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Plpp2 phospholipid phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 50784, updated on 5-Mar-2024

Summary

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Official Symbol
Plpp2provided by MGI
Official Full Name
phospholipid phosphatase 2provided by MGI
Primary source
MGI:MGI:1354945
See related
Ensembl:ENSMUSG00000052151 AllianceGenome:MGI:1354945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lpp2; PAP2c; PAP2-G; Ppap2c; PAP2-gamma
Summary
The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Broad expression in large intestine adult (RPKM 123.4), small intestine adult (RPKM 120.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79362258..79369621, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79526424..79533787, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 82 Neighboring gene STARR-seq mESC enhancer starr_27245 Neighboring gene vomeronasal 2, receptor 83 Neighboring gene STARR-seq mESC enhancer starr_27246 Neighboring gene STARR-seq mESC enhancer starr_27247 Neighboring gene microRNA 6909 Neighboring gene MIER family member 2 Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Zhang N, et al. Genesis, 2000 Aug. PMID 10992322
  2. Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases. Zhang N, et al. Genomics, 2000 Jan 1. PMID 10662554
  3. The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Escalante-Alcalde D, et al. Development, 2003 Oct. PMID 12925589
  4. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, et al. Glia, 2011 Apr. PMID 21319224, Free PMC Article
  5. The in vivo brain interactome of the amyloid precursor protein. Bai Y, et al. Mol Cell Proteomics, 2008 Jan. PMID 17934213

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sphingosine-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid phosphatase 2
Names
lipid phosphate phosphohydrolase 2
phosphatidate phosphohydrolase type 2c
phosphatidic acid phosphatase 2c
phosphatidic acid phosphatase type 2C
NP_001289318.1
NP_001289319.1
NP_001289371.1
NP_056632.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302389.1 → NP_001289318.1  phospholipid phosphatase 2 isoform 2

    See identical proteins and their annotated locations for NP_001289318.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Both variants 2 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AK005452, AK049581, BB737982, BB868752, CA540403
    Consensus CDS
    CCDS78849.1
    UniProtKB/TrEMBL
    G3XA61
    Related
    ENSMUST00000163602.9
    Conserved Domains (1) summary
    cd03384
    Location:38 → 183
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_001302390.1 → NP_001289319.1  phospholipid phosphatase 2 isoform 3

    See identical proteins and their annotated locations for NP_001289319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC100708, AK005452, AK049581, BB737982, BB868752, BQ571983
    Consensus CDS
    CCDS88047.1
    UniProtKB/TrEMBL
    A0A1W2P7I9
    Related
    ENSMUSP00000151683.2, ENSMUST00000218241.2
    Conserved Domains (1) summary
    cd03384
    Location:1 → 121
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  3. NM_001302442.1 → NP_001289371.1  phospholipid phosphatase 2 isoform 2

    See identical proteins and their annotated locations for NP_001289371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Both variants 2 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AK049581, BB737982, BB868752
    Consensus CDS
    CCDS78849.1
    UniProtKB/TrEMBL
    G3XA61
    Related
    ENSMUSP00000133247.2, ENSMUST00000166804.2
    Conserved Domains (1) summary
    cd03384
    Location:38 → 183
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  4. NM_015817.3 → NP_056632.2  phospholipid phosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_056632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK049581, BB737982, BB868752
    Consensus CDS
    CCDS35966.1
    UniProtKB/Swiss-Prot
    Q9DAX2, Q9WUA4
    UniProtKB/TrEMBL
    Q5U4G4
    Related
    ENSMUSP00000069670.6, ENSMUST00000063879.13
    Conserved Domains (1) summary
    cd03384
    Location:94 → 239
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79362258..79369621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAX2.1 GenPept UniProtKB/Swiss-Prot:Q9DAX2

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