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Acsl4 acyl-CoA synthetase long-chain family member 4 [ Mus musculus (house mouse) ]

Gene ID: 50790, updated on 11-Apr-2024

Summary

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Official Symbol
Acsl4provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 4provided by MGI
Primary source
MGI:MGI:1354713
See related
Ensembl:ENSMUSG00000031278 AllianceGenome:MGI:1354713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACS4; Facl4; Lacs4; 9430020A05Rik
Summary
Enables long-chain fatty acid-CoA ligase activity. Acts upstream of or within embryonic process involved in female pregnancy and neuron differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; limb mesenchyme; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 12.0), adrenal adult (RPKM 11.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F2; X 63.12 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141100989..141173792, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142317993..142390802, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5 Neighboring gene STARR-seq mESC enhancer starr_48018 Neighboring gene peptidylprolyl isomerase A pseudogene x_1100.1 Neighboring gene ribosomal protein L38 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease. Wang Y, et al. Int J Chron Obstruct Pulmon Dis, 2023. PMID 36817367, Free PMC Article
  2. ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression. Grube J, et al. Cell Death Dis, 2022 Aug 13. PMID 35963845, Free PMC Article
  3. ACSL4 contributes to ferroptosis-mediated rhabdomyolysis in exertional heat stroke. He S, et al. J Cachexia Sarcopenia Muscle, 2022 Jun. PMID 35243801, Free PMC Article
  4. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. Wang Y, et al. Redox Biol, 2022 May. PMID 35180475, Free PMC Article
  5. ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Cui Y, et al. Brain Behav Immun, 2021 Mar. PMID 33444733

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4.
    Title: Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4.
  2. METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1.
    Title: METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1.
  3. Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4-mediated ferroptosis.
    Title: Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4-mediated ferroptosis.
  4. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
  5. Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
    Title: Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
  6. ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model.
    Title: ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model.
  7. microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis.
    Title: microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis.
  8. Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury.
    Title: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury.
  9. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.
    Title: Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.
  10. Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease.
    Title: Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 4
Names
LACS 4
arachidonate--CoA ligase
fatty acid-Coenzyme A ligase, long chain 4
long-chain acyl-CoA synthetase 4
mACS4
NP_001028772.1
NP_062350.3
NP_997508.1
XP_011246144.1
XP_011246145.1
XP_030107239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033600.1 → NP_001028772.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

    See identical proteins and their annotated locations for NP_001028772.1

    Status: VALIDATED

    Source sequence(s)
    AL731672, BC016416
    Consensus CDS
    CCDS41156.1
    UniProtKB/TrEMBL
    Q8BW44, Q91YN3
    Related
    ENSMUSP00000108524.2, ENSMUST00000112903.8
    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  2. NM_019477.3 → NP_062350.3  long-chain-fatty-acid--CoA ligase 4 isoform 2

    See identical proteins and their annotated locations for NP_062350.3

    Status: VALIDATED

    Source sequence(s)
    AK054387, AL731672
    Consensus CDS
    CCDS41156.1
    UniProtKB/TrEMBL
    Q8BW44, Q91YN3
    Related
    ENSMUSP00000108525.2, ENSMUST00000112904.8
    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  3. NM_207625.2 → NP_997508.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

    See identical proteins and their annotated locations for NP_997508.1

    Status: VALIDATED

    Source sequence(s)
    AB033886, AL731672, BB857663
    Consensus CDS
    CCDS30448.1
    UniProtKB/Swiss-Prot
    Q5D071, Q9JHT4, Q9QUJ7, Q9R0H3
    UniProtKB/TrEMBL
    Q8BW44
    Related
    ENSMUSP00000033634.5, ENSMUST00000033634.5
    Conserved Domains (1) summary
    cd17639
    Location:121 → 696
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    141100989..141173792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251379.2 → XP_030107239.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5D071, Q9JHT4, Q9QUJ7, Q9R0H3
    UniProtKB/TrEMBL
    Q8BW44
    Conserved Domains (1) summary
    cd17639
    Location:121 → 696
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  2. XM_011247843.4 → XP_011246145.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

    See identical proteins and their annotated locations for XP_011246145.1

    UniProtKB/TrEMBL
    Q8BW44, Q91YN3
    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  3. XM_011247842.4 → XP_011246144.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

    See identical proteins and their annotated locations for XP_011246144.1

    UniProtKB/TrEMBL
    Q8BW44, Q91YN3
    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUJ7.2 GenPept UniProtKB/Swiss-Prot:Q9QUJ7

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