DUXAP9 double homeobox A pseudogene 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUXAP9provided by HGNC
Official Full Name: double homeobox A pseudogene 9provided by HGNC
Primary source: HGNC:HGNC:32188
See related: AllianceGenome:HGNC:32188
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SAN; LNMAT1; LINC01296
Summary: Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: 14q11.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (19062377..19107497)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (13375526..13420650)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (19880209..19925329, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis.
Title: LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis.
Long noncoding RNA LINC01296 regulates the cell proliferation, migration and invasion in neuroblastoma.
Title: Long noncoding RNA LINC01296 regulates the cell proliferation, migration and invasion in neuroblastoma.
Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B.
Title: Downregulation of LINC01296 suppresses non-small-cell lung cancer via targeting miR-143-3p/ATG2B.
Long non-coding RNA LINC01296 acts as a migration and invasion promoter in head and neck squamous cell carcinoma and predicts poor prognosis.
Title: Long non-coding RNA LINC01296 acts as a migration and invasion promoter in head and neck squamous cell carcinoma and predicts poor prognosis.
Long non-coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9.
Title: Long non-coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9.
The Effect of LINC01296 Expression in Patients with Cancer: A Systematic Review and Meta-Analysis.
Title: The Effect of LINC01296 Expression in Patients with Cancer: A Systematic Review and Meta-Analysis.
Long noncoding RNA Linc01296 promotes hepatocellular carcinoma development through regulation of the miR-26a/PTEN axis.
Title: Long noncoding RNA Linc01296 promotes hepatocellular carcinoma development through regulation of the miR-26a/PTEN axis.
Functional experiments showed that DUXAP8 and DUXAP9 enhanced but miR-29c-3p weakened growth of renal cell carcinoma
Title: Overexpressed pseudogenes, DUXAP8 and DUXAP9, promote growth of renal cell carcinoma and serve as unfavorable prognostic biomarkers.
Overexpression of LINC01296 was associated with the clinicopathological features and poor prognosis in human Solid Malignant Tumours and could serve as a prognostic predictor.
Title: Prognostic value of long non-coding RNA 01296 expression in human solid malignant tumours: a meta-analysis.
LNMAT1-induced upregulation of CCL2 recruits macrophages into the tumor, which promotes lymphatic metastasis via VEGF-C excretion.
Title: LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

Lymph Node Metastasis Associated Transcript 1
lncRNA-CTD903
long intergenic non-protein coding RNA 1296
senescence-associated noncoding RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_122111.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AL589182
NR_122112.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains four alternate internal exons and differs in the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AL589182