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NPY6R neuropeptide Y receptor Y6 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 4888, updated on 16-Jan-2024

Summary

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Official Symbol
NPY6Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y6 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:7959
See related
Ensembl:ENSG00000293504 MIM:601770; AllianceGenome:HGNC:7959
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2; Y2B; NPY1RL; NPY6RP
Summary
Predicted to enable pancreatic polypeptide receptor activity and peptide YY receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 55.5), duodenum (RPKM 9.3) and 5 other tissues See more
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Genomic context

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See NPY6R in Genome Data Viewer
Location:
5q31.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (137801193..137810751)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (138327615..138337173)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137136882..137146440)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene kelch like family member 3 Neighboring gene microRNA 874 Neighboring gene MPRA-validated peak5486 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137020129-137020374 Neighboring gene Sharpr-MPRA regulatory region 14679 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137023227-137023961 Neighboring gene VISTA enhancer hs2181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23184 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:137071377-137072045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137088711-137089402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:137090093-137090784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23187 Neighboring gene heterogeneous nuclear ribonucleoprotein A0 Neighboring gene uncharacterized LOC107986368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23189 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:137199613-137199779 Neighboring gene PKD2L2 divergent transcript Neighboring gene myotilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine "Y5" receptor may be a pseudogene. Rose PM, et al. J Biol Chem, 1997 Feb 7. PMID 9013614
  2. Neuropeptide Y receptor gene y6: multiple deaths or resurrections? Starbäck P, et al. Biochem Biophys Res Commun, 2000 Oct 14. PMID 11027673
  3. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. Gregor P, et al. J Biol Chem, 1996 Nov 1. PMID 8910373
  4. Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. Matsumoto M, et al. J Biol Chem, 1996 Nov 1. PMID 8910290
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Clone Names

  • FLJ52676, FLJ53561

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables neuropeptide Y receptor activity IKR
Inferred from Key Residues
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in G protein-coupled receptor signaling pathway IKR
Inferred from Key Residues
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002713.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC106791, DC357138
    Related
    ENST00000510937.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    137801193..137810751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    138327615..138337173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_024720.1: Suppressed sequence

    Description
    NG_024720.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99463.1 GenPept UniProtKB/Swiss-Prot:Q99463

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous