U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens (human) ]

Gene ID: 4926, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
NUMA1provided by HGNC
Official Full Name
nuclear mitotic apparatus protein 1provided by HGNC
Primary source
HGNC:HGNC:8059
See related
Ensembl:ENSG00000137497 MIM:164009; AllianceGenome:HGNC:8059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUMA; NMP-22
Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11q13.4
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72002864..72080542, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71929780..72007446, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71713910..71791588, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71660091-71661028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71661029-71661964 Neighboring gene ring finger protein 121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71725991-71726738 Neighboring gene uncharacterized LOC100128494 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:71728895-71730094 Neighboring gene interleukin 18 binding protein Neighboring gene Sharpr-MPRA regulatory region 3523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71751839-71752624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71752625-71753408 Neighboring gene uncharacterized LOC124902815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71790999-71791954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71791955-71792909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5180 Neighboring gene microRNA 3165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3713 Neighboring gene leucine rich repeat containing 51 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles. van Toorn M, et al. Curr Biol, 2023 Feb 6. PMID 36626904
  2. Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: A meta-analysis. Wang J, et al. Diagn Cytopathol, 2022 Jun. PMID 35322590, Free PMC Article
  3. NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation. Sun M, et al. Nat Commun, 2021 Dec 9. PMID 34887424, Free PMC Article
  4. Tissue Nuclear Matrix Protein Expression 22 in Various Grades and Stages of Bladder Cancer. Mati Q, et al. J Coll Physicians Surg Pak, 2020 Dec. PMID 33397061
  5. The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. Serra-Marques A, et al. J Cell Biol, 2020 Dec 7. PMID 33044554, Free PMC Article

See all (290) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles.
    Title: NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles.
  2. LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.
    Title: LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.
  3. Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
    Title: Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
  4. The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer.
    Title: The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer.
  5. Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: A meta-analysis.
    Title: Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: A meta-analysis.
  6. Mechanism of spindle pole organization and instability in human oocytes.
    Title: Mechanism of spindle pole organization and instability in human oocytes.
  7. NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation.
    Title: NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation.
  8. Nuclear IGF1R interacts with NuMA and regulates 53BP1dependent DNA doublestrand break repair in colorectal cancer.
    Title: Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer.
  9. Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.
    Title: Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.
  10. Tissue Nuclear Matrix Protein Expression 22 in Various Grades and Stages of Bladder Cancer.
    Title: Tissue Nuclear Matrix Protein Expression 22 in Various Grades and Stages of Bladder Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (79)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Acute promyelocytic leukemia
MedGen: C0023487 OMIM: 612376 GeneReviews: Not available
Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables disordered domain specific binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule minus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anastral spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in astral microtubule organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle orientation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hair follicle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cortical microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in lateral cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule minus-end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in spindle TAS
Traceable Author Statement
more info
 PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
nuclear mitotic apparatus protein 1
Names
SP-H antigen
centrophilin stabilizes mitotic spindle in mitotic cells
nuclear matrix protein-22
structural nuclear protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286561.2 → NP_001273490.1  nuclear mitotic apparatus protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001273490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB210007, BC004165, BG754891, BG771637, Z11583, Z11584
    Consensus CDS
    CCDS66156.1
    UniProtKB/TrEMBL
    Q4LE64
    Related
    ENSP00000351851.6, ENST00000358965.10
    Conserved Domains (2) summary
    TIGR02168
    Location:1015 → 1717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:254 → 1329
    Myosin_tail_1; Myosin tail

  2. NM_006185.4 → NP_006176.2  nuclear mitotic apparatus protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006176.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB210007, BC004165, BC027493, BG754891, BG771637
    Consensus CDS
    CCDS31633.1
    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9
    UniProtKB/TrEMBL
    Q4LE64
    Related
    ENSP00000377298.4, ENST00000393695.8
    Conserved Domains (2) summary
    cl25732
    Location:563 → 1331
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1746 → 2016
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RNA

  1. NR_104476.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
    Source sequence(s)
    AP002490, BC004165, BC103765, BG754891
    Related
    ENST00000351960.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    72002864..72080542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427023.1 → XP_047282979.1  nuclear mitotic apparatus protein 1 isoform X4

  2. XM_047427003.1 → XP_047282959.1  nuclear mitotic apparatus protein 1 isoform X2

  3. XM_047427016.1 → XP_047282972.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  4. XM_047426995.1 → XP_047282951.1  nuclear mitotic apparatus protein 1 isoform X1

  5. XM_017017830.2 → XP_016873319.1  nuclear mitotic apparatus protein 1 isoform X4

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    TIGR02168
    Location:1015 → 1717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:254 → 1329
    Myosin_tail_1; Myosin tail

  6. XM_047426997.1 → XP_047282953.1  nuclear mitotic apparatus protein 1 isoform X2

  7. XM_011545055.2 → XP_011543357.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543357.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  8. XM_047427019.1 → XP_047282975.1  nuclear mitotic apparatus protein 1 isoform X4

  9. XM_047426999.1 → XP_047282955.1  nuclear mitotic apparatus protein 1 isoform X2

  10. XM_047427008.1 → XP_047282964.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  11. XM_011545057.3 → XP_011543359.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543359.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  12. XM_047427026.1 → XP_047282982.1  nuclear mitotic apparatus protein 1 isoform X4

  13. XM_047427004.1 → XP_047282960.1  nuclear mitotic apparatus protein 1 isoform X2

  14. XM_047427010.1 → XP_047282966.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  15. XM_011545056.3 → XP_011543358.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543358.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  16. XM_047427018.1 → XP_047282974.1  nuclear mitotic apparatus protein 1 isoform X4

  17. XM_047426998.1 → XP_047282954.1  nuclear mitotic apparatus protein 1 isoform X2

  18. XM_024448556.2 → XP_024304324.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9
    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:563 → 1331
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1746 → 2016
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  19. XM_024448555.2 → XP_024304323.1  nuclear mitotic apparatus protein 1 isoform X1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  20. XM_047427021.1 → XP_047282977.1  nuclear mitotic apparatus protein 1 isoform X4

  21. XM_047427000.1 → XP_047282956.1  nuclear mitotic apparatus protein 1 isoform X2

  22. XM_047427013.1 → XP_047282969.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  23. XM_011545060.3 → XP_011543362.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543362.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  24. XM_047427022.1 → XP_047282978.1  nuclear mitotic apparatus protein 1 isoform X4

  25. XM_047427005.1 → XP_047282961.1  nuclear mitotic apparatus protein 1 isoform X2

  26. XM_047427012.1 → XP_047282968.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  27. XM_011545059.3 → XP_011543361.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543361.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  28. XM_047427009.1 → XP_047282965.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  29. XM_047426996.1 → XP_047282952.1  nuclear mitotic apparatus protein 1 isoform X1

  30. XM_047427020.1 → XP_047282976.1  nuclear mitotic apparatus protein 1 isoform X4

  31. XM_047427001.1 → XP_047282957.1  nuclear mitotic apparatus protein 1 isoform X2

  32. XM_047427011.1 → XP_047282967.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  33. XM_011545058.2 → XP_011543360.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543360.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  34. XM_017017831.2 → XP_016873320.1  nuclear mitotic apparatus protein 1 isoform X4

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    TIGR02168
    Location:1015 → 1717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:254 → 1329
    Myosin_tail_1; Myosin tail

  35. XM_047427006.1 → XP_047282962.1  nuclear mitotic apparatus protein 1 isoform X2

  36. XM_047427014.1 → XP_047282970.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  37. XM_011545062.3 → XP_011543364.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543364.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  38. XM_011545066.3 → XP_011543368.1  nuclear mitotic apparatus protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011543368.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    TIGR02168
    Location:1015 → 1717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:254 → 1329
    Myosin_tail_1; Myosin tail

  39. XM_011545065.3 → XP_011543367.1  nuclear mitotic apparatus protein 1 isoform X2

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    TIGR02168
    Location:1015 → 1717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:254 → 1329
    Myosin_tail_1; Myosin tail

  40. XM_006718564.3 → XP_006718627.1  nuclear mitotic apparatus protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006718627.1

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9
    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:563 → 1331
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1746 → 2016
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  41. XM_011545054.3 → XP_011543356.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543356.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  42. XM_047427025.1 → XP_047282981.1  nuclear mitotic apparatus protein 1 isoform X4

  43. XM_047427017.1 → XP_047282973.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  44. XM_011545064.2 → XP_011543366.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543366.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  45. XM_047427002.1 → XP_047282958.1  nuclear mitotic apparatus protein 1 isoform X2

  46. XM_047427024.1 → XP_047282980.1  nuclear mitotic apparatus protein 1 isoform X4

    Related
    ENSP00000478624.1, ENST00000620566.4

  47. XM_047427007.1 → XP_047282963.1  nuclear mitotic apparatus protein 1 isoform X2

  48. XM_047427015.1 → XP_047282971.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  49. XM_011545063.3 → XP_011543365.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543365.1

    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    cl25732
    Location:215 → 911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:1764 → 2034
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    71929780..72007446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368967.1 → XP_054224942.1  nuclear mitotic apparatus protein 1 isoform X4

  2. XM_054368943.1 → XP_054224918.1  nuclear mitotic apparatus protein 1 isoform X2

  3. XM_054368958.1 → XP_054224933.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  4. XM_054368931.1 → XP_054224906.1  nuclear mitotic apparatus protein 1 isoform X1

  5. XM_054368960.1 → XP_054224935.1  nuclear mitotic apparatus protein 1 isoform X4

  6. XM_054368937.1 → XP_054224912.1  nuclear mitotic apparatus protein 1 isoform X2

  7. XM_054368924.1 → XP_054224899.1  nuclear mitotic apparatus protein 1 isoform X1

  8. XM_054368963.1 → XP_054224938.1  nuclear mitotic apparatus protein 1 isoform X4

  9. XM_054368939.1 → XP_054224914.1  nuclear mitotic apparatus protein 1 isoform X2

  10. XM_054368950.1 → XP_054224925.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  11. XM_054368926.1 → XP_054224901.1  nuclear mitotic apparatus protein 1 isoform X1

  12. XM_054368971.1 → XP_054224946.1  nuclear mitotic apparatus protein 1 isoform X4

  13. XM_054368944.1 → XP_054224919.1  nuclear mitotic apparatus protein 1 isoform X2

  14. XM_054368952.1 → XP_054224927.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  15. XM_054368928.1 → XP_054224903.1  nuclear mitotic apparatus protein 1 isoform X1

  16. XM_054368932.1 → XP_054224907.1  nuclear mitotic apparatus protein 1 isoform X1

  17. XM_054368962.1 → XP_054224937.1  nuclear mitotic apparatus protein 1 isoform X4

  18. XM_054368949.1 → XP_054224924.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  19. XM_054368938.1 → XP_054224913.1  nuclear mitotic apparatus protein 1 isoform X2

  20. XM_054368925.1 → XP_054224900.1  nuclear mitotic apparatus protein 1 isoform X1

  21. XM_054368965.1 → XP_054224940.1  nuclear mitotic apparatus protein 1 isoform X4

  22. XM_054368940.1 → XP_054224915.1  nuclear mitotic apparatus protein 1 isoform X2

  23. XM_054368955.1 → XP_054224930.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  24. XM_054368927.1 → XP_054224902.1  nuclear mitotic apparatus protein 1 isoform X1

  25. XM_054368966.1 → XP_054224941.1  nuclear mitotic apparatus protein 1 isoform X4

  26. XM_054368945.1 → XP_054224920.1  nuclear mitotic apparatus protein 1 isoform X2

  27. XM_054368954.1 → XP_054224929.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  28. XM_054368933.1 → XP_054224908.1  nuclear mitotic apparatus protein 1 isoform X1

  29. XM_054368951.1 → XP_054224926.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  30. XM_054368964.1 → XP_054224939.1  nuclear mitotic apparatus protein 1 isoform X4

  31. XM_054368941.1 → XP_054224916.1  nuclear mitotic apparatus protein 1 isoform X2

  32. XM_054368953.1 → XP_054224928.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  33. XM_054368929.1 → XP_054224904.1  nuclear mitotic apparatus protein 1 isoform X1

  34. XM_054368968.1 → XP_054224943.1  nuclear mitotic apparatus protein 1 isoform X4

  35. XM_054368946.1 → XP_054224921.1  nuclear mitotic apparatus protein 1 isoform X2

  36. XM_054368956.1 → XP_054224931.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  37. XM_054368934.1 → XP_054224909.1  nuclear mitotic apparatus protein 1 isoform X1

  38. XM_054368961.1 → XP_054224936.1  nuclear mitotic apparatus protein 1 isoform X4

  39. XM_054368936.1 → XP_054224911.1  nuclear mitotic apparatus protein 1 isoform X2

  40. XM_054368948.1 → XP_054224923.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  41. XM_054368923.1 → XP_054224898.1  nuclear mitotic apparatus protein 1 isoform X1

  42. XM_054368970.1 → XP_054224945.1  nuclear mitotic apparatus protein 1 isoform X4

  43. XM_054368959.1 → XP_054224934.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  44. XM_054368942.1 → XP_054224917.1  nuclear mitotic apparatus protein 1 isoform X2

  45. XM_054368935.1 → XP_054224910.1  nuclear mitotic apparatus protein 1 isoform X1

  46. XM_054368957.1 → XP_054224932.1  nuclear mitotic apparatus protein 1 isoform X3

    UniProtKB/Swiss-Prot
    H0YH75, Q14980, Q14981, Q9BTE9

  47. XM_054368969.1 → XP_054224944.1  nuclear mitotic apparatus protein 1 isoform X4

  48. XM_054368947.1 → XP_054224922.1  nuclear mitotic apparatus protein 1 isoform X2

  49. XM_054368930.1 → XP_054224905.1  nuclear mitotic apparatus protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14980.2 GenPept UniProtKB/Swiss-Prot:Q14980

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous