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Capn15 calpain 15 [ Mus musculus (house mouse) ]

Gene ID: 50817, updated on 11-Apr-2024

Summary

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Official Symbol
Capn15provided by MGI
Official Full Name
calpain 15provided by MGI
Primary source
MGI:MGI:1355075
See related
Ensembl:ENSMUSG00000037326 AllianceGenome:MGI:1355075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Solh
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in brain; genitourinary system; and retina ganglion cell layer. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 32.7), ovary adult (RPKM 26.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Capn15 in Genome Data Viewer
Location:
17 A3.3; 17 13.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26177338..26204753, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25958364..25985874, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene RIKEN cDNA gene D630044L22 gene Neighboring gene NHL repeat containing 4 Neighboring gene proline rich 35 Neighboring gene RIKEN cDNA 1700022N22 gene Neighboring gene RAB11 family interacting protein 3 (class II) Neighboring gene STARR-positive B cell enhancer ABC_E1937 Neighboring gene STARR-seq mESC enhancer starr_42116 Neighboring gene membrane-associated ring finger (C3HC4) 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MRI of Capn15 Knockout Mice and Analysis of Capn 15 Distribution Reveal Possible Roles in Brain Development and Plasticity. Zha C, et al. Neuroscience, 2021 Jun 15. PMID 33951504
  2. Solh, the mouse homologue of the Drosophila melanogaster small optic lobes gene: organization, chromosomal mapping, and localization of gene product to the olfactory bulb. Kamei M, et al. Genomics, 2000 Feb 15. PMID 10708520
  3. Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits. Zha C, et al. Hum Mol Genet, 2020 Nov 4. PMID 32885237, Free PMC Article
  4. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel association of Dandy-Walker malformation with CAPN15 variants expands the phenotype of oculogastrointestinal neurodevelopmental syndrome.
    Title: Novel association of Dandy-Walker malformation with CAPN15 variants expands the phenotype of oculogastrointestinal neurodevelopmental syndrome.
  2. Behavioral characterization of Capn15 conditional knockout mice.
    Title: Behavioral characterization of Capn15 conditional knockout mice.
  3. Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.
    Title: Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calpain-15
Names
small optic lobes homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347334.2 → NP_001334263.1  calpain-15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS84286.1
    UniProtKB/Swiss-Prot
    Q6PEE9, Q9JLG8
    UniProtKB/TrEMBL
    A0A1D5RLS3
    Related
    ENSMUSP00000148486.2, ENSMUST00000212520.2

  2. NM_001413962.1 → NP_001400891.1  calpain-15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159277

  3. NM_001413963.1 → NP_001400892.1  calpain-15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Related
    ENSMUSP00000039528.9, ENSMUST00000041641.9

  4. NM_001413964.1 → NP_001400893.1  calpain-15 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC159277

  5. NM_001413965.1 → NP_001400894.1  calpain-15 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC159277

  6. NM_015830.3 → NP_056645.2  calpain-15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS28540.1

RNA

  1. NR_151779.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Related
    ENSMUST00000212789.2

  2. NR_182225.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277

  3. NR_182226.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159277

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26177338..26204753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524605.4 → XP_006524668.1  calpain-15 isoform X1

    UniProtKB/Swiss-Prot
    Q6PEE9, Q9JLG8
    Conserved Domains (4) summary
    smart00547
    Location:490 → 514
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:552 → 847
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:457 → 472
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:420 → 439
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  2. XM_006524609.5 → XP_006524672.1  calpain-15 isoform X4

    UniProtKB/Swiss-Prot
    Q6PEE9, Q9JLG8
    Related
    ENSMUSP00000148718.2, ENSMUST00000212149.2
    Conserved Domains (4) summary
    smart00547
    Location:424 → 448
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:486 → 801
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:391 → 406
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:354 → 373
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RNA

  1. XR_003952148.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLG8.1 GenPept UniProtKB/Swiss-Prot:Q9JLG8

Gene LinkOut

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