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COPS7A COP9 signalosome subunit 7A [ Homo sapiens (human) ]

Gene ID: 50813, updated on 7-Apr-2024

Summary

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Official Symbol
COPS7Aprovided by HGNC
Official Full Name
COP9 signalosome subunit 7Aprovided by HGNC
Primary source
HGNC:HGNC:16758
See related
Ensembl:ENSG00000111652 MIM:616009; AllianceGenome:HGNC:16758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN7; CSN7A; SGN7a
Summary
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in brain (RPKM 27.2), thyroid (RPKM 23.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6724046..6731865)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6734396..6742219)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6833212..6841031)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6808761-6809262 Neighboring gene PILR alpha associated neural protein Neighboring gene RNA, U6 small nuclear 781, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5880 Neighboring gene myeloid leukemia factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4181 Neighboring gene parathymosin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA KRT19P3 suppresses proliferation and metastasis through COPS7A-mediated NF-κB pathway in gastric cancer. Zheng J, et al. Oncogene, 2019 Nov. PMID 31409899
  2. Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines. De Kegel B, et al. Cell Syst, 2021 Dec 15. PMID 34529928
  3. Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. Wang Y, et al. Biochem J, 2002 Aug 15. PMID 12020345, Free PMC Article
  4. The organization of a CSN5-containing subcomplex of the COP9 signalosome. Kotiguda GG, et al. J Biol Chem, 2012 Dec 7. PMID 23086934, Free PMC Article
  5. The COP9 signalosome: more than a protease. Wei N, et al. Trends Biochem Sci, 2008 Dec. PMID 18926707

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC110877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deneddylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein neddylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of protein neddylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
COP9 signalosome complex subunit 7a
Names
COP9 complex subunit 7a
COP9 constitutive photomorphogenic homolog subunit 7A
JAB1-containing signalosome subunit 7a
dermal papilla-derived protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034023.1 RefSeqGene

    Range
    5063..12882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164093.2 → NP_001157565.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK292621, BC011789, BQ008460, DC355036
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    A8K9A6, Q9NVX3, Q9UBW8, Q9UJW4
    UniProtKB/TrEMBL
    Q567U8
    Related
    ENSP00000446039.1, ENST00000534947.5
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  2. NM_001164094.2 → NP_001157566.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC011789, BQ008460, DA043679
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    A8K9A6, Q9NVX3, Q9UBW8, Q9UJW4
    UniProtKB/TrEMBL
    Q567U8
    Related
    ENSP00000438115.1, ENST00000543155.6
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  3. NM_001164095.3 → NP_001157567.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AB014764, AC125494, BC011789, BQ008460, HY087807
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    A8K9A6, Q9NVX3, Q9UBW8, Q9UJW4
    UniProtKB/TrEMBL
    Q567U8
    Related
    ENSP00000441852.1, ENST00000539735.5
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  4. NM_016319.4 → NP_057403.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_057403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC125494, AF210052, BC011789, BQ008460
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    A8K9A6, Q9NVX3, Q9UBW8, Q9UJW4
    UniProtKB/TrEMBL
    Q567U8
    Related
    ENSP00000229251.3, ENST00000229251.7
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6724046..6731865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253694.3 → XP_005253751.1  COP9 signalosome complex subunit 7a isoform X1

    See identical proteins and their annotated locations for XP_005253751.1

    UniProtKB/Swiss-Prot
    A8K9A6, Q9NVX3, Q9UBW8, Q9UJW4
    UniProtKB/TrEMBL
    Q567U8
    Related
    ENSP00000438363.1, ENST00000534877.5
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6734396..6742219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372155.1 → XP_054228130.1  COP9 signalosome complex subunit 7a isoform X1

    UniProtKB/Swiss-Prot
    A8K9A6, Q9NVX3, Q9UBW8, Q9UJW4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UBW8.1 GenPept UniProtKB/Swiss-Prot:Q9UBW8

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