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NFKBIB NFKB inhibitor beta [ Homo sapiens (human) ]

Gene ID: 4793, updated on 3-Apr-2024

Summary

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Official Symbol
NFKBIBprovided by HGNC
Official Full Name
NFKB inhibitor betaprovided by HGNC
Primary source
HGNC:HGNC:7798
See related
Ensembl:ENSG00000104825 MIM:604495; AllianceGenome:HGNC:7798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKBB; TRIP9
Summary
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Expression
Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38899666..38908889)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41703721..41712860)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39390306..39399529)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360061-39360631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360661-39361267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39361268-39361873 Neighboring gene Ras and Rab interactor like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14603 Neighboring gene sirtuin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39384205-39384706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39402426-39403052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39403053-39403677 Neighboring gene coiled-coil glutamate rich protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39408779-39409649 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14604

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling. Phoon YP, et al. Int J Cancer, 2016 Jan 1. PMID 26227166
  2. A new regulatory mechanism of NF-kappaB activation by I-kappaBbeta in cancer cells. Kim JM, et al. J Mol Biol, 2008 Dec 26. PMID 18950638
  3. Regulation of IkappaBbeta expression in testis. Budde LM, et al. Mol Biol Cell, 2002 Dec. PMID 12475944, Free PMC Article
  4. Expression of nuclear factor kappa B components in human endometrium. Page M, et al. J Reprod Immunol, 2002 Mar. PMID 11839392
  5. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. Okamoto T, et al. Cytogenet Cell Genet, 1998. PMID 9763672

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The NF-kappaB regulator IkappaBbeta exhibits different molecular interactivity and phosphorylation status from IkappaBalpha in an IKK2-catalysed reaction.
    Title: The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.
  2. The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib.
    Title: Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IκB and Downregulation of Survivin.
  3. data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB.
    Title: Upregulation of miRNA-4776 in Influenza Virus Infected Bronchial Epithelial Cells Is Associated with Downregulation of NFKBIB and Increased Viral Survival.
  4. our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway.
    Title: IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling.
  5. NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing.
    Title: Genetic polymorphisms and risk of recurrent wheezing in pediatric age.
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  7. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
    Title: Integrative predictive model of coronary artery calcification in atherosclerosis.
  8. NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles.
    Title: Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer.
  9. increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization.
    Title: A new regulatory mechanism of NF-kappaB activation by I-kappaBbeta in cancer cells.
  10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
Tat tat The gene expression of NFKBIB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat I kappa B potently inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat induces the phosphorylation and degradation of IkappaB through a p56lck dependent mechanism, leading to the activation of NF-kappa B PubMed
Vpr vpr HIV-1 Vpr induces phosphorylation of IkappaB-beta at serine positions 177 and 181 PubMed
vpr Overexpression of NFKBIB is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor beta
Names
I-kappa-B-beta
NF-kappa-BIB
TR-interacting protein 9
TRIP-9
ikB-B
ikB-beta
ikappaBbeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
thyroid receptor-interacting protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029624.1 RefSeqGene

    Range
    5270..14190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243116.2 → NP_001230045.1  NF-kappa-B inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001230045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AC011455, AI684894, BC015528, BI520169
    Consensus CDS
    CCDS74362.1
    UniProtKB/TrEMBL
    G5E9C2, I3L4X3
    Related
    ENSP00000375929.4, ENST00000392079.7
    Conserved Domains (3) summary
    cd00204
    Location:2 → 175
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:125 → 212
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:120 → 151
    ANK; ANK repeat [structural motif]

  2. NM_001369699.1 → NP_001356628.1  NF-kappa-B inhibitor beta isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB209784, AC011455
    Consensus CDS
    CCDS92612.1
    UniProtKB/TrEMBL
    Q59EM7
    Related
    ENSP00000459728.1, ENST00000572515.5
    Conserved Domains (3) summary
    PHA03095
    Location:203 → 298
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:57 → 148
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:206 → 237
    ANK; ANK repeat [structural motif]

  3. NM_001369700.1 → NP_001356629.1  NF-kappa-B inhibitor beta isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011455
    Conserved Domains (3) summary
    PHA03095
    Location:111 → 206
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:114 → 145
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:52 → 142
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_002503.5 → NP_002494.2  NF-kappa-B inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_002494.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI684894, BC015528, DA633677
    Consensus CDS
    CCDS12524.1
    UniProtKB/Swiss-Prot
    A8K3F4, Q15653, Q96BJ7
    UniProtKB/TrEMBL
    Q59EM7
    Related
    ENSP00000312988.5, ENST00000313582.6
    Conserved Domains (4) summary
    COG0666
    Location:240 → 299
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:88 → 261
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:206 → 237
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:52 → 118
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_040515.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at the second exon, and is alternatively spliced at the 3' end compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF (with a strong Kozak signal) that is predicted to interfere with the translation of the downstream longer ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA044256, AB209784, AK057862, BX111397, DA633677
    Related
    ENST00000509705.3

  2. NR_161470.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011455

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38899666..38908889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723227.4 → XP_006723290.4  NF-kappa-B inhibitor beta isoform X2

    UniProtKB/TrEMBL
    G5E9C2

  2. XM_006723226.3 → XP_006723289.2  NF-kappa-B inhibitor beta isoform X1

    UniProtKB/TrEMBL
    Q96LS1
    Conserved Domains (3) summary
    cd00204
    Location:56 → 229
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:179 → 266
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:174 → 205
    ANK; ANK repeat [structural motif]

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p14 PATCHES

    Range
    309338..318561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331970.1 → XP_054187945.1  NF-kappa-B inhibitor beta isoform X2

    UniProtKB/TrEMBL
    G5E9C2

  2. XM_054331969.1 → XP_054187944.1  NF-kappa-B inhibitor beta isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41703721..41712860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321077.1 → XP_054177052.1  NF-kappa-B inhibitor beta isoform X2

    UniProtKB/TrEMBL
    G5E9C2

  2. XM_054321076.1 → XP_054177051.1  NF-kappa-B inhibitor beta isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001716.1: Suppressed sequence

    Description
    NM_001001716.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15653.2 GenPept UniProtKB/Swiss-Prot:Q15653

Gene LinkOut

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