Dmrt1 doublesex and mab-3 related transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmrt1provided by MGI
Official Full Name: doublesex and mab-3 related transcription factor 1provided by MGI
Primary source: MGI:MGI:1354733
See related: Ensembl:ENSMUSG00000024837 AllianceGenome:MGI:1354733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including male germ cell proliferation; regulation of nuclear division; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including gamete generation; positive regulation of male gonad development; and positive regulation of meiosis I. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; gonad; gonad primordium; and mesonephros. Orthologous to human DMRT1 (doublesex and mab-3 related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 2.8) See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 20.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (25483070..25581692)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (25505618..25604328)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor Dmrt1 triggers the SPRY1-NF-kappaB pathway to maintain testicular immune homeostasis and male fertility.
Title: Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility.
DMRT1: An Ancient Sexual Regulator Required for Human Gonadogenesis.
Title: DMRT1: An Ancient Sexual Regulator Required for Human Gonadogenesis.
DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency.
Title: DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency.
Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells.
Title: Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells.
Only rare DMRT1+ cells were detected in the adult rete testis, whereas more than 40% of cells were positively stained for DMRT1 in the immature rete testis.
Title: The rete testis harbors Sertoli-like cells capable of expressing DMRT1.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9, together with Sox8 and coordinately with Dmrt1, also controls adult testis maintenance.
Title: Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration.
miR-224 overexpression increases the expression of GFRalpha1 and PLZF, accompanied by the down-regulation of DMRT1 in mouse testes.
Title: MicroRNA-224 regulates self-renewal of mouse spermatogonial stem cells via targeting DMRT1.
Dmrt1 supports spermatogonial stem cell pool homeostasis.
Title: DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment.
DMRT1 expression in the ovary silenced the female sex-maintenance gene Foxl2 and reprogrammed juvenile and adult granulosa cells into Sertoli-like cells, triggering formation of structures resembling male seminiferous tubules.
Title: Sexual cell-fate reprogramming in the ovary by DMRT1.
Enforced expression of Dmrt1 in XX mouse fetal gonads using a Wt1-BAC transgene system is sufficient to drive testicular differentiation and male secondary sex development.
Title: Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:464667

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:516702

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:516703

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:516704

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:516705

NoName (e-PCR)
- UniSTS:492262

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Sertoli cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Sertoli cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental process involved in reproduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in male germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of nodal signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.