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Klf13 Kruppel-like transcription factor 13 [ Mus musculus (house mouse) ]

Gene ID: 50794, updated on 8-May-2024

Summary

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Official Symbol
Klf13provided by MGI
Official Full Name
Kruppel-like transcription factor 13provided by MGI
Primary source
MGI:MGI:1354948
See related
Ensembl:ENSMUSG00000052040 AllianceGenome:MGI:1354948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bteb3; FKLF2; NSLP1; FKLF-2; RFLAT1; RFLAT-1; 0610043C13Rik; 9430029L20Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation and negative regulation of erythrocyte differentiation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and neural retina. Orthologous to human KLF13 (Kruppel like factor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 63.8), lung adult (RPKM 36.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 C; 7 34.58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (63536099..63588663, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (63886351..63938915, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39023 Neighboring gene uncharacterized protein C9orf85 homolog pseudogene Neighboring gene predicted gene, 32345 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71042066-71042379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71046389-71046617 Neighboring gene predicted gene 27252 Neighboring gene predicted gene, 53391 Neighboring gene RIKEN cDNA E030018B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E3721 Neighboring gene STARR-seq mESC enhancer starr_19020 Neighboring gene STARR-positive B cell enhancer ABC_E4930 Neighboring gene STARR-seq mESC enhancer starr_19022 Neighboring gene predicted gene, 39024 Neighboring gene predicted gene, 51514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis. Yang S, et al. Cell Rep, 2023 Apr 25. PMID 37029927
  2. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis. Zeng N, et al. Int J Exp Pathol, 2023 Feb. PMID 36583453, Free PMC Article
  3. The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Krüppel-like factor 9 in the peri-implantation uterus. Heard ME, et al. Biol Reprod, 2012 Nov. PMID 22993382, Free PMC Article
  4. KLF13 influences multiple stages of both B and T cell development. Outram SV, et al. Cell Cycle, 2008 Jul 1. PMID 18604172
  5. Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo. Zhou M, et al. J Immunol, 2007 May 1. PMID 17442931, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis.
    Title: KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis.
  2. KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
    Title: KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
  3. The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
    Title: The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
  4. the improvement of cardiac function and structure elicited by miR-125b-5p is in part attributed to repression of the pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes.
    Title: A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
  5. Methylation levels at cg07814318 also positively correlated with ghrelin levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice
    Title: A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
  6. These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
    Title: Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
  7. The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.
    Title: KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
  8. Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis.
    Title: Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.
  9. KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.
    Title: KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.
  10. Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
    Title: Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Krueppel-like factor 13
Names
BTE-binding protein 3
C2-H2 zinc finger protein
Kruppel-like factor 13
RANTES factor of late activated T-lymphocytes 1
basic transcription element-binding protein 3
erythroid transcription factor FKLF-2
transcription factor BTEB3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021366.3 → NP_067341.2  Krueppel-like factor 13

    See identical proteins and their annotated locations for NP_067341.2

    Status: VALIDATED

    Source sequence(s)
    AC127344, AC148977
    Consensus CDS
    CCDS21331.1
    UniProtKB/Swiss-Prot
    Q9ESX3, Q9JHF8, Q9JJZ6
    UniProtKB/TrEMBL
    Q3U2G6
    Related
    ENSMUSP00000067680.8, ENSMUST00000063694.10
    Conserved Domains (2) summary
    COG5048
    Location:163 → 253
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:170 → 192
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    63536099..63588663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJZ6.2 GenPept UniProtKB/Swiss-Prot:Q9JJZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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