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NGFR nerve growth factor receptor [ Homo sapiens (human) ]

Gene ID: 4804, updated on 5-Mar-2024

Summary

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Official Symbol
NGFRprovided by HGNC
Official Full Name
nerve growth factor receptorprovided by HGNC
Primary source
HGNC:HGNC:7809
See related
Ensembl:ENSG00000064300 MIM:162010; AllianceGenome:HGNC:7809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
Summary
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 11.7), adrenal (RPKM 11.6) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
17q21.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49495293..49515008)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50358300..50378028)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47572655..47592370)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12362 Neighboring gene eukaryotic translation initiation factor 4E pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47563643-47564348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47585797-47586448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47587100-47587750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47587751-47588401 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:47588857-47589824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47590890-47591665 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47591666-47592440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47592441-47593216 Neighboring gene NGFR antisense RNA 1 Neighboring gene microRNA 6165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47654119-47654649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47659009-47659562 Neighboring gene neurexophilin 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47683760-47683957 Neighboring gene uncharacterized LOC107984999 Neighboring gene NANOG hESC enhancer GRCh37_chr17:47695165-47695679 Neighboring gene speckle type BTB/POZ protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Nerve Growth Factor Receptor (NGFR/p75(NTR)): A Major Player in Alzheimer's Disease. Bruno F, et al. Int J Mol Sci, 2023 Feb 6. PMID 36834612, Free PMC Article
  2. Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid-β deposition in the brain. He CY, et al. CNS Neurosci Ther, 2022 Dec. PMID 36074475, Free PMC Article
  3. Isolation of an "Early" Transit Amplifying Keratinocyte Population in Human Epidermis: A Role for the Low Affinity Neurotrophin Receptor CD271. Lotti R, et al. Stem Cells, 2022 Dec 31. PMID 36037263, Free PMC Article
  4. Age-related decrease in responsiveness of CD271-positive skin stem cells to growth factors. Akamatsu H, et al. Exp Dermatol, 2022 Aug. PMID 35524485
  5. Upregulation of CD271 transcriptome in breast cancer promotes cell survival via NFÎşB pathway. Bashir N, et al. Mol Biol Rep, 2022 Jan. PMID 34755264

See all (376) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.
    Title: Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.
  2. CD271 promotes proliferation and migration in bladder cancer.
    Title: CD271 promotes proliferation and migration in bladder cancer.
  3. Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease.
    Title: Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease.
  4. The Nerve Growth Factor Receptor (NGFR/p75[NTR]): A Major Player in Alzheimer's Disease.
    Title: The Nerve Growth Factor Receptor (NGFR/p75(NTR)): A Major Player in Alzheimer's Disease.
  5. Isolation of an "Early" Transit Amplifying Keratinocyte Population in Human Epidermis: A Role for the Low Affinity Neurotrophin Receptor CD271.
    Title: Isolation of an "Early" Transit Amplifying Keratinocyte Population in Human Epidermis: A Role for the Low Affinity Neurotrophin Receptor CD271.
  6. Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.
    Title: Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.
  7. Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid-beta deposition in the brain.
    Title: Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid-β deposition in the brain.
  8. RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.
    Title: RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.
  9. Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer.
    Title: Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer.
  10. Age-related decrease in responsiveness of CD271-positive skin stem cells to growth factors.
    Title: Age-related decrease in responsiveness of CD271-positive skin stem cells to growth factors.
Submit: New GeneRIF Correction See all GeneRIFs (264)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of nerve growth factor receptor is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding TAS
Traceable Author Statement
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables death receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables death receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nerve growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nerve growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neurotrophin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in detection of temperature stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in dorsal aorta development IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of miRNA transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in endosome TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 16
Names
NGF receptor
TNFR superfamily, member 16
low affinity neurotrophin receptor p75NTR
low-affinity nerve growth factor receptor
low-affinity nerve growth factor receptor p75NGFR
low-affinity nerve growth factor receptor p75NGR
p75 ICD

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002507.4 → NP_002498.1  tumor necrosis factor receptor superfamily member 16 precursor

    See identical proteins and their annotated locations for NP_002498.1

    Status: REVIEWED

    Source sequence(s)
    BQ639556, CK299927, DA115173, M14764
    Consensus CDS
    CCDS11549.1
    UniProtKB/Swiss-Prot
    B2R961, B4E096, P08138
    Related
    ENSP00000172229.3, ENST00000172229.8
    Conserved Domains (2) summary
    cd08311
    Location:340 → 418
    Death_p75NR; Death domain of p75 Neurotrophin Receptor
    cd13416
    Location:30 → 188
    TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    49495293..49515008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    50358300..50378028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08138.1 GenPept UniProtKB/Swiss-Prot:P08138

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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