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Fbxo8 F-box protein 8 [ Mus musculus (house mouse) ]

Gene ID: 50753, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxo8provided by MGI
Official Full Name
F-box protein 8provided by MGI
Primary source
MGI:MGI:1354696
See related
Ensembl:ENSMUSG00000038206 AllianceGenome:MGI:1354696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx8
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ear; forelimb bud; heart; and notochord. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 8.5), kidney adult (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B2; 8 29.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57004189..57046974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (56551154..56593939)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930518J21 gene Neighboring gene STARR-seq mESC enhancer starr_21518 Neighboring gene predicted gene, 24375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:59029623-59029732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:59030027-59030210 Neighboring gene STARR-positive B cell enhancer mm9_chr8:59030212-59030513 Neighboring gene centrosomal protein 44 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21519 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21521 Neighboring gene VISTA enhancer mm1687 Neighboring gene predicted gene, 33501

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fbx8 makes Arf6 refractory to function via ubiquitination. Yano H, et al. Mol Biol Cell, 2008 Mar. PMID 18094045, Free PMC Article
  2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
  3. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
  4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fbx8, an F-box protein bearing the Sec7 domain, mediates ubiquitination of Arf6.
    Title: Fbx8 makes Arf6 refractory to function via ubiquitination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368347.1 → NP_001355276.1  F-box only protein 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116121
    Conserved Domains (1) summary
    cd00171
    Location:1 → 155
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

  2. NM_001368348.1 → NP_001355277.1  F-box only protein 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116121
    Conserved Domains (1) summary
    cd00171
    Location:1 → 155
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

  3. NM_015791.4 → NP_056606.2  F-box only protein 8 isoform 1

    See identical proteins and their annotated locations for NP_056606.2

    Status: VALIDATED

    Source sequence(s)
    AC116121
    Consensus CDS
    CCDS22314.1
    UniProtKB/Swiss-Prot
    Q8JZY7, Q9QZN3
    UniProtKB/TrEMBL
    Q8BP70
    Related
    ENSMUSP00000037544.6, ENSMUST00000040218.13
    Conserved Domains (2) summary
    cd00171
    Location:133 → 312
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    pfam12937
    Location:74 → 112
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    57004189..57046974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZN3.2 GenPept UniProtKB/Swiss-Prot:Q9QZN3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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