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Mfap5 microfibrillar associated protein 5 [ Mus musculus (house mouse) ]

Gene ID: 50530, updated on 5-Mar-2024

Summary

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Official Symbol
Mfap5provided by MGI
Official Full Name
microfibrillar associated protein 5provided by MGI
Primary source
MGI:MGI:1354387
See related
Ensembl:ENSMUSG00000030116 AllianceGenome:MGI:1354387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAGP-2; MFAP-5
Summary
Predicted to enable extracellular matrix constituent conferring elasticity. Involved in definitive hemopoiesis. Acts upstream of or within supramolecular fiber organization. Located in extracellular matrix. Is expressed in aorta; bladder; esophagus; male reproductive system; and skeletal musculature. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human MFAP5 (microfibril associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 54.4), mammary gland adult (RPKM 48.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F1; 6 57.61 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122490543..122506249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122513584..122529290)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17224 Neighboring gene ribosomal modification protein rimK-like family member B Neighboring gene ribosomal protein S27A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17225 Neighboring gene STARR-positive B cell enhancer ABC_E10409 Neighboring gene STARR-positive B cell enhancer ABC_E1070 Neighboring gene STARR-positive B cell enhancer ABC_E9100 Neighboring gene STARR-positive B cell enhancer mm9_chr6:122484210-122484511 Neighboring gene STARR-positive B cell enhancer ABC_E11336 Neighboring gene STARR-positive B cell enhancer ABC_E3677 Neighboring gene STARR-positive B cell enhancer ABC_E3678 Neighboring gene activation-induced cytidine deaminase Neighboring gene voltage-dependent anion channel 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Microfibril-associated protein 5 and the regulation of skin scar formation. Han C, et al. Sci Rep, 2023 May 30. PMID 37253753, Free PMC Article
  2. Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways. Li H, et al. Mol Med, 2021 Dec 5. PMID 34865619, Free PMC Article
  3. The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche. Mecham RP, et al. Matrix Biol, 2015 Sep. PMID 25963142, Free PMC Article
  4. Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage. Miyamoto A, et al. Matrix Biol, 2014 Nov. PMID 25153248
  5. Functional evolution of the microfibril-associated glycoproteins. Segade F. Gene, 2009 Jun 15. PMID 19332111

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
    Title: Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
  2. Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin alphavbeta3/PTK2/AKT Signaling.
    Title: Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling.
  3. Microfibril-associated protein 5 and the regulation of skin scar formation.
    Title: Microfibril-associated protein 5 and the regulation of skin scar formation.
  4. MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
    Title: MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
  5. Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/beta-catenin and AMPK signaling pathways.
    Title: Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways.
  6. Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
    Title: Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
  7. Loss of MAGP2 expression in vivo has pleiotropic effects.
    Title: Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.
  8. MAGP-2 is identified as a novel regulator of angiogenesis.
    Title: Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis.
  9. Tight skin fibrillin 1 altered extracellular matrix organization and caused fibrosis by affecting deposition of MAGP-2 or other fibrillin-1-associated proteins.
    Title: Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen.
  10. interaction with fibrillin-1 and fibrillin-2 suggesting role in elastic fiber assembly
    Title: Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix constituent conferring elasticity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables extracellular matrix constituent conferring elasticity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic eye morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within supramolecular fiber organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in microfibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microfibril TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
microfibrillar-associated protein 5
Names
microfibril-associated glycoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347434.1 → NP_001334363.1  microfibrillar-associated protein 5 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC155946
    Consensus CDS
    CCDS85155.1
    UniProtKB/TrEMBL
    D3Z4D7, F8WJ99
    Related
    ENSMUSP00000032210.9, ENSMUST00000032210.14

  2. NM_015776.3 → NP_056591.1  microfibrillar-associated protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_056591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC155946
    Consensus CDS
    CCDS20496.1
    UniProtKB/Swiss-Prot
    Q9QZJ6
    UniProtKB/TrEMBL
    D3Z4D7
    Related
    ENSMUSP00000122863.2, ENSMUST00000148517.8
    Conserved Domains (1) summary
    pfam05507
    Location:35 → 129
    MAGP; Microfibril-associated glycoprotein (MAGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122490543..122506249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZJ6.1 GenPept UniProtKB/Swiss-Prot:Q9QZJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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