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Fbxo6 F-box protein 6 [ Mus musculus (house mouse) ]

Gene ID: 50762, updated on 11-Apr-2024

Summary

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Official Symbol
Fbxo6provided by MGI
Official Full Name
F-box protein 6provided by MGI
Primary source
MGI:MGI:1354743
See related
Ensembl:ENSMUSG00000055401 AllianceGenome:MGI:1354743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBG2; Fbs2; Fbx6b; Fbxo6b
Summary
Enables carbohydrate binding activity. Contributes to ubiquitin protein ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and ubiquitin-dependent ERAD pathway. Acts upstream of or within glycoprotein catabolic process. Located in endoplasmic reticulum quality control compartment. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human FBXO6 (F-box protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 22.6), liver adult (RPKM 18.1) and 28 other tissues See more
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Genomic context

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Location:
4 E2; 4 78.67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148230173..148236592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148145716..148152135, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12067 Neighboring gene STARR-seq mESC enhancer starr_12068 Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147472153-147472360 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene MAD2 mitotic arrest deficient-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E4728 Neighboring gene microRNA 7022 Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2 Neighboring gene STARR-seq mESC enhancer starr_12077 Neighboring gene predicted gene, 32603

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival. Cen M, et al. J Med Virol, 2023 Jan. PMID 36217277, Free PMC Article
  2. Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Yoshida Y, et al. Proc Natl Acad Sci U S A, 2021 Jul 6. PMID 34215698, Free PMC Article
  3. Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene. Bliskovsky V, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14634209, Free PMC Article
  4. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. Yoshida Y, et al. J Biol Chem, 2003 Oct 31. PMID 12939278
  5. A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins. Shenkman M, et al. J Biol Chem, 2013 Jan 25. PMID 23233672, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
    Title: Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
  2. FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.
    Title: FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.
  3. Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
    Title: Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
  4. Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD
    Title: Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycoprotein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum quality control compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum quality control compartment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 6
Names
F-box only protein 6b
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163704.1 → NP_001157176.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_001157176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AK150612, AK165867, BB854497
    Consensus CDS
    CCDS18933.1
    UniProtKB/Swiss-Prot
    A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
    UniProtKB/TrEMBL
    Z4YN00
    Related
    ENSMUSP00000030858.8, ENSMUST00000030858.14
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 47
    F-box-like

  2. NM_001163705.1 → NP_001157177.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_001157177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AK165867, AK171483, BB854497, BY260050
    Consensus CDS
    CCDS18933.1
    UniProtKB/Swiss-Prot
    A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
    UniProtKB/TrEMBL
    Z4YN00
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 47
    F-box-like

  3. NM_001163706.1 → NP_001157178.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_001157178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AK165867, AK171483
    Consensus CDS
    CCDS18933.1
    UniProtKB/Swiss-Prot
    A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
    UniProtKB/TrEMBL
    Z4YN00
    Related
    ENSMUSP00000062348.6, ENSMUST00000056965.12
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 47
    F-box-like

  4. NM_001163707.1 → NP_001157179.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_001157179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AK165867, AK171483, BY164736
    Consensus CDS
    CCDS18933.1
    UniProtKB/Swiss-Prot
    A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
    UniProtKB/TrEMBL
    Z4YN00
    Related
    ENSMUSP00000130188.2, ENSMUST00000168503.8
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 47
    F-box-like

  5. NM_015797.4 → NP_056612.1  F-box only protein 6

    See identical proteins and their annotated locations for NP_056612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
    Source sequence(s)
    AK165867, BB854497
    Consensus CDS
    CCDS18933.1
    UniProtKB/Swiss-Prot
    A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
    UniProtKB/TrEMBL
    Z4YN00
    Related
    ENSMUSP00000101331.2, ENSMUST00000105706.8
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 47
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148230173..148236592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZN4.1 GenPept UniProtKB/Swiss-Prot:Q9QZN4

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