info	PubMed
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tropomodulin-4

Names: skeletal muscle tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428789.1 → NP_001415718.1 tropomodulin-4

Status: VALIDATED

Source sequence(s)

AC131769
NM_001428790.1 → NP_001415719.1 tropomodulin-4

Status: VALIDATED

Source sequence(s)

AC131769
NM_016712.5 → NP_057921.1 tropomodulin-4

See identical proteins and their annotated locations for NP_057921.1

Status: VALIDATED

Source sequence(s)

AC131769

Consensus CDS

CCDS17601.1

UniProtKB/Swiss-Prot

Q9JLH8

UniProtKB/TrEMBL

Q3UN19

Related

ENSMUSP00000005769.7, ENSMUST00000005769.13

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

95030110..95036520

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319636.1 → XP_017175125.1 tropomodulin-4 isoform X1

UniProtKB/Swiss-Prot

Q9JLH8

UniProtKB/TrEMBL

Q3UN19

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_030252671.2 → XP_030108531.1 tropomodulin-4 isoform X1

UniProtKB/Swiss-Prot

Q9JLH8

UniProtKB/TrEMBL

Q3UN19

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_030252672.2 → XP_030108532.1 tropomodulin-4 isoform X1

UniProtKB/Swiss-Prot

Q9JLH8

UniProtKB/TrEMBL

Q3UN19

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_030252670.2 → XP_030108530.1 tropomodulin-4 isoform X1

UniProtKB/Swiss-Prot

Q9JLH8

UniProtKB/TrEMBL

Q3UN19

Related

ENSMUSP00000102846.2, ENSMUST00000107227.4

Conserved Domains (2) summary

pfam03250
Location:4 → 143

Tropomodulin

cl39015
Location:184 → 286

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...