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Fbxo15 F-box protein 15 [ Mus musculus (house mouse) ]

Gene ID: 50764, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxo15provided by MGI
Official Full Name
F-box protein 15provided by MGI
Primary source
MGI:MGI:1354755
See related
Ensembl:ENSMUSG00000034391 AllianceGenome:MGI:1354755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx15; ecat3
Summary
Predicted to contribute to ubiquitin protein ligase activity. Part of SCF ubiquitin ligase complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human FBXO15 (F-box protein 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.7) and placenta adult (RPKM 0.2) See more
Orthologs
human all
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Genomic context

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See Fbxo15 in Genome Data Viewer
Location:
18 E4; 18 57.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84952677..84999601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84934552..84981476)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45257 Neighboring gene STARR-positive B cell enhancer ABC_E8728 Neighboring gene predicted gene, 17266 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:85043680-85043998 Neighboring gene STARR-seq mESC enhancer starr_45258 Neighboring gene predicted gene 16146 Neighboring gene STARR-positive B cell enhancer ABC_E11009 Neighboring gene STARR-seq mESC enhancer starr_45265 Neighboring gene cytochrome b5 type A (microsomal) Neighboring gene STARR-seq mESC enhancer starr_45275 Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene STARR-seq mESC enhancer starr_45276 Neighboring gene STARR-seq mESC enhancer starr_45277 Neighboring gene STARR-seq mESC enhancer starr_45279 Neighboring gene predicted gene, 32291 Neighboring gene predicted gene 7612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15. Zhang Z, et al. Sci Rep, 2020 Nov 6. PMID 33159144, Free PMC Article
  2. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Donato V, et al. Nat Cell Biol, 2017 Apr. PMID 28319092, Free PMC Article
  3. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Chen BB, et al. Cell Rep, 2014 Apr 24. PMID 24703837, Free PMC Article
  4. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, et al. Mol Cell Biol, 2003 Apr. PMID 12665572, Free PMC Article
  5. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Han DW, et al. Cell, 2010 Nov 12. PMID 21056461

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15.
    Title: Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15.
  2. TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
    Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
  3. Fbxo15 mediates degradation of cardiolipin synthase1 in pneumonia.
    Title: E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia.
  4. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal, development, and fertility.
    Title: Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin protein ligase activity IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367965.1 → NP_001354894.1  F-box only protein 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128672, AC134545
    Consensus CDS
    CCDS89296.1
    UniProtKB/Swiss-Prot
    Q9QZN0
    UniProtKB/TrEMBL
    A0A494BAM1
    Related
    ENSMUSP00000158102.2, ENSMUST00000223789.3

  2. NM_015798.5 → NP_056613.2  F-box only protein 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK166591, AK167270
    Consensus CDS
    CCDS37877.2
    UniProtKB/Swiss-Prot
    Q9QZN0
    UniProtKB/TrEMBL
    A0A286YDM4
    Related
    ENSMUSP00000153473.2, ENSMUST00000224467.3
    Conserved Domains (1) summary
    pfam12937
    Location:2 → 42
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84952677..84999601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247086.1 → XP_011245388.1  F-box only protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011245388.1

    UniProtKB/Swiss-Prot
    Q9QZN0
    UniProtKB/TrEMBL
    Q3TJW2
    Related
    ENSMUSP00000045925.10, ENSMUST00000037718.10
    Conserved Domains (1) summary
    pfam12937
    Location:43 → 87
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZN0.2 GenPept UniProtKB/Swiss-Prot:Q9QZN0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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