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Spase12 Spase 12-subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50096, updated on 4-Apr-2024

Summary

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Official Symbol
Spase12provided by FlyBase
Official Full Name
Spase 12-subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0040623
Locus tag
Dmel_CG11500
See related
AllianceGenome:FB:FBgn0040623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11500; CG31042; Dmel\CG11500; spase12
Summary
Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be part of signal peptidase complex. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
99B1-99B1; 3-99 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29490544..29491150, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25316266..25316872, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 99A Neighboring gene long non-coding RNA:CR44022 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene diedel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum. Guan J, et al. Arch Insect Biochem Physiol, 2018 Mar. PMID 29265467
  2. An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H. Barbosa S, et al. Traffic, 2013 Apr. PMID 23279168, Free PMC Article
  3. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
  4. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
  5. CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators. Johnson DM, et al. Traffic, 2020 Sep. PMID 32613751, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spase12 is an essential gene required for development and cell differentiation in the fruitfly.
    Title: Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spase 12-subunit
Names
CG11500-PA
Spase12-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29490544..29491150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176583.3 → NP_788760.1  spase 12-subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788760.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAL0
    UniProtKB/TrEMBL
    C6SUX5
    Related
    FBpp0084801
    Conserved Domains (1) summary
    pfam06645
    Location:8 → 76
    SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAL0.2 Q9VAL0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
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