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DPRX divergent-paired related homeobox [ Homo sapiens (human) ]

Gene ID: 503834, updated on 5-Mar-2024

Summary

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Official Symbol
DPRXprovided by HGNC
Official Full Name
divergent-paired related homeoboxprovided by HGNC
Primary source
HGNC:HGNC:32166
See related
Ensembl:ENSG00000204595 MIM:611165; AllianceGenome:HGNC:32166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See DPRX in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53601114..53637014)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56680646..56716531)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54135253..54140268)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 813 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54008197-54008422 Neighboring gene ribosomal protein L39 pseudogene 37 Neighboring gene vomeronasal 1 receptor 103 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54022978-54023752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54023753-54024526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54024527-54025300 Neighboring gene zinc finger protein 331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54041127-54041643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15071 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:54080110-54081309 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54097943-54098874 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54098875-54099804 Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54109319-54109846 Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54115011-54116004 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54116005-54116999 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54117000-54117993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54122202-54122702 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54140228-54140728 Neighboring gene RNA, 7SL, cytoplasmic 317, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54146969-54147762 Neighboring gene uncharacterized LOC107985342 Neighboring gene nuclear RNA export factor 3 pseudogene Neighboring gene RNA, U6 small nuclear 698, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. Booth HA, et al. Gene, 2007 Jan 31. PMID 17005330
  2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  3. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
divergent paired-related homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012728.2 → NP_001012746.1  divergent paired-related homeobox

    See identical proteins and their annotated locations for NP_001012746.1

    Status: VALIDATED

    Source sequence(s)
    AC011487
    Consensus CDS
    CCDS33103.1
    UniProtKB/Swiss-Prot
    A6NFQ7
    Related
    ENSP00000365838.1, ENST00000376650.2
    Conserved Domains (1) summary
    pfam00046
    Location:19 → 72
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53601114..53637014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438893.1 → XP_047294849.1  divergent paired-related homeobox isoform X1

    UniProtKB/Swiss-Prot
    A6NFQ7
    Related
    ENSP00000518423.1, ENST00000710707.1

  2. XM_011527011.4 → XP_011525313.1  divergent paired-related homeobox isoform X1

    See identical proteins and their annotated locations for XP_011525313.1

    UniProtKB/Swiss-Prot
    A6NFQ7
    Conserved Domains (1) summary
    pfam00046
    Location:19 → 72
    Homeobox; Homeobox domain

  3. XM_011527012.3 → XP_011525314.1  divergent paired-related homeobox isoform X1

    See identical proteins and their annotated locations for XP_011525314.1

    UniProtKB/Swiss-Prot
    A6NFQ7
    Conserved Domains (1) summary
    pfam00046
    Location:19 → 72
    Homeobox; Homeobox domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56680646..56716531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321126.1 → XP_054177101.1  divergent paired-related homeobox isoform X1

    UniProtKB/Swiss-Prot
    A6NFQ7

  2. XM_054321128.1 → XP_054177103.1  divergent paired-related homeobox isoform X1

    UniProtKB/Swiss-Prot
    A6NFQ7

  3. XM_054321127.1 → XP_054177102.1  divergent paired-related homeobox isoform X1

    UniProtKB/Swiss-Prot
    A6NFQ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NFQ7.1 GenPept UniProtKB/Swiss-Prot:A6NFQ7

Gene LinkOut

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