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Xkr4 X-linked Kx blood group related 4 [ Mus musculus (house mouse) ]

Gene ID: 497097, updated on 5-Mar-2024

Summary

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Official Symbol
Xkr4provided by MGI
Official Full Name
X-linked Kx blood group related 4provided by MGI
Primary source
MGI:MGI:3528744
See related
Ensembl:ENSMUSG00000051951 AllianceGenome:MGI:3528744
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XRG4; Gm210; mKIAA1889
Summary
Enables phospholipid scramblase activity and protein homodimerization activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Orthologous to human XKR4 (XK related 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.4), frontal lobe adult (RPKM 2.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A1; 1 1.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (3269956..3741733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (3199733..3671948, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00001 Neighboring gene predicted gene, 26206 Neighboring gene STARR-seq mESC enhancer starr_00002 Neighboring gene STARR-seq mESC enhancer starr_00003 Neighboring gene coenzyme Q2 homolog, prenyltransferase pseudogene Neighboring gene predicted gene, 53491 Neighboring gene STARR-seq mESC enhancer starr_00004 Neighboring gene STARR-seq mESC enhancer starr_00005 Neighboring gene STARR-seq mESC enhancer starr_00007 Neighboring gene STARR-seq mESC enhancer starr_00008 Neighboring gene solute carrier family 35 member E3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00010 Neighboring gene predicted gene, 57489 Neighboring gene STARR-seq mESC enhancer starr_00012 Neighboring gene STARR-seq mESC enhancer starr_00013 Neighboring gene STARR-seq mESC enhancer starr_00014 Neighboring gene STARR-seq mESC enhancer starr_00015 Neighboring gene STARR-seq mESC enhancer starr_00016 Neighboring gene predicted gene, 27396 Neighboring gene STARR-seq mESC enhancer starr_00017 Neighboring gene STARR-seq mESC enhancer starr_00018 Neighboring gene STARR-seq mESC enhancer starr_00019 Neighboring gene STARR-seq mESC enhancer starr_00020 Neighboring gene STARR-seq mESC enhancer starr_00021 Neighboring gene STARR-seq mESC enhancer starr_00022 Neighboring gene STARR-seq mESC enhancer starr_00023 Neighboring gene STARR-seq mESC enhancer starr_00024 Neighboring gene STARR-seq mESC enhancer starr_00025 Neighboring gene STARR-seq mESC enhancer starr_00026 Neighboring gene STARR-seq mESC enhancer starr_00027 Neighboring gene STARR-seq mESC enhancer starr_00028 Neighboring gene STARR-seq mESC enhancer starr_00029 Neighboring gene retinitis pigmentosa 1 (human) Neighboring gene actinin alpha 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. Maruoka M, et al. Mol Cell, 2021 Apr 1. PMID 33725486
  2. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
  3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
    Title: Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
  2. Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific.
    Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1889

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
XK-related protein 4
Names
X Kell blood group precursor related family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011874.1 → NP_001011874.1  XK-related protein 4

    See identical proteins and their annotated locations for NP_001011874.1

    Status: PROVISIONAL

    Source sequence(s)
    AY534250
    Consensus CDS
    CCDS14803.1
    UniProtKB/Swiss-Prot
    Q5GH67
    Related
    ENSMUSP00000070648.5, ENSMUST00000070533.5
    Conserved Domains (1) summary
    pfam09815
    Location:115 → 513
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    3269956..3741733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495550.5 → XP_006495613.1  XK-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006495613.1

    UniProtKB/Swiss-Prot
    Q5GH67
    Conserved Domains (1) summary
    pfam09815
    Location:115 → 513
    XK-related; XK-related protein

  2. XM_011238395.4 → XP_011236697.1  XK-related protein 4 isoform X3

    Conserved Domains (1) summary
    pfam09815
    Location:115 → 331
    XK-related; XK-related protein

  3. XM_036152287.1 → XP_036008180.1  XK-related protein 4 isoform X2

    Conserved Domains (1) summary
    pfam09815
    Location:111 → 327
    XK-related; XK-related protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5GH67.1 GenPept UniProtKB/Swiss-Prot:Q5GH67

Gene LinkOut

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