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Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Mus musculus (house mouse) ]

Gene ID: 50781, updated on 5-Mar-2024

Summary

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Official Symbol
Dkk3provided by MGI
Official Full Name
dickkopf WNT signaling pathway inhibitor 3provided by MGI
Primary source
MGI:MGI:1354952
See related
Ensembl:ENSMUSG00000030772 AllianceGenome:MGI:1354952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dkk-3; mDkk-3
Summary
Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cellular biosynthetic process. Predicted to act upstream of or within Wnt signaling pathway. Located in extracellular space. Is expressed in several structures, including brain; cardiovascular system; eye; limb; and tooth. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 37.0), bladder adult (RPKM 29.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F1; 7 58.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (111715226..111758689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (112116019..112159482, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3960 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene STARR-positive B cell enhancer ABC_E10463 Neighboring gene STARR-seq mESC enhancer starr_19852 Neighboring gene STARR-positive B cell enhancer ABC_E6587 Neighboring gene predicted gene, 39071 Neighboring gene predicted gene, 39070

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration. Arnold F, et al. Adv Sci (Weinh), 2021 Jul. PMID 34306986, Free PMC Article
  2. Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland. Fujita H, et al. Acta Med Okayama, 2020 Jun. PMID 32577017
  3. DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage. Xu Y, et al. J Neuroinflammation, 2020 Apr 24. PMID 32331523, Free PMC Article
  4. Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse. Song KM, et al. Andrology, 2020 Sep. PMID 32170840
  5. Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla. Habuta M, et al. Cell Tissue Res, 2020 Jan. PMID 31673758

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
    Title: Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
  2. A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
    Title: A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
  3. Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
    Title: Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
  4. Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
    Title: Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
  5. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
    Title: Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
  6. Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
    Title: Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
  7. Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
    Title: Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
  8. DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
    Title: DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
  9. Dkk3 maintains the integrity of secreting vesicles in mouse adrenal medulla by regulating the expression of chromogranin A and neuropeptide Y
    Title: Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla.
  10. Dkk3 binds to CXCR7 and enhances vascular progenitor cells cell migration and vascular regeneration.
    Title: Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
dickkopf-related protein 3
Names
dickkopf homolog 3
dickkopf-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360257.1 → NP_001347186.1  dickkopf-related protein 3 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC122343, FO707532

  2. NM_001360260.1 → NP_001347189.1  dickkopf-related protein 3 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC122343, AC166834
    Consensus CDS
    CCDS21752.1
    UniProtKB/Swiss-Prot
    Q9QUN9
    Conserved Domains (1) summary
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  3. NM_001360261.1 → NP_001347190.1  dickkopf-related protein 3 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC122343, AC166834
    Conserved Domains (1) summary
    pfam04706
    Location:119 → 168
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  4. NM_015814.3 → NP_056629.1  dickkopf-related protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_056629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC166834, AK004853
    Consensus CDS
    CCDS21752.1
    UniProtKB/Swiss-Prot
    Q9QUN9
    Related
    ENSMUSP00000033036.6, ENSMUST00000033036.7
    Conserved Domains (1) summary
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    111715226..111758689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUN9.1 GenPept UniProtKB/Swiss-Prot:Q9QUN9

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