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Apcdd1 adenomatosis polyposis coli down-regulated 1 [ Mus musculus (house mouse) ]

Gene ID: 494504, updated on 5-Mar-2024

Summary

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Official Symbol
Apcdd1provided by MGI
Official Full Name
adenomatosis polyposis coli down-regulated 1provided by MGI
Primary source
MGI:MGI:3513977
See related
Ensembl:ENSMUSG00000071847 AllianceGenome:MGI:3513977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drapc1; EIG180
Summary
Predicted to enable Wnt-protein binding activity and identical protein binding activity. Involved in regulation of odontogenesis of dentin-containing tooth. Acts upstream of or within astrocyte cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; ear; and reproductive system. Human ortholog(s) of this gene implicated in hypotrichosis 1. Orthologous to human APCDD1 (APC down-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 94.0), limb E14.5 (RPKM 52.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 35.95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63055398..63086886)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62922327..62953815)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598 Neighboring gene STARR-seq mESC enhancer starr_44779 Neighboring gene STARR-seq mESC enhancer starr_44780 Neighboring gene predicted gene, 41752 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene piezo-type mechanosensitive ion channel component 2 Neighboring gene predicted gene, 36651

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Mazzoni J, et al. Neuron, 2017 Dec 6. PMID 29154126, Free PMC Article
  2. Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation. Biswas S, et al. Development, 2022 Sep 1. PMID 36098369, Free PMC Article
  3. A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity. Yiew NKH, et al. J Biol Chem, 2017 Apr 14. PMID 28242765, Free PMC Article
  4. The role of APCDD1 in epithelial rearrangement in tooth morphogenesis. Neupane S, et al. Histochem Cell Biol, 2015 Oct. PMID 26170146
  5. Transposition-based method for the rapid generation of gene-targeting vectors to produce Cre/Flp-modifiable conditional knock-out mice. Turakainen H, et al. PLoS One, 2009. PMID 19194496, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these novel findings suggest that APCDD1 positively regulates adipogenic differentiation and that its down-regulation by miR-130 during diet-induced obesity may contribute to impaired adipogenic differentiation and obesity-related metabolic disease.
    Title: A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  2. Suggest that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating epithelial rearrangement.
    Title: The role of APCDD1 in epithelial rearrangement in tooth morphogenesis.
  3. mouse Drapc1 is a novel in vivo target gene of Wnt/beta-catenin signaling pathway
    Title: Drapc1 expression during mouse embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within astrocyte cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein APCDD1
Names
adenomatosis polyposis coli down-regulated 1 protein homolog
ethanol induced gene product EIG180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133237.4 → NP_573500.2  protein APCDD1 precursor

    See identical proteins and their annotated locations for NP_573500.2

    Status: VALIDATED

    Source sequence(s)
    AC130204
    Consensus CDS
    CCDS37843.1
    UniProtKB/Swiss-Prot
    B2RUN4, Q3TA99, Q3U128
    Related
    ENSMUSP00000157539.2, ENSMUST00000236135.2
    Conserved Domains (1) summary
    pfam14921
    Location:51 → 282
    APCDDC; Adenomatosis polyposis coli down-regulated 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    63055398..63086886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161200.1 → XP_036017093.1  protein APCDD1 isoform X1

    Conserved Domains (1) summary
    pfam14921
    Location:1 → 192
    APCDDC; Adenomatosis polyposis coli down-regulated 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U128.1 GenPept UniProtKB/Swiss-Prot:Q3U128

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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